[Retracted] The Relationship between the Mean Platelet Volume and Carotid Atherosclerosis and Prognosis in Patients with Acute Cerebral Infarction

Xu, Min; He, Xiaoying; Huang, Pan

doi:10.1155/2020/6685740

Cited by 17 publications

(8 citation statements)

References 23 publications

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“…Acute cerebral infarction is a local, cerebral, blood supply disorder. Caused by a variety of reasons, it can lead to cerebral ischemia and hypoxia, with the corresponding clinical manifestations of neurological dysfunction (13).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of collateral circulation and short-term prognosis of patients with acute cerebral infarction by perfusion-weighted MRI

Shang¹,

Zhang²,

Li³

et al. 2022

Ann Palliat Med

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Background: Perfusion-weighted magnetic resonance imaging (MRI) can evaluate collateral circulation in patients with acute cerebral infarction by reflecting hemodynamic signals in the brain. The purpose of this study was to evaluate the collateral circulation and short-term prognosis of patients with acute cerebral infarction, using perfusion-weighted MRI. Methods:The study enrolled 206 patients with acute cerebral infarction due to unilateral cerebral artery occlusion diagnosed by digital subtraction angiography (DSA) and computed tomography angiography (CTA). The relative cerebral blood volume (rCBV), relative cerebral blood flow map (rCBF), relative peak time (rTTP), and relative mean transit time (rMTT) were calculated based on the ratio of the perfusionweighted MRI reference values of the infarcted side and the control side of the patient. According to the results of perfusion-weighted MRI, patients were divided into a high perfusion group (n=121) and a low perfusion group (n=85). The Thrombolysis in Cerebral Infarction scale proposed by Higashida et al. in 2003 (Higashida scale) was used to evaluate the establishment of collateral circulation on the day of admission and 15 days after admission. The National Institutes of Health Stroke Scale (NIHSS) score and the modified Rankin scale assessed the short-term prognosis of patients with cerebral infarction. The Spearman correlation analysis examined the correlation between the rCBV, rCBF, and NIHSS scores, and the modified Rankin scale (mRS).Results: Compared with the patients in the low perfusion group, the rCBV and rCBF in the infarcted area of the patients in the high perfusion group were significantly increased and the rTTP and rMTT were significantly decreased. On day 15 after admission, the collateral circulation rate of the high perfusion group was significantly higher than that of the low perfusion group, and the NIHSS score and the mRS score were significantly lower than those scores of the low perfusion group. Perfusion-weighted MRI indexes, rCBV, and rCBF were negatively correlated with the NIHSS score and Rankin scale.Conclusions: Perfusion-weighted MRI can effectively evaluate the compensatory ability of collateral circulation and the prognosis of patients with acute cerebral infarction.

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Section: Discussionmentioning

confidence: 99%

Evaluation of collateral circulation and short-term prognosis of patients with acute cerebral infarction by perfusion-weighted MRI

Shang¹,

Zhang²,

Li³

et al. 2022

Ann Palliat Med

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“…Furthermore, there is a correlation between MPV levels and adverse outcomes of AIS (Zhang et al, 2017; Zhang, Zhang, et al, 2017). Recently, researchers found that MPV was closely related to the degree of carotid atherosclerosis, and increased MPV was an independent predictor of poor functional outcome in patients with AIS at 3 months (OR: 6.152, 95% CI: 2.385–13.625, p < 0.01) (Xu, He, & Huang, 2020). As far as we know, there are no studies to observe effects of drug intervention on MPV.…”

Section: Discussionmentioning

confidence: 99%

Antiplatelet effect of ginkgo diterpene lactone meglumine injection in acute ischemic stroke: A randomized, double‐blind, placebo‐controlled clinical trial

Chen

Shan

et al. 2023

Phytotherapy Research

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This study was designed to evaluate antiplatelet effect and therapeutic effect of ginkgo diterpene lactone meglumine injection (GDLI) in acute ischemic stroke (AIS) patients. In this randomized, double‐blind, placebo‐controlled trial, we randomly assigned 70 inpatients within 48 hr after the onset of AIS to combination therapy with GDLI and aspirin (GDLI at a dose of 25 mg/d for 14 days plus aspirin at a dose of 100 mg/d for 90 days) or to placebo plus aspirin in a ratio of 1:1. Platelet function, the National Institute of Health Stroke Scale (NIHSS), and the modified Rankin Scale (mRS) were evaluated. A good outcome was defined as NIHSS scores decrease ≥5 or mRS scores decrease ≥2. Results showed that arachidonic acid induced maximum platelet aggregation rate (AA‐MAR) and mean platelet volume (MPV) of the GDLI‐aspirin group were much lower than that of the aspirin group (p = 0.013 and p = 0.034, respectively) after the 14‐day therapy. The combination of GDLI and aspirin was superior to aspirin alone, and had significant impact on the good outcome at day 90 (ORadj 7.21 [95%CI, 1.03–50.68], p = 0.047). In summary, GDLI has antiplatelet effect and can improve the prognosis of AIS patients.

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“…MPV and PC were observed to be independent risk factors for ischemic stroke (Mayda‐Domac et al., 2010 ; Sadeghi et al., 2020 ). Previous studies have suggested that MPV is associated with the prognosis of AIS (Du et al., 2016 ; Greisenegger et al., 2004 ; Wan & Ma, 2017 ; Xu et al., 2020 ; Yang et al., 2019 ; Ye et al., 2020 ), although some studies have reported contradictory findings (Du et al., 2016 ; Mayda‐Domac et al., 2010 ). The studies of PC have mostly been related to cardiology and showed that PC was an independent risk factor for cardiovascular mortality in acute myocardial infarction (AMI) patients (Goliasch et al., 2013 ; Ly et al., 2006 ; Song et al., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of mean platelet volume and platelet count on the prognosis of branch atheromatous disease

Liu,

Wu,

et al. 2024

Brain and Behavior

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ObjectiveThe purpose of this study was to investigate the predictive value of mean platelet volume (MPV) and platelet count (PC) in branch atheromatous disease (BAD).MethodsThis retrospective study included 216 patients with BAD‐stroke within 48 h of symptom onset. These patients were divided into good and poor prognosis groups according to their 3‐month modified Rankin scale scores after discharge. Multiple logistic regression analysis was used to evaluate independent predictors of poor prognosis in BAD‐stroke patients. Receiver‐operating characteristic (ROC) analysis was used to estimate the predictive value of MPV and PC on BAD‐stroke.ResultsOur research showed that a higher MPV (aOR, 2.926; 95% CI, 2.040–4.196; p < .001) and PC (aOR, 1.013; 95% CI, 1.005–1.020; p = .001) were independently associated with poor prognosis after adjustment for confounders. The ROC analysis of MPV for predicting poor prognosis showed that the sensitivity and specificity were 74% and 84.9%, respectively, and that the AUC was .843 (95% CI, .776–.909, p < .001). The optimal cut‐off value was 12.35. The incidence of early neurological deterioration (END) was 24.5% (53 of 163), and 66% of patients in the poor prognosis group had END (33 of 50). Multiple logistic regression analyses showed that elevated MPV and PC were associated with the occurrence of END (p < .05).ConclusionOur results suggested that an elevated MPV and PC may be important in predicting a worse outcome in BAD‐stroke patients. Our study also demonstrated an independent association of MPV and PC with END, which is presumably the main reason for the poor prognosis.

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[Retracted] The Relationship between the Mean Platelet Volume and Carotid Atherosclerosis and Prognosis in Patients with Acute Cerebral Infarction

Cited by 17 publications

References 23 publications

Evaluation of collateral circulation and short-term prognosis of patients with acute cerebral infarction by perfusion-weighted MRI

Evaluation of collateral circulation and short-term prognosis of patients with acute cerebral infarction by perfusion-weighted MRI

Antiplatelet effect of ginkgo diterpene lactone meglumine injection in acute ischemic stroke: A randomized, double‐blind, placebo‐controlled clinical trial

Effect of mean platelet volume and platelet count on the prognosis of branch atheromatous disease

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