RETRACTED ARTICLE: Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial

Darwish, Atef M.; Fouly, Howieda; Saied, W. H.; Farah, E.

doi:10.1080/14767058.2018.1429396

Cited by 8 publications

(13 citation statements)

References 16 publications

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“…Non-iron interventions had the lowest SUCRA value (22%; appendix p 37). The detailed ranking measures, including SUCRA and mean rank, are presented in the appendix (pp [34][35][36][37][38].…”

Section: Resultsmentioning

confidence: 99%

Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis

Rogozińska

Daru

Nicolaides

et al. 2021

The Lancet Haematology

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Section: Resultsmentioning

confidence: 99%

Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis

Rogozińska

Daru

Nicolaides

et al. 2021

The Lancet Haematology

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“…The basic characteristics of the randomized controlled trials included in the systematic review are presented in Table 3 . The randomized controlled trials included in the systematic review were conducted in populations of anemic women [ 22 , 23 ], or mixed populations of anemic and non-anemic women [ 24 , 25 , 26 , 27 , 28 ], from Asian countries: India [ 22 , 27 ], Vietnam [ 25 ], Indonesia [ 26 ], Cambodia [ 28 ], or African countries: Tanzania [ 24 ] and Egypt [ 23 ]. The interventions described within the studies included fortified products [ 24 , 25 , 28 ], regular products [ 26 ], or dietary counselling [ 22 , 23 , 27 , 28 ], while effectiveness was compared with the effectiveness of a placebo product [ 24 , 25 ], various supplementations [ 23 , 25 ], or a control group without any intervention [ 22 , 26 , 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the participants of the randomized controlled trials included in the systematic review is presented in Table 4 . The randomized controlled trials included in the systematic review were conducted in medium-size populations of less than 100 participants [ 23 , 27 ], or large populations of more than 100 participants [ 22 , 24 , 25 , 26 , 28 ]. Within the inclusion and exclusion criteria there were indicated characteristics such as specific hemoglobin blood level [ 22 , 23 , 24 , 25 ], specific age [ 23 , 25 , 26 , 27 , 28 ], and specific weeks of gestation [ 22 , 23 , 24 , 26 , 27 , 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…The description of the intervention applied within the randomized controlled trials included in the systematic review is presented in Table 5 . The applied dietary interventions were based on providing increased amount of iron [ 23 , 25 ], providing increased amount of multiple nutrients [ 22 , 24 , 26 , 28 ], or general counselling only [ 27 ]. The study duration was diversified from few weeks [ 23 , 24 ], through few months [ 22 , 25 , 27 ], to half a year or longer [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

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Effectiveness of Dietary Interventions in Prevention and Treatment of Iron-Deficiency Anemia in Pregnant Women: A Systematic Review of Randomized Controlled Trials

et al. 2022

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Pregnant women are among the population groups most vulnerable to the development of anemia, as the overall iron requirement during pregnancy is significantly higher than in non-pregnant women. The aim of the systematic review was to assess the effectiveness of dietary interventions in the prevention and treatment of iron-deficiency anemia in pregnant women based on randomized-controlled trials. The systematic review was based on the PRISMA guidelines and is registered in the PROSPERO database (CRD42021261235). The search was conducted within PubMed and Web of Science databases for the period until June 2021. The included randomized controlled trials presented effectiveness of dietary interventions in prevention and treatment of iron-deficiency anemia in pregnant women. From the total number of 7825 screened records, the final number of seven studies were included in the systematic review. The procedure of screening, inclusion, reporting, and assessment of the risk of bias while using the revised Cochrane risk of bias tool for randomized trials was conducted by two independent researchers. The studies included in the systematic review were conducted in populations of anemic pregnant women, or mixed populations of anemic and non-anemic pregnant women. The interventions described within the studies were associated with including fortified products, regular products, or dietary counselling. They were based on providing an increased amount of iron, providing an increased amount of multiple nutrients, or general counselling only, while effectiveness was compared with effectiveness of the placebo, supplementation, or control group. The study duration was diversified from a few weeks to half a year or longer. The major biochemical measure assessed within the included studies was hemoglobin. All applied dietary interventions, based on providing increased amount of iron, providing increased amount of multiple nutrients, or general counselling only, were effective. The majority of included studies were assessed as ones of a medium risk of bias. For some studies a high risk of bias was indicated, which resulted from a risk of bias arising from the randomization process, due to deviations from the intended interventions, and in selection of the reported result. Considering this fact, more randomized controlled trials should be planned and conducted in a rigorous manner to confirm the formulated observations of effectiveness of the studied interventions based on providing an increased amount of iron, providing an increased amount of multiple nutrients, or general counselling only.

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“…The control group was mostly treated orally with standard preparations of iron sulfate (corresponding to 156 mg of elementary iron). The therapy was conducted for 30–90 days or longer (from the end of first trimester to delivery) [ 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 ].…”

Section: Lactoferrin In Prophylaxis and Treatment Of Anemia In Pregnancymentioning

confidence: 99%

Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review

Artym

Zimecki

Kruzel³

2021

Biomedicines

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Pregnancy is a physiological state that demands higher level of nutrients, including vitamins and minerals, for the growth and maintenance of the fetus. Iron deficiency is a part of most common diet deficiencies in pregnancy and has high clinical significance leading to the development of syderopenic anemia and its consequences for mother and child, such as higher risk of perinatal death, susceptibility to infection, intra-uteral growth inhibition, prematurity and low birth weight. Hence, iron supplementation is recommended for pregnant women; however dietary intake of iron from most commercially available formulas is often insufficient due to iron-poor bioavailability, or have undesired side-effects in the gastrointestinal tract, resulting in a discouraging and distrustful attitude to such treatment. The results of numerous studies indicate that diet supplementation with lactoferrin (LTF), an iron-binding protein, may be advantageous in prophylaxis and treatment of iron deficiency anemia. LTF, administered orally, normalizes iron homeostasis, not only by facilitating iron absorption, but also by inhibiting inflammatory processes responsible for anemia of chronic diseases, characterized by a functional iron deficit for physiological processes. LTF also protects against infections and inflammatory complications, caused by diagnostic surgical interventions in pregnant women. Beneficial, multidirectional actions of LTF during pregnancy encompass, in addition, inhibition of oxidative stress, normalization of intestine and genital tract microbiota and carbohydrate-lipid metabolism, protection of intestine barrier function, promotion of wound healing, as well as hypotensive, analgesic and antistress actions. Bovine lactoferrin (BLTF) is readily available on the nutritional market and generally recognized as safe (GRAS) for use in human diet.

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RETRACTED ARTICLE: Lactoferrin plus health education versus total dose infusion (TDI) of low-molecular weight (LMW) iron dextran for treating iron deficiency anemia (IDA) in pregnancy: a randomized controlled trial

Cited by 8 publications

References 16 publications

Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis

Iron preparations for women of reproductive age with iron deficiency anaemia in pregnancy (FRIDA): a systematic review and network meta-analysis

Effectiveness of Dietary Interventions in Prevention and Treatment of Iron-Deficiency Anemia in Pregnant Women: A Systematic Review of Randomized Controlled Trials

Lactoferrin for Prevention and Treatment of Anemia and Inflammation in Pregnant Women: A Comprehensive Review

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