Retracted: Expression Profile and Regulation of Telomerase Reverse Transcriptase on Oxygen-Induced Retinal Neovascularization

Min, Xiaojie; Zhou, Qingjun; Dong, Xiaoguang; Xie, Lixin

doi:10.3109/02713683.2010.525679

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…The retina contains potentially active telomerase, which can be implicated in functions other than telomere maintenance functions, including expression of retinal cell phenotypes [ 111 ]. Overexpression of the catalytic subunit of the enzyme was observed in a mouse model of retinopathy [ 112 ]. A high expression of telomerase observed in retinoblastoma is not surprising as it is considered as a major mechanism of cancer cell immortality [ 113 , 114 ].…”

Section: Melatonin In Amdmentioning

confidence: 99%

Melatonin in Retinal Physiology and Pathology: The Case of Age‐Related Macular Degeneration

Błasiak

Reíter

Kaarniranta

2016

Oxidative Medicine and Cellular Longevity

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Melatonin, an indoleamine, is synthesized mainly in the pineal gland in a circadian fashion, but it is produced in many other organs, including the retina, which seems to be especially important as the eye is a primary recipient of circadian signals. Melatonin displays strong antioxidative properties, which predispose it to play a protective role in many human pathologies associated with oxidative stress, including premature aging and degenerative disease. Therefore, melatonin may play a role in age-related macular degeneration (AMD), a disease affecting photoreceptors, and retinal pigment epithelium (RPE) with an established role of oxidative stress in its pathogenesis. Several studies have shown that melatonin could exert the protective effect against damage to RPE cells evoked by reactive oxygen species (ROS), but it has also been reported to increase ROS-induced damage to photoreceptors and RPE. Melatonin behaves like synthetic mitochondria-targeted antioxidants, which concentrate in mitochondria at relatively high levels; thus, melatonin may prevent mitochondrial damage in AMD. The retina contains telomerase, an enzyme implicated in maintaining the length of telomeres, and oxidative stress inhibits telomere synthesis, while melatonin overcomes this effect. These features support considering melatonin as a preventive and therapeutic agent in the treatment of AMD.

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Section: Melatonin In Amdmentioning

confidence: 99%

Melatonin in Retinal Physiology and Pathology: The Case of Age‐Related Macular Degeneration

Błasiak

Reíter

Kaarniranta

2016

Oxidative Medicine and Cellular Longevity

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Adenoviral Vector-Mediated Delivery of p21^WAF1/CIP1Prevents Retinal Neovascularization in an Oxygen-Induced Retinopathy Model

Han

2015

Current Eye Research

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Retracted: Expression Profile and Regulation of Telomerase Reverse Transcriptase on Oxygen-Induced Retinal Neovascularization

Cited by 2 publications

References 32 publications

Melatonin in Retinal Physiology and Pathology: The Case of Age‐Related Macular Degeneration

Melatonin in Retinal Physiology and Pathology: The Case of Age‐Related Macular Degeneration

Adenoviral Vector-Mediated Delivery of p21^WAF1/CIP1Prevents Retinal Neovascularization in an Oxygen-Induced Retinopathy Model

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Retracted: Expression Profile and Regulation of Telomerase Reverse Transcriptase on Oxygen-Induced Retinal Neovascularization

Cited by 2 publications

References 32 publications

Melatonin in Retinal Physiology and Pathology: The Case of Age‐Related Macular Degeneration

Melatonin in Retinal Physiology and Pathology: The Case of Age‐Related Macular Degeneration

Adenoviral Vector-Mediated Delivery of p21WAF1/CIP1Prevents Retinal Neovascularization in an Oxygen-Induced Retinopathy Model

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Adenoviral Vector-Mediated Delivery of p21^WAF1/CIP1Prevents Retinal Neovascularization in an Oxygen-Induced Retinopathy Model