RETRACTED ARTICLE: Magnolol prevented brain injury through the modulation of Nrf2-dependent oxidative stress and apoptosis in PLP-induced mouse model of multiple sclerosis

Bibi, Tehmina; Khan, Adnan; Khan, Ashraf Ullah; Shal, Bushra; Ali, Hussain; Seo, Eun Kyoung; Khan, Salman

doi:10.1007/s00210-022-02230-6

Cited by 16 publications

(11 citation statements)

References 62 publications

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“…The content of MDA (an important biomarker of oxidant status) directly reflected the level and degree of LPO and the body lipid damage caused by active free radical attack. Previous studies showed that the addition of Chinese herbal extracts such as anise extract, magnolol, and yucca extract to the diet improved the antioxidant status of pigeons ( Sun et al, 2019 ; Faried and El-Mehi, 2020 ; Bibi et al, 2022 ). In this study, the effect of AEF on antioxidant status under stress of breeding pigeons was explored.…”

Section: Discussionmentioning

confidence: 99%

Effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extractive on antioxidant capacity, production performance, and immune mechanism of breeding pigeons under stress

Zhang¹,

Zhou²,

Liang³

et al. 2023

Poultry Science

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Section: Discussionmentioning

confidence: 99%

Effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extractive on antioxidant capacity, production performance, and immune mechanism of breeding pigeons under stress

Zhang¹,

Zhou²,

Liang³

et al. 2023

Poultry Science

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“…In respect of structures, template fits and anti-oxidative properties, fingolimod, xanomeline and ambroxol are comparable compounds. The neuroprotective properties of magnol extend to reversing EAE associated histopathology [40]. 3-nitrotyrosine, a stress marker inducing motor neurone death in vitro [29] [58] and anti-apoptotic cannabidiol [41] demonstrate the different fits of neurotoxic and neuroprotective compounds.…”

Section: Discussionmentioning

confidence: 99%

“…Compounds providing protection against experimentally induced diabetes and β-cell apoptosis: loganin [1], taurine [2], silibinin [3], 17β-estradiol [6], vitamin D3 [7], mdivi-1 [12], metformin [12], gliclazide [35], nicotinamide [36], telmisartan [37]. Compounds providing protection against apoptosis in animal models of Parkinson's and MS respectively: ursolic acid [26], astilbin [26], β-lapachone [26], papaverine [26], embelin [26], dexrazoxane [26], schisandrin A [26], 20-hydroxyecdysone [38], NE52-QQ57 [39]; magnol [40], cannabidiol [41], monomethylfumarate [42], glucosylceramide [43].…”

Section: Compound Structuresmentioning

confidence: 99%

Relative Molecular Similarity in Compound Structures Modulating Neurodegenerative Apoptosis

Williams¹

2023

JBM

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Neurodegeneration is attributable to metabolic disturbances in the various cell types responsible for this condition, in respect of glucose utilisation and dysfunctional mitochondrial oxidative mechanisms. The properties of neurotoxins and antagonists that limit their action are well documented in disease models, whereas effective therapy is very limited. Cell apoptosis, a general marker of neurodegeneration, is also of therapeutic interest in the treatment of cancer. cGMP nucleotide influences apoptosis and has a role in maintaining equilibrium within cell redox parameters. The chemical structure of cGMP provides a comparative template for demonstrating relative molecular similarity within the structures of natural and synthetic compounds influencing tumour cell apoptosis. The present study uses computational software to investigate molecular similarity within the structures of cGMP and compounds that modulate cell apoptosis in experimental models of diabetic peripheral neuropathy (DPN), Parkinson's and multiple sclerosis. Differential molecular similarity demonstrated in neurotoxin and antagonist structures implicate metabolite impairment of cGMP signaling function as a common mechanism in the initial phases of these neurodegenerative conditions.

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“…MAG treatment significantly inhibited oxidative stress by downregulating the activities of MDA, NO and MPO, and increased the levels of antioxidants, such as GSH, GST, cat and SOD. In addition, MAG significantly enhanced the antioxidant defense system by increasing the expression level of Nrf2 while decreasing the expression of iNOS and cleaved-caspase-3 in the brain to protect myelin integrity [ 179 ].…”

Section: Natural Compounds Against Oxidative Stress In Animal Models ...mentioning

confidence: 99%

Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis

Zha

Liu

et al. 2022

Antioxidants

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Multiple sclerosis (MS) is an autoimmune-mediated degenerative disease of the central nervous system (CNS) characterized by immune cell infiltration, demyelination and axonal injury. Oxidative stress-induced inflammatory response, especially the destructive effect of immune cell-derived free radicals on neurons and oligodendrocytes, is crucial in the onset and progression of MS. Therefore, targeting oxidative stress-related processes may be a promising preventive and therapeutic strategy for MS. Animal models, especially rodent models, can be used to explore the in vivo molecular mechanisms of MS considering their similarity to the pathological processes and clinical signs of MS in humans and the significant oxidative damage observed within their CNS. Consequently, these models have been used widely in pre-clinical studies of oxidative stress in MS. To date, many natural products have been shown to exert antioxidant effects to attenuate the CNS damage in animal models of MS. This review summarized several common rodent models of MS and their association with oxidative stress. In addition, this review provides a comprehensive and concise overview of previously reported natural antioxidant products in inhibiting the progression of MS.

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RETRACTED ARTICLE: Magnolol prevented brain injury through the modulation of Nrf2-dependent oxidative stress and apoptosis in PLP-induced mouse model of multiple sclerosis

Cited by 16 publications

References 62 publications

Effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extractive on antioxidant capacity, production performance, and immune mechanism of breeding pigeons under stress

Effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extractive on antioxidant capacity, production performance, and immune mechanism of breeding pigeons under stress

Relative Molecular Similarity in Compound Structures Modulating Neurodegenerative Apoptosis

Potential Utility of Natural Products against Oxidative Stress in Animal Models of Multiple Sclerosis

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