Retracted: Iron Oxide Nanoparticles: Preparation, Characterization, and Assessment of Antimicrobial and Anticancer Activity

Abstract

Nanotechnology and nanoparticles (NPs) have increasingly been studied as an alternative for antibiotics because of the feasibility to be used in implantable devices both for bacterial detection and infection prevention. The low rate of resistance development against NPs because of its multiple mode of action has contributed to its increased acceptance in clinical setting. Further development of NPs and their anticancer activity against many human cancer cell lines including breast and ovarian have been documented. Fe2O3-NPs could be used for antibacterial and anticancer activity assessment. Iron oxide, apart from being available extensively and cheap, also plays a role in multiple biological processes, making it an interesting metal for NPs. The aim of the present study revolves around generation and characterization of iron oxide Fe2O3-NPs, followed by assessment of its antimicrobial and anticancer activities. Synthesis of Fe2O3-NPs was performed by hydrothermal approach, and its characterization was done by UV-visible, X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) analyses, and transmission electron microscopy (TEM). Antimicrobial activity was checked by agar diffusion assay against Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, and Candida albicans. Anticancer activity of the NPs was assessed using the human cancer cell lines including cervical carcinoma cell line (HeLa) and MCF7. The developed Fe2O3-NPs exhibited a characteristic absorption curve in the 500-600 nm wavelength range by UV-visible analysis, the XRD peaks were found to index the rhombohedral shape, and the FTIR analysis ascertained the bonds and functional groups at wavenumber from 400 to 4000 cm-1. Antimicrobial assay detected significant effect against Staphylococcus aureus and Bacillus subtilis with zones of inhibition: 21 and 22 mm, respectively. Likewise, Fe2O3-NPs show good activity towards tested fungal strain Candida albicans with zone of inhibition of 24 mm. The 2,5-diphenyl-2H-tetrazolium bromide (MTT) assay identified significant anticancer activity of the NPs against both cell lines. Our study documents the successful generation and characterization of Fe2O3-NPs having excellent antimicrobial and anticancer activities.

Environmentally azithromycin pharmaceutical wastewater management and synergetic biocompatible approaches of loaded azithromycin@hematite nanoparticles

“…Our approach showed excellent and satisfactory results as an antibacterial agent compared with a recent study reported by Alangari et al . 55 where they used a concentration of 100 μL of the prepared α-HNPs against E. coli , B. subtilis , P. aeruginosa , and S. aureus . Where our α-HNPs and Azr @ α-HNPs system manifested high potent against the same bacterial pathogenic species.…”

“…Also, in a similar study using the hydrothermal approach as the green synthesis of α-HNPs , the anticancer activity against the HepG2, HeLa, and MCF7 cell lines were implemented showing the IC 50 71 μg/mL, 68.12 μg/mL, and 53.35 μg/mL respectively for the tested cell lines 55 . These findings confirmed the anticancer activities of the α-HNPs and their loaded nanosystem.…”

Development and Evaluation of Chitosan Nanoparticles for Ocular Delivery of Tedizolid Phosphate

“…Testing of the antimicrobial activity of the F2 and TZP AqS was performed by the agar diffusion method [ 47 , 48 ]. Bacterial strains for the assessment were obtained from the Department of Pharmaceutics, College of Pharmacy, King Saud University.…”

Green Synthesis and Antibacterial Activity of Ag/Fe2O3 Nanocomposite Using Buddleja lindleyana Extract

“…Leaf extract-mediated synthesis of Fe 2 O 3 NPs is gaining the attention of researchers because of its lower toxicity compared to other chemical reduction methods [ 28 ]. Due to their potential utility in targeted drug administration and magnetic hyperthermia cancer treatment, extensive study has been completed on the anticancer properties of Fe 2 O 3 NPs [ 60 , 61 , 62 , 63 ]. There have been very few reports of investigations on the creation of Ag/Fe 2 O 3 NPs.…”