Recently, AI has been used in industry for very precise quality control of various products or in the automation of production processes through the use of trained artificial neural networks (ANNs) which allow us to completely replace a human in often tedious work or in hard-to-reach locations. Although the search for analytical formulas is often desirable and leads to accurate descriptions of various phenomena, when the problem is very complex or when it is impossible to obtain a complete set of data, methods based on artificial intelligence perfectly complement the engineering and scientific workshop. In this article, different AI algorithms were used to build a relationship between the mechanical parameters of papers used for the production of corrugated board, its geometry and the resistance of a cardboard sample to edge crushing. There are many analytical, empirical or advanced numerical models in the literature that are used to estimate the compression resistance of cardboard across the flute. The approach presented here is not only much less demanding in terms of implementation from other models, but is as accurate and precise. In addition, the methodology and example presented in this article show the great potential of using machine learning algorithms in such practical applications.