RETRACTED: Long non-coding RNA HULC promotes UVB-induced injury by up-regulation of BNIP3 in keratinocytes

Zhao, Li; Man, Yigang; Liu, Shumei

doi:10.1016/j.biopha.2018.05.100

Cited by 18 publications

(9 citation statements)

References 29 publications

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“…sne is by ROS generated immediately after the irradiation and the other is by reactive nitrogen species in the later time point [37]. As a result, even with a single and momentary exposure to UVB, the viability of the exposed cells decreases in the course of time [36].…”

Section: Discussionmentioning

confidence: 99%

“…H 2 O 2 can penetrate the cell easily, but it is also reduced rapidly by the antioxidative mechanism [29]. On the other hand, UVB has a lingering effect on the cells by directly damaging DNA, causing gene mutation, and modifying gene expression, and enzyme activity along with increasing ROS level [36]. UVB-induced damage is mediated by two different pathways.…”

Section: Discussionmentioning

confidence: 99%

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Antioxidative Effects of Ascorbic Acid and Astaxanthin on ARPE-19 Cells in an Oxidative Stress Model

Kim

Lee

et al. 2020

Antioxidants

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Oxidative stress has been implicated as critical pathogenic factors contributing to the etiology of diabetic retinopathy and other retinal diseases. This study investigated antioxidative effect of ascorbic acid and astaxanthin on ARPE-19 cells within an oxidative stress model induced by common biological sources of reactive oxygen species (ROS). Hydrogen peroxide (H2O2) at concentrations of 0.1–0.8 mM and 20–100 mJ/cm2 of ultraviolet B (UVB) were treated to ARPE-19 cells. Cell viability and intracellular ROS level changes were measured. With the sublethal and lethal dose of each inducers, 0–750 μM of ascorbic acid and 0–40 μM of astaxanthin were treated to examine antioxidative effect on the model. Ascorbic acid at concentrations of 500 and 750 μM increased the cell viability not only in the UVB model but also in the H2O2 model, but 20 and 40 μM of astaxanthin only did so in the UVB model. The combination of ascorbic acid and astaxanthin showed better antioxidative effect compared to each drug alone, suggesting a synergistic effect.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antioxidative Effects of Ascorbic Acid and Astaxanthin on ARPE-19 Cells in an Oxidative Stress Model

Kim

Lee

et al. 2020

Antioxidants

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“…The ASCs secretome contains exosomes and microvesicles, which may secrete yet unknown factors that may interfere with the biological processes of the host tissue. Thus, these compounds need to be studied in depth to generate more knowledge about the complexity of their actions for future application of cell-free therapy [ 33 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

Cell-free therapy with the secretome of adipose tissue-derived stem cells in rats’ frozen-thawed ovarian grafts

et al. 2018

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The use of secretome may be a new strand of cell therapy, which is equal to or even superior to the injection of live cells, called cell-free therapy. In ovarian transplantation, this approach may be a therapeutic possibility for the ovarian graft in hypoxia. We designed the present study to evaluate whether the cell-free therapy with the secretome of adipose tissue-derived stem cells (ASCs) in rat frozen-thawed ovarian grafts could protect a graft against ischemic injury. A single dose of rat ASCs secretome or vehicle was injected into the bilateral frozen-thawed ovaries of 18 adult female rats immediately after an autologous transplant. Nine animals were used to control the cryopreservation protocol and were evaluated before and after the cryopreservation process. Daily vaginal smears were performed for estrous cycle evaluation until euthanasia on postoperative day 30. Follicle viability by trypan blue, graft morphology by HE, and apoptosis by TUNEL and cleaved-caspase-3 were assessed. No differences were found with respect to estrous cycle resumption and follicle viability (p > 0.05). However, compared with the vehicle-treated grafts, the morphology of the secretome-treated grafts was impaired, showing reduced follicular population and increased apoptosis (p < 0.05). ASC secretome impaired the rat frozen-thawed ovarian graft from ischemic injury. However, more studies are needed to evaluate the factors involved and the possibility of applying the secretome in scaffolds to optimize its use.Electronic supplementary materialThe online version of this article (10.1186/s13287-018-1054-3) contains supplementary material, which is available to authorized users.

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“…The induction of lincRNA-21 by UVB irradiation was primarily through a p53-dependent pathway and had a proapoptotic function in keratinocytes [18]. It is reported that HULC promoted UVB-induced cell injury via the activation of JAK/STAT (1/3) signaling pathway in HaCaT cells [19]. HOTAIR resulted in apoptosis and inflammation in UVB-exposed keratinocytes [20].…”

Section: Introductionmentioning

confidence: 98%

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

Wang

et al. 2020

BioMed Research International

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Long noncoding RNAs (lncRNAs) are a class of noncoding RNAs that modulate gene expression, thereby participating in the regulation of various cellular processes. However, it is not clear about the expression and underlying mechanism of lncRNAs in irradiation-induced DNA damage response. In the present study, we performed integrative analysis of lncRNA-mRNA expression profile in human lymphocytes irradiated with ultraviolet-C (UVC). The results showed that exposure to UVC irradiation dose-dependently increased the fluorescence intensity of γ-H 2 AX and induced cell death. Microarray analysis revealed that up-regulated lncRNAs were more common than down-regulated lncRNAs with the increase of radiation dose in UVC-radiated cells. Stem analysis demonstrated the relationship between lncRNA expression level and radiation dose. qPCR results confirmed that LOC338799 and its coexpressed genes such as LCE1F and ISCU showed the increase in expression levels with the increase of UVC radiation dose. We utilized Cytoscape to screen out 5 lncRNAs and 13 coexpressed genes linking to p53, which might participate in the regulation of DNA damage, cell cycle arrest, apoptosis, and cell death. These findings suggest that lncRNAs might play a role in UVC-induced DNA damage response through regulating expression of genes in p53 signaling pathway.

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RETRACTED: Long non-coding RNA HULC promotes UVB-induced injury by up-regulation of BNIP3 in keratinocytes

Cited by 18 publications

References 29 publications

Antioxidative Effects of Ascorbic Acid and Astaxanthin on ARPE-19 Cells in an Oxidative Stress Model

Antioxidative Effects of Ascorbic Acid and Astaxanthin on ARPE-19 Cells in an Oxidative Stress Model

Cell-free therapy with the secretome of adipose tissue-derived stem cells in rats’ frozen-thawed ovarian grafts

The Potential Regulatory Roles of lncRNAs in DNA Damage Response in Human Lymphocytes Exposed to UVC Irradiation

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