RETRACTED: Physicochemical characterization, in vitro and in vivo evaluation of chitosan/carrageenan encumbered with Imatinib mesylate-polysarcosine nanoparticles for sustained drug release and enhanced colorectal cancer targeted therapy

Bhattacharya, Subhamoy; Bonde, Smita; Hatware, Ketan; Sharma, Surya Prakash; Anjum, Md Meraj; Sahu, Ram Kumar

doi:10.1016/j.ijbiomac.2023.125529

Cited by 19 publications

(4 citation statements)

References 54 publications

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“…A recent study by Bhattacharya et al [ 89 ] focused on developing chitosan–carrageenan nanoparticles for the delivery of imatinib mesylate-poly sarcosine. Based on the experimental results, the authors concluded that these polysaccharide-based nanosystems are promising for the treatment of colon cancer, having great potential in actively targeting and reducing the dose-dependent toxicity of the carried drug.…”

Section: Drug Delivery Systems Based On Chitosan/cyclodextrins For Th...mentioning

confidence: 99%

“…The opposite situation was observed for chitosan-based vehicles employed in colorectal cancer treatment, as the mucoadhesion and pH-sensitivity of this material attracted more interest towards developing orally administered chemotherapeutics [ 83 , 85 , 86 , 90 , 92 ]. On the other hand, creating chitosan-based delivery vehicles for intravenous administration imposed different targeting strategies, such as the use of folic acid to ensure selectivity towards cells with overexpressed folate receptors [ 82 ], loading with an imatinib mesylate drug that acts as a tyrosine kinase inhibitor, with specific targets of BCR-ABL and c-KIT kinases [ 89 ], and creating composites with magnetic nanoparticles to be guided under the application of an external magnetic field [ 93 , 94 ]. Regarding gastric cancer, only one of the proposed formulations was designed for oral administration considering the mucoadhesion of chitosan [ 120 ], whereas other carriers were developed to be injected intravenously (with targeting based on chitosan’s intrinsic properties [ 117 , 123 ] and the addition of GX1 as a targeting ligand [ 122 ]), intraperitoneally [ 119 ], and subcutaneously [ 121 ].…”

Section: Drug Delivery Systems Based On Chitosan/cyclodextrins For Th...mentioning

confidence: 99%

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Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers

Najm,

Niculescu,

Bolocan

et al. 2023

Pharmaceutics

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Gastrointestinal cancers are characterized by a frequent incidence, a high number of associated deaths, and a tremendous burden on the medical system and patients worldwide. As conventional chemotherapeutic drugs face numerous limitations, researchers started to investigate better alternatives for extending drug efficacy and limiting adverse effects. A remarkably increasing interest has been addressed to chitosan and cyclodextrins, two highly versatile natural carbohydrate materials endowed with unique physicochemical properties. In this respect, numerous studies reported on fabricating various chitosan and cyclodextrin-based formulations that enabled prolonged circulation times, improved cellular internalization of carried drugs, preferential uptake by the targeted cells, reduced side effects, enhanced apoptosis rates, and increased tumor suppression rates. Therefore, this paper aims to briefly present the advantageous properties of these oligo- and polysaccharides for designing drug delivery systems, further focusing the discussion on nanocarrier systems based on chitosan/cyclodextrins for treating different gastrointestinal cancers. Specifically, there are reviewed studies describing promising solutions for colorectal, liver, gastric, pancreatic, and other types of cancers of the digestive system towards creating an updated framework of what concerns anticancer chitosan/cyclodextrin-based drug delivery systems.

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Section: Drug Delivery Systems Based On Chitosan/cyclodextrins For Th...mentioning

confidence: 99%

Section: Drug Delivery Systems Based On Chitosan/cyclodextrins For Th...mentioning

confidence: 99%

Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers

Najm,

Niculescu,

Bolocan

et al. 2023

Pharmaceutics

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“…The traditional methods of rehabilitation have been mainly manual therapy and walking aids. However, in practice this may not always lead to the best outcomes [1]- [4]. Additionally, it's often difficult and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Development of an Elderly Care Rehabilitation System Utilizing Machine Learning for Energy Monitoring and Transmission using Wireless Sensor Networks

S. Srinivasan

2024

jes

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The combination of robotic exoskeleton systems and machine learning (ML) techniques present great potential for significantly improving rehabilitation outcomes in patients with mobility impairments. This particular study examines whether ML algorithms can predict torque and angular inputs required for joint rotation using electromyography (EMG) data obtained during patient lower-limb rehabilitation. A new exoskeleton was designed for personalized and adaptable assistance in rehabilitation of walking. The predictive power of four different ML models, Artificial Neural Network (ANN), k-Nearest Neighbors (KNN), Decision Trees (DT), and Support Vector Machines (SVM), is evaluated. Of these, the ANN model is the most effective with an accuracy rate of 98.87%, followed by KNN (94.55%), DT (91.2%) and SVM (89.45%). Subsequent patient tests confirm significant improvements in flexion and extension angles of the knee, suggesting improved mobility and restored natural gait mechanics. These results stress the potential uses of ML-enhanced exoskeleton systems in personalised rehabilitation therapy. Proposals for further work include improving model performance, tackling challenges for real-time processing, and evaluating ML performance over the long term as it affects the quality of life in individuals with mobility impairments or changes in their condition over time. This investigation into rehabilitation aims at applying technology-driven solutions to help people regain their freedom and ability to move in a way that pleases them.

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“…Occupational therapy goes a step further and is more involved in everyday activities and exercises. Constraint-induced movement therapy is a procedure where one of the arms is restrained to make sure the other one is used instead of the unaffected arm [4]- [6]. It is designed to help potentially recover lost functions in a more direct way.…”

Section: Introductionmentioning

confidence: 99%

Machine learning and IoT Based Robotic Solution for Home Wrist Rehabilitation through Motion Capture Enabled Architecture

Ch. Gangadhar

2024

jes

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The present study investigates the effectiveness of an integrated approach that combines machine learning, robotic rehabilitation, and traditional methods for wrist rehabilitation among the hemiparesis population. Subjects with robotic rehabilitation at the four-week intervention period showed the ball’s significant difference in the flexion and extension angles and demonstrated the better overall outcomes from the robotic intervention . The machine learning models, in particular, the artificial neural networks, provided the prediction of rehabilitation outcomes and demonstrated the high accuracy, high precision, high recall, and high F1 score. This study supports the idea of the beneficial effects of combining robotic rehabilitation with machine learning algorithms and supports the notion that the two benefits could bring high synergistic effects above their individual potentials. The report also contributes to the development of the rehabilitation science of wrists, given that few studies have explored the applications of artificial intelligence methods or robotic rehabilitation beyond the context of feasibility reports. The findings of the current research could contribute useful insights for the decision-making practices of therapists and healthcare providers, also given the reliance on large data contributed by the previous interventions. Future study could investigate the long-term results, the cost-effectiveness of the approaches, and assist in developing the potential results of customization for individual patients.

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RETRACTED: Physicochemical characterization, in vitro and in vivo evaluation of chitosan/carrageenan encumbered with Imatinib mesylate-polysarcosine nanoparticles for sustained drug release and enhanced colorectal cancer targeted therapy

Cited by 19 publications

References 54 publications

Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers

Chitosan and Cyclodextrins—Versatile Materials Used to Create Drug Delivery Systems for Gastrointestinal Cancers

Development of an Elderly Care Rehabilitation System Utilizing Machine Learning for Energy Monitoring and Transmission using Wireless Sensor Networks

Machine learning and IoT Based Robotic Solution for Home Wrist Rehabilitation through Motion Capture Enabled Architecture

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