Retraction notice to “Isolation and characterization of a new steroid derivative as a powerful antioxidant from Cleome Arabica in screening the in vitro antioxidant capacity of eighteen Algerian medicinal plants” [Food and Chem. Toxicol. 48 10 October 2010 2599–2606]

Isolation and structure elucidation of bioactive compounds from the roots of the Tunisian Ononis angustissima L.

“…Results are expressed as means ± standard deviation from two separated experiments with triplicates. *** p <0.0001 compared to 10 lM Ab(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) .…”

“…We performed in consequence the neuroprotective assays for each compounds with the appropriate concentration(s), the one(s) that did not affect cell viability. Firstable, we noted that Ab [25][26][27][28][29][30][31][32][33][34][35] induced approximately 60% of cell death (Fig. 3).…”

“…However, it has been found that its aerial parts are a good source of antioxidant polyphenols and flavonoids. 26,27 The biological importance of some Ononis species encouraged us to undertake a phytochemical study of the roots of O. angustissima previously not chemically studied. In this context, we described here the bio-guided isolation and structure determination of a novel isoflavone glycoside 1 together with nine phenolic compounds 2-10 from O. angustissima extracts.…”

“…Compound 9 at 30 lM slightly but significantly (about 5%) attenuated the cytotoxic effects of Ab [25][26][27][28][29][30][31][32][33][34][35] , and compound 10 at 30 lM significantly increased the cellular viability of 18%. Treatments with concentration of 75 lM did not prevent the Ab 25-35 cytotoxicity in the case of compound 4, whereas in the case of compounds 9 and 10, they led to a notable increase of cell viability of 15% and 30%, respectively.…”

“…In addition, the neuroprotective activity of six isolated molecules (4-7, 9, 10) were evaluated. Following the exposure of PC12 cells to Ab [25][26][27][28][29][30][31][32][33][34][35] , compounds 9 and 10 triggered a significant increase of cell viability and in a dose dependant manner.…”