RETRACTED ARTICLE:
 In vitro
 and
 in vivo
 biocompatibility study of polyacrylate TiO
 2
 @Ag coated nanoparticles for the radiation dose enhancement

Rehman, Ateeque Ur; Hassan, Muhammad; Bano, Sadia; Farooq, Khizir; Raza, Aun; Anjum, Muhammad Naeem

doi:10.1080/21691401.2021.1889574

Cited by 6 publications

(3 citation statements)

References 39 publications

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“…However, hybrid combinations of silver NPs with other types of NPs can strengthen the sensitizing effect 171–175 . In order to combine the different properties of separate NPs together, the easiest way is to coat them both in a suitable shell, such as silica 176 .…”

Section: High‐z Np‐based Radiosensitizersmentioning

confidence: 99%

“…170 However, hybrid combinations of silver NPs with other types of NPs can strengthen the sensitizing effect. [171][172][173][174][175] In order to combine the different properties of separate NPs together, the easiest way is to coat them both in a suitable shell, such as silica. 176 On the other hand, to design effective NPs for cancer radiation therapy, selective targeting of tumor cells using various strategies is important.…”

Section: Silver Npsmentioning

confidence: 99%

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Application of nano‐radiosensitizers in combination cancer therapy

Varzandeh

Sabouri

Mansouri

et al. 2023

Bioengineering & Transla Med

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Radiosensitizers are compounds or nanostructures, which can improve the efficiency of ionizing radiation to kill cells. Radiosensitization increases the susceptibility of cancer cells to radiation‐induced killing, while simultaneously reducing the potentially damaging effect on the cellular structure and function of the surrounding healthy tissues. Therefore, radiosensitizers are therapeutic agents used to boost the effectiveness of radiation treatment. The complexity and heterogeneity of cancer, and the multifactorial nature of its pathophysiology has led to many approaches to treatment. The effectiveness of each approach has been proven to some extent, but no definitive treatment to eradicate cancer has been discovered. The current review discusses a broad range of nano‐radiosensitizers, summarizing possible combinations of radiosensitizing NPs with several other types of cancer therapy options, focusing on the benefits and drawbacks, challenges, and future prospects.

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Section: High‐z Np‐based Radiosensitizersmentioning

confidence: 99%

Section: Silver Npsmentioning

confidence: 99%

Application of nano‐radiosensitizers in combination cancer therapy

Varzandeh

Sabouri

Mansouri

et al. 2023

Bioengineering & Transla Med

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“…Production of ROS is likely to be dependent on many variables and characteristics of the metal NP, such as size, shape and surface chemistry. The surface properties of NPs such as their interfacial layers, coatings, functionalization, and/or capping agents can play a significant role in ROS generation [ 109 – 111 ]. Haume et al [ 112 ] reported that the OH radical yield showed a six-fold decrease for PEG-coated gold nanoparticles compared to naked nanoparticle.…”

Section: Chemical and Physico-chemical Responses Of Coated Npsmentioning

confidence: 99%

The effect of nanoparticle coating on biological, chemical and biophysical parameters influencing radiosensitization in nanoparticle-aided radiation therapy

Mansouri,

Mesbahi,

Hamishehkar

et al. 2023

BMC Chemistry

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Nanoparticle-based composites have the potential to meet requirements for radiosensitization in both therapeutic and diagnostic applications. The radiosensitizing properties of nanoparticles could be reliant on the nature of their coating layer. Any gains in reduced toxicity and aggregation or improved delivery to tumor cells for coated nanoparticles must be weighed against the loss of dose enhancement. The radiosensitization potential of coated NPs is confirmed by numerous studies but in most of them, the coating layer is mostly applied to reduce toxicity of the NPs and for stability and biocompatibility aims. While the direct effects of the coating layer in radiosensitization—were ignored and not considered. This review provides an overview of double-edged impact of nanoparticle coating on the radiosensitization potential of nanostructures and discusses the challenges in choosing appropriate coating material in the aim of achieving improved radioenhancement. Coating layer could affect the radiosensitization processes and thereby the biological outcomes of nanoparticle-based radiation therapy. The physicochemical properties of the coating layer can be altered by the type of the coating material and its thickness. Under low-energy photon irradiation, the coating layer could act as a shield for nanoparticles capable of absorb produced low-energy electrons which are important levers for local and nanoscopic dose enhancement. Also, it seems that the coating layer could mostly affect the chemical process of ROS production rather than the physicochemical process. Based on the reviewed literature, for the irradiated coated nanoparticles, the cell survival and viability of cancer cells are decreased more than normal cells. Also, cell cycle arrest, inhibition of cell proliferation, DNA damage, cell death and apoptosis were shown to be affected by coated metallic nanoparticles under irradiation.

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Radiosensitizers in Radiation-Induced Cancer Therapy

Rashidzadeh

Mozafari

Rahimi

et al. 2022

Harnessing Materials for X-Ray Based Cancer Therapy and Imaging

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RETRACTED ARTICLE: In vitro and in vivo biocompatibility study of polyacrylate TiO ₂ @Ag coated nanoparticles for the radiation dose enhancement

Cited by 6 publications

References 39 publications

Application of nano‐radiosensitizers in combination cancer therapy

Application of nano‐radiosensitizers in combination cancer therapy

The effect of nanoparticle coating on biological, chemical and biophysical parameters influencing radiosensitization in nanoparticle-aided radiation therapy

Radiosensitizers in Radiation-Induced Cancer Therapy

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RETRACTED ARTICLE: In vitro and in vivo biocompatibility study of polyacrylate TiO 2 @Ag coated nanoparticles for the radiation dose enhancement

Cited by 6 publications

References 39 publications

Application of nano‐radiosensitizers in combination cancer therapy

Application of nano‐radiosensitizers in combination cancer therapy

The effect of nanoparticle coating on biological, chemical and biophysical parameters influencing radiosensitization in nanoparticle-aided radiation therapy

Radiosensitizers in Radiation-Induced Cancer Therapy

Contact Info

Product

Resources

About

RETRACTED ARTICLE: In vitro and in vivo biocompatibility study of polyacrylate TiO ₂ @Ag coated nanoparticles for the radiation dose enhancement