RETRACTED: The impact of sarcopenia on prognosis of patients with pancreatic cancer: A systematic review and meta-analysis

Abstract

Objective To summarize recent findings on the association of low skeletal muscle mass and muscle quality with overall survival and recurrence-free survival in patients with pancreatic cancer. Methods A systematic search was conducted using Medline (via PubMed), Embase and Scopus databases for observational studies reporting on the overall survival and recurrence-free survival. Pooled effect sizes were reported as hazards ratio along with 95% confidence intervals. Results A total of 34 studies were included. Low skeletal muscle index (indicating muscle mass) was associated with poor overall survival (hazards ratio: 1.50; 95% confidence interval: 1.34, 1.67) and lower recurrence-free survival (hazards ratio: 1.28, 95% confidence interval: 1.15, 1.43). Low skeletal muscle attenuation (indicating muscle quality) was associated with poor overall survival (hazards ratio: 1.32; 95% confidence interval: 1.05, 1.66). Recurrence-free survival was similar in patients with low and normal/high skeletal muscle attenuation (hazards ratio: 1.12, 95% confidence interval: 0.89, 1.40). Conclusion Both low skeletal muscle mass and poor muscle quality are associated with poor long-term survival. Low skeletal muscle index, but not low skeletal muscle attenuation, are associated with poor recurrence-free survival.

Retraction of manuscripts: An exercise to ensure scholarly correctness and academic integrity

“…The remaining part of the issue has some more papers on evidence synthesis. Gan et al 2 have summarised impact of sarcopenia on the outcome of pancreatic cancer. The term ‘sarcopenia’, originates from Greek language.…”

Sarcopenia as a prognostic indicator in colorectal cancer: an updated meta-analysis

“…Meyer et al found that sarcopenia was a prognostic marker for survival in gastric cancer undergoing palliative chemotherapy (13). Additionally, Gan H et al pointed out both low skeletal muscle mass and poor muscle quality were relative with poor long term survival of patients with pancreatic cancer (14). The Computed tomography (CT) scans enable the measurement of the third lumbar spine skeletal muscle index (L3-SMI).…”

Systematic reviews and data analyses: Guide to clinical practice and research

“…The range of topics of systematic reviews. [1][2][3][4][5][6][7][8] in this issue has been wide and not focusing on a particular problem, however, publications should generate awareness, some glimpse into methodology and associated discussions around evidence-based medicine.Evidence-based medicine is a combination of individual clinical knowledge and the results of clinical trials. And as a doctor, there is a great need for some strong evidence to support his diagnosis and treatment and all aspects of it.…”

“…The range of topics of systematic reviews. [1][2][3][4][5][6][7][8] in this issue has been wide and not focusing on a particular problem, however, publications should generate awareness, some glimpse into methodology and associated discussions around evidence-based medicine.…”