[Retracted] Ginseng on Hyperglycemia: Effects and Mechanisms

Luo, John Zq; Luo, Liqiang

doi:10.1093/ecam/nem178

Cited by 79 publications

(42 citation statements)

References 51 publications

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“…Several health benefits of Rh2 have been reported due to its anti-inflammatory, antiGinsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells osteoclastogenic, anti-hyperglycemic and anticancer effects (10)(11)(12)(13)(14). The anticancer effect of Rh2 has been particularly observed in NSCLCs.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

An¹,

An²,

Kwon

et al. 2012

Oncology Reports

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Abstract. Non-small cell lung cancer (NSCLC) is the most common type of lung cancer insensitive to chemotherapy. Efforts are, therefore, directed toward understanding the molecular mechanisms of chemotherapy insensitivity and the development of new anticancer drugs. Ginsenoside Rh2, one of the components in ginseng saponin, has been shown to have anti-proliferative effect on human NSCLC cells and is being studied as a therapeutic drug for NSCLC. microRNAs (miRNAs) are small, non-coding RNA molecules that play a key role in cancer progression and prevention. However, the miRNA portrait of ginsenoside Rh2-treated NSCLC cells has not yet been studied. In this study, we identified a unique set of changes in the miRNA expression profile in response to Rh2 treatment in the human NSCLC cell line A549. Using miRNA microarray analysis, we identified 44 and 24 miRNAs displaying changes in expression greater than 2-fold in Rh2-treated A549 cells. In addition, using an miRNA target prediction program, we discovered that these miRNAs are predicted to have several target genes related to angiogenesis, apoptosis, chromatic modification, cell proliferation and differentiation. Thus, these results may assist in the better understanding of the anticancer mechanism of Rh2 in NSCLC.

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Section: Introductionmentioning

confidence: 99%

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

An¹,

An²,

Kwon

et al. 2012

Oncology Reports

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“…AMPK activation by polyphenols can explain their beneficial effects on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in type 1 diabetic LDL receptor deficient (LDLR -/-) mice (6). Panax ginseng is a widely used herbal medicine in Asian countries known to have anti-diabetic and anti-hyperlipidemic activities (7)(8)(9)(10)(11)(12). The principle components for these activities are thought to be the ginsenosides, a group of steroidal saponins.…”

Section: Introductionmentioning

confidence: 99%

Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice

Chung¹

2011

Int J Mol Med

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Abstract. Ginsenoside Re is a protopanaxatriol-type saponin isolated from Panax ginseng berry. Although anti-diabetic and anti-hyperlipidemic effects of Re have been reported by several groups, its mechanism of action is largely unknown until now. Here, we examine anti-diabetic and anti-hyperlipidemic activities of Re and action mechanism(s) in human HepG2 hepatocytes and high-fat diet fed C57BL/6J mice. Re suppresses the hepatic glucose production via induction of orphan nuclear receptor small heterodimer partner (SHP), and inhibits lipogenesis via suppression of sterol regulatory element binding protein-1c (SREBP-1c) and its target gene [fatty acid synthase (FAS), stearoyl-CoA desaturase-1 (SCD1)] transcription. These effects were mediated through activation of AMP-activated protein kinase (AMPK), and abolished when HepG2 cells were treated with an AMPK inhibitor, Compound C. C57BL/6J mice were randomly divided into five groups: regular diet fed group (RD), high-fat diet fed group (HFD) and the HFD plus Re (5, 10, 20 mg/kg) groups. Re treatment groups were fed a highfat diet for 6 weeks, and then orally administered Re once a day for 3 weeks. The in vitro results are likely to hold true in an in vivo experiment, as Re markedly lowered blood glucose and triglyceride levels and protected against hepatic steatosis in high-fat diet fed C57BL/6J mice. In conclusion, the current study suggest that ginsenoside Re improves hyperglycemia and hyperlipidemia through activation of AMPK, and confers beneficial effects on type 2 diabetic patients with insulin resistance and dyslipidemia.

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“…Auch aus dem Bereich der Phytotherapie sind verschiedene Pflanzen und aus Pflanzen isolierte Stoffe mit einem Blutglukose-regulierenden Effekt bekannt, darunter z.B. Zimt (Cinnamomum cassia) und Ginseng (Panax ginseng und Panax quinquefolius) [19,20], sodass die Phytotherapie besonders bei der Prävention und Therapie diabetischer Folgeerkrankungen viel zu bieten hat.…”

Section: Beispiele Von Phytotherapeutika Im Diabetes-managementunclassified

Das Potenzial von Padma<sup>®</sup> 28 bei Folgeerkrankungen des Diabetes mellitus

Vennos¹,

Uehlinger²

2010

Schweiz Z Ganzheitsmed

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Die Prävalenz von Diabetes mellitus Typ 2 und damit auch von diabetischen Folgeerkrankungen nimmt weltweit zu. Ausgehend von einer Hyperglykämie, häufig verstärkt durch Begleiterkrankungen wie Hypertonie und Adipositas, laufen verschiedene pathogene Prozesse ab. Durch Schädigung der Blutgefässe und der Zellversorgung führen diese zu diabetischen Folgeerkrankungen wie Herz-Kreislauf-Erkrankungen, peripherer arterieller Verschlusskrankheit, diabetischer Retino-, Nephro-und Neuropathie sowie zum diabetischen Fusssyndrom. Im Zentrum der Pathogenese stehen oxidativer Stress, die Bildung von «Advanced Glycation End Products» (AGE) und eine systemische, chronische Low-Level-Entzündung. Wegen der antioxidativen und antientzündlichen Effekte von sekundären Pflanzenstoffen scheint die Phytotherapie im Rahmen eines ganzheitlichen Diabetes-Behandlungskonzepts vielversprechende Ansätze zu bieten. Abgesehen von einem antihyperglykämischen Effekt, wie er z.B. von Zimtkassia oder Ginseng berichtet wurde, scheint ein besonders grosses Potenzial in der Prävention und Behandlung von diabetischen Folgeerkrankungen zu liegen. Phytotherapeutika wie etwa Traubenkernpolyphenole, Ginkgo biloba oder Padma^® 28 zeigten eine Hemmung verschiedener pathogener Prozesse. Am Beispiel der komplex zusammengesetzten Rezeptur Padma 28 werden Mechanismen aufgezeigt, wie sekundäre Pflanzenstoffe im Sinne eines Multi-Target-Ansatzes verschiedene pathogenetische Prozesse günstig beeinflussen können. Diese Hypothese wird gestützt durch Fallberichte mit Padma 28 bei Diabetesbedingten Parästhesien sowie durch klinische Studien mit dem Präparat, die eine Wirksamkeit bei Krankheitsbildern zeigen, welche auch als Folge von Diabetes auftreten. Antioxidative und antientzündliche Phytotherapeutika wie Padma 28 bieten deshalb wertvolle Behandlungsansätze in einem ganzheitlichen Diabetes-Management sowie in der Prävention und Behandlung von diabetischen Folgeerkrankungen.

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[Retracted] Ginseng on Hyperglycemia: Effects and Mechanisms

Cited by 79 publications

References 51 publications

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

Ginsenoside Rh2 mediates changes in the microRNA expression profile of human non-small cell lung cancer A549 cells

Ginsenoside Re lowers blood glucose and lipid levels via activation of AMP-activated protein kinase in HepG2 cells and high-fat diet fed mice

Das Potenzial von Padma<sup>®</sup> 28 bei Folgeerkrankungen des Diabetes mellitus

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