RETRACTED: Expression of the longevity proteins by both red and white wines and their cardioprotective components, resveratrol, tyrosol, and hydroxytyrosol

Mukherjee, Subhendu; Lekli, István; Gurusamy, Narasimman; Bertelli, A.; Das, Dipak K.

doi:10.1016/j.freeradbiomed.2008.11.005

Cited by 107 publications

(104 citation statements)

References 33 publications

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“…The use of olive oil in the diet is believed to be associated with a lower incidence of cancer and cardiovascular diseases in the Mediterranean population (Fabiani et al 2008;Visioli et al 1998). Activation of longevity proteins (SIRT and FoxO) in heart cells of hydroxytyrosol-fed rats suggests that hydroxytyrosol could impact aging (Mukherjee et al 2009). We have shown earlier that hydroxytyrosol inhibits age-associated increase in mitochondrial injury and extends chronological life span of fibroblasts .…”

Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation

Sarsour

Goswami

Kalen

et al. 2014

AGE

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Cancer is an age-associated disease. Although the mechanisms of age-associated increase in cancer incidence are not completely understood, it is believed that the tumor stromal environment significantly influences epithelial malignancy. Fibroblasts are a major cell type in the stroma and, under normal conditions, fibroblasts reside in the quiescent state. Cellular quiescence is a reversible process where cells enter into the proliferative cycle and then exit back to quiescence. We have shown previously that quiescent fibroblasts lose their proliferative capacity as they age, and we defined this mode of cellular aging as chronological life span. Using conditioned media and co-culture experiments, results from this study show that normal human fibroblasts (NHFs) nearing the end of their chronological life span stimulate the proliferation of MB231 and MCF7 human breast epithelial cancer cells. Chemokine C-C motif ligand 5 (CCL5) expression was found to be approximately 8-fold higher in old compared to that in young quiescent NHFs, which correlated with an increase in the ERK1/2-cyclin D1 pro-proliferative pathway in MB231 cells. Conditioned media treated with anti-CCL5 antibody suppressed the activation of the ERK1/2-cyclin D1 pathway and proliferation of MB231 cells. Hydroxytyrosol, a dietary polyphenol and an active ingredient of olive, inhibited CCL5 expression in aging quiescent NHFs. This inhibition was associated with NHFs inability to activate the ERK1/2-cyclin D1 pathway and enhance proliferation of MB231 cells. These results show that fibroblasts nearing the end of their chronological life span promote proliferation of human breast epithelial cancer cells and dietary polyphenols inhibit this process.

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Section: Discussionmentioning

confidence: 99%

Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation

Sarsour

Goswami

Kalen

et al. 2014

AGE

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“…As mentioned earlier, the first scientific evidence originated from the revolutionary observation that resveratrol similar to calorie restriction could activate Sirt1 gene [7,86,107]. Subsequent studies determined that resveratrol, wines and certain polyphenols could also induce Sirtuins, along with certain other longevity genes including FoxOs and PBEF [9]. More recent studies, however, have questioned the ability of resveratrol to increase life span [10].…”

Section: Resveratrol As An Anti-aging Compound: Fact or Fiction?mentioning

confidence: 99%

“…[101]. PBEF is associated with increased Sirtuin activity, suggesting that it could be linked with anti-aging component [9]. I PBEF is also highly expressed in visceral fat of diabetes and obese patients [102].…”

Section: Foxomentioning

confidence: 99%

Erratum to: Resveratrol and red wine, healthy heart and longevity

2011

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Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.

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“…(24) Experimentally, rats fed white wine had increased levels of the survival factor SirT-1, whereas those fed red wine had reduced cardiomyocyte apoptosis and infarct size. In human studies, Pinzani, et al (25) found that both white and red wines had similar effects in increasing the total antioxidant capacity levels in blood after 2h of ingestion red or white wine blood antioxidant capacity in humans.…”

Section: In Defence Of White Winesmentioning

confidence: 99%