Retraction note: Anti-inflammatory and protective investigations on the effects of Theranekron® “an alcoholic extract of the Tarantula cubensis” on wound healing of peritoneal in the rat: an in vivo comparative study

Adib-Hashemi, Farajollah; Farahmand, Farshad; Hesari, Shamim Fattah; Rezakhaniha, Bijan; Fallah, Ehsan; Fayyaz, Amir Farshid; Dadpay, Masoomeh

doi:10.1186/s13000-016-0575-2

Cited by 5 publications

(2 citation statements)

References 5 publications

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“…It is stated that TC application as an additional treatment in the treatment of tongue erosion in cats completely passes erosion and re-epithelialization is observed in the upper lip ulcer 7 . It has been stated that, in the endometriasis model, TC application prevented relapses 8 accelerated wound healing after laparotomy 9 and may be partially prevent oxidative stress after exposure to a atoxin in rats 10 .…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Investigation of regenerative effects of Theranekron ® and Misoprostol after partial hepatectomy in rats

Yılmaz

Kanat

Yıldız

et al. 2022

Preprint

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Background/Aims: In the present study we were aimed to investigate/compare regenerative effects of Theranekron® (TC) and Misoprostol (MS) after Partial Hepatectomy (PH) in rats. Material and Methods: This study was conducted in 38 rats, they were divided in to 5 groups and 14 days study periot. Results, and Conclusions: When considering biochemical and histopathological results; we were seen that before and after PH 7 days duration and used dozes of both drugs was not sufficient and also higher dozes and at least 10 days periot may be necessary. Althought some literatures were reported about positive effects of TC and MS on epithelial growing, we have not seen that they have not any positive effect on liver regeneration. For future research -at higher dozes and durations- may be found effective.

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Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Investigation of regenerative effects of Theranekron ® and Misoprostol after partial hepatectomy in rats

Yılmaz

Kanat

Yıldız

et al. 2022

Preprint

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“…It is an alcoholic extract produced by processing the whole spider known as Tarantula cubensis and diluting in 60% alcohol. There are many studies carried out with theranekron to present its beneficial effect in the veterinary medicine area such as wound healing [22], anti-inflammatory [23], and necrotizing action [4]. In addition to these studies, antibacterial effect of theranekron was evaluated, but they could not find significant antibacterial property of the venom [24].…”

Section: Discussionmentioning

confidence: 99%

Alcoholic extract of Tarantula cubensis (Theranekron®) induce autophagy on gastric cancer cells

Yenigün¹,

Azzawri²,

Acar³

et al. 2021

j-ebr

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To evaluate the effects of theranekron in respect of autophagy on gastric cancer that is the fifth leading cancer type worldwide. Metods: In the present study, metastatic AGS and non-metastatic MKN-45 human gastric cell lines were used together with HEK-293 non-cancer cells as controls. Cytotoxic effect of theranekron besides appropriate treatment time was investigated through cell proliferation by using Cell Proliferation assay Kit (MTT) using different concentrations of the drug. The autophagic effect of the drug was determined using the LC3-GFP translocation assay and western blot analysis. All experiments were performed also using the ethanol since Tarantula cubensis spider was processed and diluted in 60% alcohol to generate as a drug. Results: MTT assay results demonstrated that the half maximal inhibitory concentration of theranekron was ~100 μM, its effect was found to be significant at 6 hrs, and theranekron decreased the cell viability in all cell lines without specificity in respect to the increasing concentrations. Additionally, a significantly increased GFP accumulation was detected in the autophagosomes of the cells treated with theranekron compared to nontreated cells, indicating the presence of autophagy. Conclusion: These findings were confirmed by LC3-I to LC3-II conversion with the western blot analysis. The data of ethanol experiments; however, demonstrated that ethanol also induced a cytotoxic effect and autophagic cell death. Our results suggested that theranekron results in cell death and stimulate autophagy process, but it is not specific for cancer cells since it represented similar results on non-cancer control cells. Moreover, the effect of theranekron on cell death might mostly occur through alcohol in which it is extracted.

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Evaluation of Anticancer and Antimicrobial Potentials of Tarantula cubensis Venom (Theranekron® D6)

Gökşen Tosun,

Kaplan,

Özgür

2024

Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi

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Tarantula cubensis venom (Theranekron®D6) is widely used in veterinary medicine as a drug with anti-tumor, wound healing, anti-inflammatory, antiphlogistic properties. The purpose of the study was to explore Theranekron®D6 (TD6)'s antibacterial activity and its impact on apoptotic cell death in human colon and liver cancer cell lines. TD6 showed a dose and time dependent cytotoxic effect at 12h and 24h in HT-29 and HUH-7 cancer cell lines. The IC50 values of TD6 were calculated as 12.18 µg/mL and 25.10 µg/mL in HT-29 and HUH-7 cell lines at 24h, respectively. TD6 induced apoptosis in HT-29 and HUH-7 cell lines. In these cells exposed to TD6, while the BAX/BCL-2 ratio and CASP-3 mRNA level increased, the HSP90 mRNA and protein level decreased. Also, TD6 exhibited antimicrobial activities against Pseudomonas aeruginosa, Enterococcus faecalis, Klebsiella pneumonia, Staphylococcus aureus, Candida albicans and Candida utilis. Obtained results demonstrated that TD6 has great potentials as alternative therapeutic for cancer and infectious diseases as apoptosis inducer and antimicrobial agent.

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Retraction note: Anti-inflammatory and protective investigations on the effects of Theranekron® “an alcoholic extract of the Tarantula cubensis” on wound healing of peritoneal in the rat: an in vivo comparative study

Cited by 5 publications

References 5 publications

WITHDRAWN: Investigation of regenerative effects of Theranekron ® and Misoprostol after partial hepatectomy in rats

WITHDRAWN: Investigation of regenerative effects of Theranekron ® and Misoprostol after partial hepatectomy in rats

Alcoholic extract of Tarantula cubensis (Theranekron®) induce autophagy on gastric cancer cells

Evaluation of Anticancer and Antimicrobial Potentials of Tarantula cubensis Venom (Theranekron® D6)

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