RETRACTED: Study on Hypoglycemic Effect of Mulberry Leaf Extract Based on Big Data analysis

Abstract

With the improvement of people’s living standards and the emergence of aging society, the incidence of diabetes is increasing year by year, and diabetes and its complications have become the third killer threatening human health. There are many drugs for treating diabetes, but their toxic and side effects are all great. Therefore, using big data analysis to find and develop natural products with hypoglycemic effect has high practical value. Therefore, the purpose of this paper is to study the hypoglycemic effect of mulberry leaf extract based on big data analysis. Firstly, this paper studies the medicinal value of mulberry leaves and related application methods by consulting relevant data. Through big data analysis, it is found that mulberry leaves are rich in alkaloid component 1-deoxynojirimycin (DNJ), accounting for more than 50% of alkaloid content. Therefore, this paper takes mulberry leaf extract DNJ as the research object, and firstly prepares mulberry leaf extract. Mulberry leaf water extract was perfused into stomach for 15 consecutive days, and fasting blood glucose of diabetic mice was measured 2 hours after eating by glucose oxidase method at specified time. The hypoglycemic effect of mulberry leaf water extract was analyzed by big data. The results showed that mulberry leaf extract could effectively inhibit the enzyme activity of decomposing sugar and prevent glucose absorption. Therefore, it can significantly reduce the blood sugar level of diabetic mice by about 50%. And the higher the dose of mulberry leaf extract, the better the hypoglycemic effect, showing a dose effect.

Effect of the Replacement of Maize Silage and Soyabean Meal with Mulberry Silage in the Diet of Hu Lambs on Growth Performance, Serum Biochemical Indices, Slaughter Performance, and Meat Quality

“…Mulberry leaves contain a variety of bioactive components, among which 1-deoxynojirimycin (1-DNJ), the main active alkaloid substance, is a glycosidase inhibitor that can significantly improve the glucose utilization efficiency and reduce blood glucose levels [ 30 ]. GLU is the main energy source of the body, and its content changes show a dynamic balance, reflecting the synthesis and metabolism of carbohydrates in the body and affecting muscle lipid metabolism and protein conversion, thereby improving meat quality [ 31 ].…”

Applications of Mulberry Leaves: An Overview

“…Other polyhydroxy alkaloids present in mulberry are methylpyrrolidine carboxylic acid, cis-and trans-5-Hydroxypipecolic acids as well as pipecolic acid (Rodríguez-Sánchez et al, 2011) attributed to them (Parida et al, 2023). DNJ, a major polyhydroxylated alkaloids of mulberry leaves (1.389−3.483 mg.g -1 ) that accounts for almost 50% of the mulberry alkaloids (Liu et al, 2020;Yang et al, 2021). DNJ is a potential antihyperglycaemic compound in mulberry leaves as it inhibits glucosidase, suppress abnormally high level of blood glucose and prevent diabetes mellitus (Ramappa et al, 2020;Tang et al, 2023).…”