RETRACTED ARTICLE: Isoginkgetin attenuates endoplasmic reticulum stress-induced autophagy of brain after ischemic reperfusion injury

Li, Yueyong; Meng, Lingzhang; Li, Baosheng; Huang, Deyou; Huang, Xiaohua; Lin, Cheng; Li, Dong; Qiu, Shaocai; Wu, Yingning; Wei, Zhongheng; Li, Xuebin

doi:10.1080/21655979.2021.1997564

Cited by 9 publications

(6 citation statements)

References 34 publications

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“…Of note, no effective therapy is available to treat obesity-associated MC and its complications. Isoginkgetin, a biflavone from Ginkgo Biloba , was identified as an inhibitor of RNA splicing [ 38 ] and was reported to possess multiple protective effects including anti-inflammation [ 21 , 39 , 40 ], anti-oxidative stress [ 20 ] and anti-tumorigenic activities [ 41 , 42 ]. Our data demonstrated for the first time that IGK ameliorated diastolic dysfunction, cardiac hypertrophy and cardiac fibrosis in diet-induced obese mice.…”

Section: Discussionmentioning

confidence: 99%

“…This 3′,8″-dimerization enhanced the antioxidant capacity of IGK compared with acacetin in vitro [ 20 ]. In a rodent model of cerebral ischemia/reperfusion injury, IGK treatment significantly counteracted cerebral infarction and neuron apoptosis [ 21 ]. However, the effects and molecular mechanism of IGK in heart disease remain elusive.…”

Section: Introductionmentioning

confidence: 99%

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Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling

Huang

Tang

et al. 2022

Redox Biology

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling

Huang

Tang

et al. 2022

Redox Biology

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“…The SUSTech-SYSU dataset is the third dataset [35]. This dataset was created for the aim of detecting exudates and gradation.…”

Section: ░ 3 Materials and Methodsmentioning

confidence: 99%

An Integrated Fundus Image Segmentation Algorithm for Multiple Eye Ailments

Datta

Das

Kumar

2021

IJEER

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The detection of eye illnesses requires a thorough inspection of all of the eye's structures. Most significantly, the presence of blood vessels, an optical disc, and any other unwelcome objects, if any are discovered, is critical in determining the type of eye disease present. Specifically, the goal of this research is to establish a thorough segmentation framework that will aid in the detection of anatomical anomalies in the eye. A novel segmentation technique for analyzing blood vessels, optical disc health, and the presence of exudates has been added into the software. - It was decided to add the detection of aberrant objects such as exudates into the algorithm in order to develop a generic segmentation method. In order to verify the accuracy of the segmentation at each stage, random sampling is employed at each stage. The segmentation is then validated using the intersection over union metric. The accuracy of the integrated segmentation method as a whole is 91.66 percent.

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“…As summarized by Adnan et al [ 75 ], ginkgetin shows potent neuroprotective effects against oxidative stress-induced cell death, inhibits cerebral microbleeds, reduces neurological deficits, and stops apoptosis of neurons. Isoginkgetin also shows promising results in in vivo studies in rats as a novel therapeutic agent in the treatment of ischemic stroke injury [ 112 ]. As summarized by Varshney et al [ 113 ], amentoflavone also has therapeutic and medicinal potential in the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease, as well as in the treatment of depression and in the prevention of aging.…”

Section: Biological Activity Of Ginkgobiflavonoidsmentioning

confidence: 99%

Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)

Šamec

Karalija

Dahija

et al. 2022

Plants

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Ginkgo (Ginkgo biloba L.) is one of the most distinctive plants, characterized by excellent resistance to various environmental conditions. It is used as an ornamental plant and is recognized as a medicinal plant in both traditional and Western medicine. Its bioactive potential is associated with the presence of flavonoids and terpene trilactones, but many other compounds may also have synergistic effects. Flavonoid dimers—biflavonoids—are important constituents of ginkgophytopharmaceuticals. Currently, the presence of 13 biflavonoids has been reported in ginkgo, of which amentoflavone, bilobetin, sciadopitysin, ginkgetin and isoginkgetin are the most common. Their role in plants remains unknown, but their bioactivity and potential role in the management of human health are better investigated. In this review, we have provided an overview of the chemistry, diversity and biological factors that influence the presence of biflavonoids in ginkgo, as well as their bioactive and health-related properties. We have focused on their antioxidant, anticancer, antiviral, antibacterial, antifungal and anti-inflammatory activities as well as their potential role in the treatment of cardiovascular, metabolic and neurodegenerative diseases. We also highlighted their potential toxicity and pointed out further research directions.

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RETRACTED ARTICLE: Isoginkgetin attenuates endoplasmic reticulum stress-induced autophagy of brain after ischemic reperfusion injury

Cited by 9 publications

References 34 publications

Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling

Isoginkgetin, a bioactive constituent from Ginkgo Biloba, protects against obesity-induced cardiomyopathy via enhancing Nrf2/ARE signaling

An Integrated Fundus Image Segmentation Algorithm for Multiple Eye Ailments

Biflavonoids: Important Contributions to the Health Benefits of Ginkgo (Ginkgo biloba L.)

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