Retracted: Chest digital dynamic radiography to detect changes in human pulmonary perfusion in response to alveolar hypoxia

Abstract

IntroductionHypoxic pulmonary vasoconstriction optimises oxygenation in the lung by matching the local‐blood perfusion to local‐ventilation ratio upon exposure to alveolar hypoxia. It plays an important role in various pulmonary diseases, but few imaging evaluations of this phenomenon in humans. This study aimed to determine whether chest digital dynamic radiography could detect hypoxic pulmonary vasoconstriction as changes in pulmonary blood flow in healthy individuals.MethodsFive Asian men underwent chest digital dynamic radiography before and after 60 sec breath‐holding at the maximal inspiratory level in upright and supine positions. Alveolar partial pressure of oxygen and atmospheric pressure were calculated using the blood gas test and digital dynamic radiography imaging, respectively. To evaluate the blood flow, the correlation rate of temporal change in each pixel value between the lung fields and left cardiac ventricles was analysed.ResultsSixty seconds of breath‐holding caused a mean reduction of 26.7 ± 6.4 mmHg in alveolar partial pressure of oxygen. The mean correlation rate of blood flow in the whole lung was significantly lower after than before breath‐holding (before, upright 51.5%, supine 52.2%; after, upright 45.5%, supine 46.1%; both P < 0.05). The correlation rate significantly differed before and after breath‐holding in the lower lung fields (upright, 11.8% difference; supine, 10.7% difference; both P < 0.05). The mean radiation exposure of each scan was 0.98 ± 0.09 mGy. No complications occurred.ConclusionsChest digital dynamic radiography could detect the rapid decrease in pulmonary perfusion in response to alveolar hypoxia. It may suggest hypoxic pulmonary vasoconstriction in healthy individuals.

Retracted: Chest digital dynamic radiography to detect changes in human pulmonary perfusion in response to alveolar hypoxia

“…The following article from Journal of Medical Radiation Sciences , ‘Chest digital dynamic radiography to detect changes in human pulmonary perfusion in response to alveolar hypoxia’, 1 published online on 13 September 2022 in Wiley Online Library ( http://onlinelibrary.wiley.com/ ), has been retracted by agreement between the journal Editor in Chief, Cherry Agustin and John Wiley and Sons, Australia. The retraction has been agreed due to unattributed overlap between Figure 3b as a conceptual figure in this article and the following article published in Radiological Physics and Technology , ‘Dynamic chest radiography: flat‐panel detector (FPD) based functional X‐ray imaging’ by R Tanaka, Volume 9, 2016, pages 139–153 2 .…”