RETRACTED: Downregulation of long noncoding RNA SNHG1 inhibits cell proliferation, metastasis, and invasion by suppressing the Notch‐1 signaling pathway in pancreatic cancer

Abstract

Background Pancreatic cancer (PC) has become the fourth most lethal among human cancers. Long noncoding RNAs (lncRNAs) have been reported to play a role in the progression of a variety of cancers. However, the role of lncRNA SNHG1 in PC is not clear. Methods Real‐time Quantitative PCR Detection System (qPCR) was used to detect the expression of SNHG1 in PC cells. Then, the SNHG1 knockdown cell was constructed with si‐SNHG1. AsPC‐1 and PANC1 cells were used to analyze the ability of cell proliferation, invasion, and migration. MTT assay was used to analyze the proliferation ability. Transwell experiments and wound healing experiments were used to detect the capacity of invasion and migration. Finally, Western blot analysis was used to explore the mechanism of SNHG1 in PC. Results SNHG1 was significantly upregulated in PC cells. Knockdown of SNHG1 could obviously suppress cell proliferation, invasion, and migration. Furthermore, SNHG1 knockdown inhibited the activation of the Notch‐1 signaling pathway and inhibited the expression of N‐cadherin, Hes1, Vimentin, Notch‐1. The inhabitation was reversed when Notch‐1 was overexpressed in si‐SNHG1 cells. Conclusion The lncRNA SNHG1 promotes cell growth and metastasis in PC through activation of the Notch‐1 signaling pathway in PC.

SNHG1 promotes proliferation, migration and invasion of bladder cancer cells via the PI3K/AKT signaling pathway

“…Moreover, Gao et al ( 20 ) revealed that lncRNA zinc finger E-box binding homeobox 2 AS1 increased the proliferation, migration and invasion, but reduced the apoptosis of bladder cancer cells as competing endogenous RNA sponges microRNA (miR)-200b to elevate the expression of fascin-1. Previous studies have also reported that SNHG1 serves important roles in the progression of cancer types, including NSCLC ( 21 ), glioma ( 9 ), pancreatic cancer ( 22 ), cholangiocarcinoma ( 23 ) and osteosarcoma ( 24 ).…”

LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/ HNF1A

“…Many studies have shown that the occurrence of invasion and metastasis in pancreatic cancer patients indicates a poor prognosis [15][16][17][18][19] . In our study, we used a series of experiments to obtain insight into the biological effects of LINC00673 in pancreatic cancer proliferation and metastasis.…”

The crosstalk between lncRNAs and the Hippo signalling pathway in cancer progression

“…SNHG1 was reported to be remarkably upregulated in several types of human malignancies such as osteosarcoma and laryngeal squamous cell carcinoma (LSCC) 84,86,87 . SNHG1 knockdown obviously impeded tumour cell proliferation, migration and invasion, while induced apoptosis via participating in pleiotropic cancer‐related signalling pathways, such as Notch, 88 Wnt/β‐catenin 87 and Hippo pathway 84 . Specifically, SNHG1 could serve as ceRNA to sponge to miR‐375 and thus promote YAP expression to regulate Hippo pathway in LSCC.…”