RETRACTED: Long Noncoding RNA UCA1 Regulates PRL-3 Expression by Sponging MicroRNA-495 to Promote the Progression of Gastric Cancer

Abstract

Gastric cancer (GC) is among the most frequently occurring malignancies worldwide. In recent years, long noncoding RNAs (lncRNAs) have been widely studied because of their ability to regulate the cellular processes involved with tumorigenesis. The present study aims to investigate the underlying molecular mechanism by which lncRNA urothelial carcinoma-associated 1 (UCA1) influences the progression of GC. Differentially expressed lncRNA UCA1 was initially identified by microarray-based analysis, after which a high expression of UCA1 was determined in GC tissues and cells. It is important to note that UCA1 could upregulate the expression of phosphatase of regenerating liver-3 (PRL-3) by sponging miR-495. The expression of UCA1 and miR-495 was altered in human GC cells to evaluate cell activity in vitro, as well as peritoneal metastasis and tumor formation ability in vivo. Results suggested that increased expression of UCA1 promoted cell proliferation, migration, and invasion, accompanied by suppressed cell apoptosis, as well as enhanced peritoneal metastasis and tumorigenesis of GC cells. Meanwhile, the upregulated expression of miR-495 could reverse the promotive effects exerted by UCA1. Taken conjointly, UCA1, as a competing endogenous RNA (ceRNA) of miR-495, could accelerate the development of GC by upregulating PRL-3, highlighting a potentially promising basis for the targeted intervention treatment of GC.

LINC01006 facilitates cell proliferation, migration and invasion in prostate cancer through targeting miR-34a-5p to up-regulate DAAM1

“…LncRNA RHPN1-AS1 has been claimed to accelerate the breast cancer development [9]. UCA1/miR-495/PRL-3 axis results in cell proliferation in gastric cancer [10].…”

Knockdown of lncRNA LINC01234 suppresses the tumorigenesis of liver cancer via sponging miR-513a-5p

“…However, liver cancer patients are usually diagnosed at advanced stages, so they often miss the optimal opportunity for surgical resection (4). Furthermore, liver cancer is highly resistant to conventional chemotherapy and radiation therapy (5,6). Currently, clinicopathologic prognostic factors include TNM stage, tumor size, microvascular invasion, tumor rupture, underlying cirrhosis, and multi-focality (7).…”

LINC01006 influences cell proliferation, apoptosis, migration and invasion by targeting miR-34a-5p/DAAM1 in prostate cancer

“…RHPN1-AS1 was reported to promote the progression of breast cancer by targeting miR-6884-5p/ANXA11 [9]. UCA1 contributed to the proliferation in gastric cancer through modulating PRL-3 expression and sponged miR-495 [10]. Long intergenic non-protein coding RNA 1006 (LINC01006) was studied as an underlying biomarker in gastric cancer [11].…”