RETRACTED: Baicalin protects human retinal pigment epithelial cell lines against high glucose-induced cell injury by up-regulation of microRNA-145

Dai, Chunhua; Jiang, Shanhao; Chu, Cuiying; Meng, Xia; Song, Xiu‐Fen; Zhao, Bojun

doi:10.1016/j.yexmp.2019.01.002

Cited by 28 publications

(20 citation statements)

References 34 publications

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“…It was once reported that TNF‐α treatment declined the expression of miR‐145 (Guo et al, ). However, another investigation specified that BAI played a protective role in high‐glucose‐evoked human retinal pigment epithelial cells through elevating miR‐145 expression (Dai et al, ). Therefore, we speculated that miR‐145 is involved in the process of BAI protecting TNF‐α‐triggered inflammatory injuries in HAECs.…”

Section: Discussionmentioning

confidence: 99%

“…An investigation conducted in atherosclerosis revealed that BAI inhibited the proliferation and migration of oxidized low‐density lipoprotein treated vascular smooth muscle cells by elevating the expression of miR‐126‐5p (Chen et al, ). Additionally, Dai et al figured out that BAI exerted its protective roles against high glucose‐evoked injuries through elevating miR‐145 expression in human pigment epithelial cells (Dai et al, ). Moreover, Shi et al specified that miR‐145‐5p overexpression rescued lncRNA TUG1 overexpression‐triggered promotion effects on proliferation and migration in vascular smooth muscle cell of hypertension (Shi, Tian, Sun, Cao, & Meng, ).…”

Section: Discussionmentioning

confidence: 99%

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Retracted: Baicalin relieves TNF‐α‐evoked injury in human aortic endothelial cells by up‐regulation of miR‐145

Liu

et al. 2019

Phytotherapy Research

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Hypertension is recognized to be associated with low‐grade inflammation. Baicalin (BAI) is reported to possess various pharmacological including anti‐inflammatory activities. This research explored the molecular mechanism by which BAI functions in human aortic endothelial cells (HAECs). HAECs were pretreated with BAI. Cell viability, apoptosis, and expressions of crucial proteins were respectively evaluated using cell counting kit‐8 assay, flow cytometry, and western blot. Productions of cytokines were respectively assessed employing quantitative real‐time polymerase chain reaction and enzyme‐linked immunosorbent assay. Cell transfection was utilized to alter miR‐145 expression. The expressions of proteins participated in JNK and p38MAPK pathways were analyzed utilizing western blot. TNF‐α inducement successfully evoked inflammatory injury in HAECs, exhibiting as prominently suppressed viability, while facilitated apoptosis and productions of cytokines. However, BAI pretreatment significantly ameliorated TNF‐α‐triggered inflammatory injuries. Besides, miR‐145 expression was markedly inhibited by TNF‐α inducement, while notably elevated by BAI pretreatment. Although miR‐145 overexpression had no significant influence on apoptosis, miR‐145 silence observably reversed BAI pretreatment‐evoked protective influences on TNF‐α‐induced HAECs, as well as the inhibited impacts on the levels of key proteins involved in JNK and p38MAPK pathways. This investigation illustrated that BAI relieved TNF‐α‐triggered injuries through upregulating miR‐145 via suppressing JNK and p38MAPK pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Retracted: Baicalin relieves TNF‐α‐evoked injury in human aortic endothelial cells by up‐regulation of miR‐145

Liu

et al. 2019

Phytotherapy Research

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“…Interestingly, the entire dose-response curves of berberine was shown to be shifted down in the presence of baicalin (100 µmol/L), and baicalin antagonised the effect of berberine on glucose uptake in 3T3-L1 adipocytes. Since the antioxidant flavonoid baicalein is known to improve a range of abnormalities associated with diabetes [80][81][82][83][84][85], its coadministration with berberine appear to have a favourable outcome in the specified dose range.…”

Section: From Drug Combination To Structural Linkage With Other Bioacmentioning

confidence: 99%

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

Habtemariam

2020

Biomedicines

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Berberine is a quaternary isoquinoline alkaloid that has been isolated from numerous plants which are still in use today as medicine and herbal supplements. The great deal of enthusiasm for intense research on berberine to date is based on its diverse pharmacological effects via action on multiple biological targets. Its poor bioavailability resulting from low intestinal absorption coupled with its efflux by the action of P-glycoprotein is, however, the major limitation. In this communication, the chemical approach of improving berberine’s bioavailability and pharmacological efficacy is scrutinised with specific reference to type-2 diabetes and associated diseases such as hyperlipidaemia and obesity. The application of modern delivery systems, research from combination studies to preparation of berberine structural hybrids with known biologically active compounds (antidiabetic, antihyperlipidaemic and antioxidant), as well as synthesis approaches of berberine derivative are presented. Improvement of bioavailability and efficacy through in vitro and ex vivo transport studies, as well as animal models of bioavailability/efficacy in lipid metabolism and diabetes targets are discussed.

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“…Moreover, anti-inflammatory and anti-oxidant effects have also been demonstrated by myricetin, eriodyctiol and galangin in retinal epithelial, ganglial and microglial cells, respectively [84,86,87]. In addition, baicalin protects human retinal pigment epithelial cells against hyperglycemic conditions by reducing the proliferative, anti-apoptotic and anti-inflammatory effects by up-regulation of miR-145 and further inhibition of NF-κB and p38 MAPK pathways [88].…”

Section: Diabetic Retinopathymentioning

confidence: 99%

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

Caro-Ordieres

Marín-Royo

Opazo-Ríos

et al. 2020

JCM

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Diabetes mellitus (DM), and its micro and macrovascular complications, is one of the biggest challenges for world public health. Despite overall improvement in prevention, diagnosis and treatment, its incidence is expected to continue increasing over the next years. Nowadays, finding therapies to prevent or retard the progression of diabetic complications remains an unmet need due to the complexity of mechanisms involved, which include inflammation, oxidative stress and angiogenesis, among others. Flavonoids are natural antioxidant compounds that have been shown to possess anti-diabetic properties. Moreover, increasing scientific evidence has demonstrated their potential anti-inflammatory and anti-oxidant effects. Consequently, the use of these compounds as anti-diabetic drugs has generated growing interest, as is reflected in the numerous in vitro and in vivo studies related to this field. Therefore, the aim of this review is to assess the recent pre-clinical and clinical research about the potential effect of flavonoids in the amelioration of diabetic complications. In brief, we provide updated information concerning the discrepancy between the numerous experimental studies supporting the efficacy of flavonoids on diabetic complications and the lack of appropriate and well-designed clinical trials. Due to the well-described beneficial effects on different mechanisms involved in diabetic complications, the excellent tolerability and low cost, future randomized controlled studies with compounds that have adequate bioavailability should be evaluated as add-on therapy on well-established anti-diabetic drugs.

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RETRACTED: Baicalin protects human retinal pigment epithelial cell lines against high glucose-induced cell injury by up-regulation of microRNA-145

Cited by 28 publications

References 34 publications

Retracted: Baicalin relieves TNF‐α‐evoked injury in human aortic endothelial cells by up‐regulation of miR‐145

Retracted: Baicalin relieves TNF‐α‐evoked injury in human aortic endothelial cells by up‐regulation of miR‐145

The Quest to Enhance the Efficacy of Berberine for Type-2 Diabetes and Associated Diseases: Physicochemical Modification Approaches

The Coming Age of Flavonoids in the Treatment of Diabetic Complications

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