RETRACTED: Two Cu(II) coordination polymers: Heterogeneous catalytic Knoevenagel condensation reaction and treatment activity on atherosclerosis via regulating the expression of the COX-2 in vascular endothelial cells

Zhao, Yongchang; Zhang, Yan; Jiang, Deying; Wang, Liang; Sun, Peng

doi:10.1016/j.jinorgbio.2021.111464

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…The Notch signaling pathway is critical in regulating chronic inflammation in atherosclerosis [ 59 ]. Zhao et al found that Cu 2+ coordination polymer inhibited the Notch signaling pathway, significantly reducing the inflammatory events in atherosclerotic segments [ 60 ]. Also, Wang et al found that copper supplements could inhibit atherosclerotic lesions by reducing endothelial cell mortality, lowering cholesterol and phospholipid concentrations in lesion tissue, and minimizing atherosclerotic lesion size [ 3 ].…”

Section: Copper Homeostasis and Cvdmentioning

confidence: 99%

Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

et al. 2023

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Copper is a vital mineral, and an optimal amount of copper is required to support normal physiologic processes in various systems, including the cardiovascular system. Over the past few decades, copper-induced cell death, named cuproptosis, has become increasingly recognized as an important process mediating the pathogenesis and progression of cardiovascular disease (CVD), including atherosclerosis, stroke, ischemia-reperfusion injury, and heart failure. Therefore, an in-depth understanding of the regulatory mechanisms of cuproptosis in CVD may be useful for improving CVD management. Here, we review the relationship between copper homeostasis and cuproptosis-related pathways in CVD, as well as therapeutic strategies addressing copper-induced cell death in CVD.

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Section: Copper Homeostasis and Cvdmentioning

confidence: 99%

Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

et al. 2023

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“…As an illustration, Zhao and colleagues found that Cu 2+ coordination polymers had the capacity to suppress the Notch signaling pathway, which plays a pivotal role in regulating chronic inflammation in individuals with atherosclerosis (AS). Consequently, this intervention led to a notable reduction in inflammatory occurrences within the atherosclerotic region ( Zhao et al, 2021 ). Likewise, Wang and co-researchers observed that copper supplements had the ability to hinder the development of atherosclerotic lesions.…”

Section: Cuproptosis and Copper Homeostasis In Ardmentioning

confidence: 99%

Emerging insights into cuproptosis and copper metabolism: implications for age-related diseases and potential therapeutic strategies

Fan,

Wang,

Zhao

et al. 2024

Front. Aging Neurosci.

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The expanding geriatric population, whose predisposition toward disabling morbidities and age-related diseases (ARD) is well-documented, has become a paramount social issue, exerting an onerous burden on both the healthcare industry and wider society. ARD manifest as the progressive deterioration of bodily tissues and organs, eventually resulting in the failure of these vital components. At present, no efficacious measures exist to hinder the onset of ARD. Copper, an essential trace element, is involved in a wide range of physiological processes across different cell types. In recent research, a novel variant of copper-dependent cell death, termed cuproptosis, has been identified. This mode of cellular demise stands apart from previously recognized types of cell death. Cuproptosis occurs when copper binds with acyl-CoA synthetase in the tricarboxylic acid (TCA) cycle, resulting in protein aggregation and protein toxicity stress, ultimately leading to cell death. In this paper, we provide a concise overview of the current understanding concerning the metabolism of copper, copper-related diseases, the hallmarks of copper toxicity, and the mechanisms that regulate copper toxicity. Additionally, we discuss the implications of cuproptosis mutations in the development of ARD, as well as the potential for targeting cuproptosis as a treatment for ARD.

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“…Nevertheless, in the cases where solvothermal or hydrothermal synthetic methods are involved, the structures of coordination polymers are often influenced by diverse reaction parameters (pH, T , solvent, concentration, etc.) and intrinsic characteristics of ligands and metal nodes. − …”

Section: Introductionmentioning

confidence: 99%

“…As the main class of ligands for preparing CPs/metal–organic frameworks (MOFs), aromatic carboxylic acids containing several COOH groups are especially attractive, given their adaptable deprotonation and charges, tunable coordination behavior, multiple noncovalent interactions, and good thermal stability. ,,, In particular, we have been interested in exploring various carboxylic acids with biphenyl or terphenyl cores for the design of coordination polymers. ,, As a continuation of these studies, − 2′-amino-[1,1′:4′,1″-terphenyl]-3,3″,5,5″-tetracarboxylic acid (H 4 tpta, Scheme ) has been selected in the present work as a still little studied amino-functionalized triphenyl-tercarboxylate building block. This ligand has been investigated as a linker for constructing CPs/MOFs via hydrothermal synthesis using water as a green reaction medium.…”

Section: Introductionmentioning

confidence: 99%

Coordination Polymers from an Amino-Functionalized Terphenyl-Tetracarboxylate Linker: Structural Multiplicity and Catalytic Properties

Fan,

Wang,

et al. 2023

Inorg. Chem.

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An amino-functionalized terphenyl-tetracarboxylic acid, 2′-amino-[1,1′:4′,1″-terphenyl]-3,3″,5,5″-tetracarboxylic acid (H 4 tpta), was used as an adaptable linker to synthesize, under hydrothermal conditions, eight coordination polymers (CPs). The obtained products were formulated as [Co(μ 6 -H, wherein 2,2′-bipyridine (2,2′-bipy), 4,4′bipyridine (4,4′-bipy), 1,10-phenanthroline (phen), or 2,2′-biimidazole (H 2 biim) are present as additional stabilizing ligands. The structural types of 1−8 vary from onedimensional (1D) (2, 5) and two-dimensional (2D) (3, 4, 6) CPs to three-dimensional (3D) metal−organic frameworks (MOFs) (1, 7, and 8) with a diversity of topologies. The products 1−8 were investigated as catalysts in the Knoevenagel condensation involving aldehydes and active methylene derivatives (malononitrile, ethyl cyanoacetate, or tertbutyl cyanoacetate), leading to high condensation product yields (up to 99%) under optimized conditions. Various reaction conditions, substrate scope, and catalyst recycling were investigated. This work broadens the application of H 4 tpta as a versatile tetracarboxylate linker for the generation of diverse CPs/MOFs.

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RETRACTED: Two Cu(II) coordination polymers: Heterogeneous catalytic Knoevenagel condensation reaction and treatment activity on atherosclerosis via regulating the expression of the COX-2 in vascular endothelial cells

Cited by 3 publications

References 20 publications

Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

Copper homeostasis and copper-induced cell death in the pathogenesis of cardiovascular disease and therapeutic strategies

Emerging insights into cuproptosis and copper metabolism: implications for age-related diseases and potential therapeutic strategies

Coordination Polymers from an Amino-Functionalized Terphenyl-Tetracarboxylate Linker: Structural Multiplicity and Catalytic Properties

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