RETRACTED: Imidazolyl-PEI modified nanoparticles for enhanced gene delivery

Swami, Archana; Aggarwal, Anita; Pathak, Atul; Patnaik, Satyakam; Kumar, Pradeep; Singh, Yogendra; Gupta, Kailash C.

doi:10.1016/j.ijpharm.2006.11.033

Cited by 69 publications

(63 citation statements)

References 44 publications

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“…The Smoluchowski approximation was used to calculate the zeta potential from the electrophoretic mobility. 23 …”

mentioning

confidence: 99%

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Singh¹,

Bhatnagar²,

Mishra³

et al. 2015

IJN

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The clinical success of the applicability of tea polyphenols awaits efficient systemic delivery and bioavailability. Herein, following the concept of nanochemoprevention, which uses nanotechnology for enhancing the efficacy of chemotherapeutic drugs, we employed tea polyphenols, namely theaflavin (TF) and epigallocatechin-3-gallate (EGCG) encapsulated in a biodegradable nanoparticulate formulation based on poly(lactide-co-glycolide) (PLGA) with approximately 26% and 18% encapsulation efficiency, respectively. It was observed that TF/EGCG encapsulated PLGA nanoparticles (NPs) offered an up to ~7-fold dose advantage when compared with bulk TF/EGCG in terms of exerting its antiproliferative effects and also enhanced the anticancer potential of cisplatin (CDDP) in A549 (lung carcinoma), HeLa (cervical carcinoma), and THP-1 (acute monocytic leukemia) cells. Cell cycle analysis revealed that TF/EGCG-NPs were more efficient than bulk TF/EGCG in sensitizing A549 cells to CDDP-induced apoptosis, with a dose advantage of up to 20-fold. Further, TF/EGCG-NPs, alone or in combination with CDDP, were more effective in inhibiting NF-κB activation and in suppressing the expression of cyclin D1, matrix metalloproteinase-9, and vascular endothelial growth factor, involved in cell proliferation, metastasis, and angiogenesis, respectively. EGCG and TF-NPs were also found to be more effective than bulk TF/EGCG in inducing the cleavage of caspase-3 and caspase-9 and Bax/Bcl2 ratio in favor of apoptosis. Further, in vivo evaluation of these NPs in combination with CDDP showed an increase in life span ( P <0.05) in mice bearing Ehrlich’s ascites carcinoma cells, with apparent regression of tumor volume in comparison with mice treated with bulk doses with CDDP. These results indicate that EGCG and TF-NPs have superior cancer chemosensitization activity when compared with bulk TF/EGCG.

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“…The Smoluchowski approximation was used to calculate the zeta potential from the electrophoretic mobility. 23 …”

mentioning

confidence: 99%

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Singh¹,

Bhatnagar²,

Mishra³

et al. 2015

IJN

View full text Add to dashboard Cite

show abstract

“…3, bottom panel). In combination of IC 50 of CNP (1.61 g) for amastigotes, the CIs for 0.25, 0.5, and 1.0 g of miltefosine were 1.055, 0.852, and 0.885, respectively, indicating a nearly additive effect at 0.25 g and slight synergisms at 0.5 and 1 g of miltefosine.…”

Section: Resultsmentioning

confidence: 99%

“…3, top panel). The combination indices (CIs) for 1.34 g of CNP (IC 50 ) with different miltefosine concentrations were 0.563 (0.125 g), 0.426 (0.25 g), 0.355 (0.5 g), and 0.382 (1.0 g), whereas the CIs for 0.125, 0.25, 0.5, and 1.0 g of miltefosine with 0.67 g of CNP were 0.470, 0.335, 0.271, and 0.309, respectively. All these doses illustrated significant synergism.…”

Section: Resultsmentioning

confidence: 99%

“…Characterization of CNPs. For the dynamic light scattering (DLS) analyses, the mean particle size and zeta potential of CNPs were determined using Zetasizer Nano-ZS (Malvern Instruments, Malvern, United Kingdom) employing a nominal 5-mW He-Ne laser operating at 633-nm wavelength in accordance with the established method (50). For the assessment, the formulation (0.5 mg/ml) was dispersed in water and sonicated for 5 min (30% amplitude, 45 s:15 s pulse on/pulse off).…”

Section: Parasite L Donovani Promastigotes (Who Designation Mhom/inmentioning

confidence: 99%

“…The in vitro effect of miltefosine and the nanoformulation of curcumin on the growth of promastigotes was assessed by monitoring the luciferase activity of viable cells after treatment (47). The transgenic late-log-phase promastigotes were seeded at 5 ϫ 10 5 cells/well in 96-well flat-bottomed microtiter plates (Cellstar; Greiner Bio-One GmbH, Monroe, NC), followed by incubation for 72 h in medium in the absence (control) or presence of serial dilutions of antileishmanial agents alone (10 ng to 10 g) or in combination (IC 50 or half of IC 50 concentration of CNP and different concentrations of miltefosine). Nanoformulations (CNP) were suspended in water and sonicated for 3 min (30% amplitude, 50:10 pulse on/pulse off).…”

Section: Parasite L Donovani Promastigotes (Who Designation Mhom/inmentioning

confidence: 99%

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Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis

Tiwari

Pahuja

Kumar

et al. 2017

Antimicrob Agents Chemother

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Leishmaniasis chemotherapy remains very challenging due to high cost of the drug and its associated toxicity and drug resistance, which develops over a period of time. Combination therapies (CT) are now in use to treat many diseases, such as cancer and malaria, since it is more effective and affordable than monotherapy. CT are believed to represent a new explorable strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite Leishmania. In the present study, we investigated the effect of a combination of a traditional Indian medicine (ayurveda), a natural product curcumin and miltefosine, the only oral drug for visceral leishmaniasis (VL) using a Leishmania donovani-hamster model. We developed an oral nanoparticle-based formulation of curcumin. Nanoformulation of curcumin alone exhibited significant leishmanicidal activity both in vitro and in vivo. In combination with miltefosine, it exhibited a synergistic effect on both promastigotes and amastigotes under in vitro conditions. The combination of these two agents also demonstrated increased in vivo leishmanicidal activity accompanied by increased production of toxic reactive oxygen/nitrogen metabolites and enhanced phagocytic activity. The combination also exhibited increased lymphocyte proliferation. The present study thus establishes the possible use of nanocurcumin as an adjunct to antileishmanial chemotherapy.

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Mini Review of TiO₂‐Based Multifunctional Nanocomposites for Near‐Infrared Light–Responsive Phototherapy

Wang

Hou

Kheraif

et al. 2018

Adv Healthcare Materials

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Phototherapy with the properties of specific spatial/temporal selectivity and minimal invasiveness has been acknowledged as one of the most promising cancer therapy types. Among all the photoactive substance for phototherapy, titanium dioxide (TiO ) nanomaterials are paid more and more attention due to their outstanding photocatalytic properties, prominent biocompatibility, and excellent chemical stability. However, the wide bandgap (3.0-3.2 eV) of TiO limits its absorption only to the ultraviolet (UV) light region. For a long time, UV light-stimulated TiO was applied in the phototherapy researches of tumors located in the skin layer, while it is unsatisfactory for most deep-tissue tumors. Due to the maximum penetration into tissue existing in the near-infrared (NIR) region, how to use NIR light to trigger photochemical reaction of TiO remains a big challenge. In this review, two strategies to develop and construct NIR-triggered TiO -based nanocomposites (NCs) for phototherapy are summarized, and the relevant mechanism and background knowledge of TiO -based phototherapy are also given in order to better understand the application value and current situation of TiO in phototherapy. Finally, the challenges and research directions of TiO in the future clinic phototherapy application are also discussed.

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RETRACTED: Imidazolyl-PEI modified nanoparticles for enhanced gene delivery

Cited by 69 publications

References 44 publications

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis

Mini Review of TiO₂‐Based Multifunctional Nanocomposites for Near‐Infrared Light–Responsive Phototherapy

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RETRACTED: Imidazolyl-PEI modified nanoparticles for enhanced gene delivery

Cited by 69 publications

References 44 publications

PLGA-encapsulated tea polyphenols enhance the&nbsp;chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-encapsulated tea polyphenols enhance the&nbsp;chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Nanotized Curcumin and Miltefosine, a Potential Combination for Treatment of Experimental Visceral Leishmaniasis

Mini Review of TiO2‐Based Multifunctional Nanocomposites for Near‐Infrared Light–Responsive Phototherapy

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Product

Resources

About

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

PLGA-encapsulated tea polyphenols enhance the chemotherapeutic efficacy of cisplatin against human cancer cells and mice bearing Ehrlich ascites carcinoma

Mini Review of TiO₂‐Based Multifunctional Nanocomposites for Near‐Infrared Light–Responsive Phototherapy