Retrograde and oscillatory shear increase across the menopause transition

Somani, Yasina; Moore, David; Kim, Danielle Jin-Kwang; Gonzales, Joaquin U.; Barlow, Matthew A.; Elavsky, Steriani; Proctor, David N.

doi:10.14814/phy2.13965

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…Low mean shear stress may facilitate early atheroma by reducing mass transport from the arterial wall, which is one of the primary reasons exercise, an intermittent episodic high shear stress stimulus, is vasoprotective in nature (Caro et al 1971). Furthermore, OSS is enhanced with ageing (Casey et al 2012), pre-eclampsia (Scholten et al 2014), menopause (Somani et al 2019) and anabolic steroid use (de Souza et al 2019). To examine the causality of OSS it can be experimentally induced in otherwise healthy upstream arteries by inflating a pneumatic cuff on the forearm to a moderate pressure (ß50-75 mmHg; Thijssen et al 2009;Tremblay et al 2019a).…”

Section: Shear Stressmentioning

confidence: 99%

The impact of hypoxaemia on vascular function in lowlanders and high altitude indigenous populations

Tymko

Tremblay

Bailey

et al. 2019

The Journal of Physiology

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Exposure to hypoxia elicits widespread physiological responses that are critical for successful acclimatization; however, these responses may induce apparent maladaptive consequences. For example, recent studies conducted in both the laboratory and the field (e.g. at high altitude) have demonstrated that endothelial function is reduced in hypoxia. Herein, we review the several proposed mechanism(s) pertaining to the observed reduction in endothelial function in hypoxia including: (i) changes in blood flow patterns (i.e. shear stress), (ii) increased inflammation and production of reactive oxygen species (i.e. oxidative stress), (iii) heightened sympathetic nerve activity, and (iv) increased red blood cell concentration and mass leading to elevated nitric oxide scavenging. Although some of these mechanism(s) have been examined in lowlanders, less in known about endothelial function in indigenous populations that have chronically adapted to environmental hypoxia for millennia (e.g. the Peruvian, Tibetan and Ethiopian highlanders). There is some evidence indicating that healthy Tibetan and Peruvian (i.e. Andean) highlanders have preserved endothelial function at high altitude, but less is known about the Ethiopian highlanders. However, Andean highlanders suffering from chronic mountain sickness, which is characterized by an excessive production of red blood cells, have markedly reduced endothelial function. This review will provide a framework and mechanistic model for vascular endothelial adaptation to hypoxia in lowlanders and highlanders. Elucidating the pathways responsible for vascular adaption/maladaptation to hypoxia has potential clinical implications for disease featuring low oxygen delivery (e.g. heart failure, pulmonary disease). In addition, a greater understanding of vascular function at high altitude will clinically benefit the global estimated 85 million high altitude residents.

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Section: Shear Stressmentioning

confidence: 99%

The impact of hypoxaemia on vascular function in lowlanders and high altitude indigenous populations

Tymko

Tremblay

Bailey

et al. 2019

The Journal of Physiology

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“…Menopozun ortalama yaşı 51 yaştır. Diğer taraftan kemoterapi, histerektomi, prematüre yumurtalık sendromu gibi durumlar erken menopoza (<45 yaş) yol açabilir [1,2].…”

Section: Introductionunclassified

The Effect of Nonpharmacological Methods on Sleep Quality in Menopausal Period: A Systematic Review of Randomized Controlled Studies Abstract

ARAR

Erbi̇l

2022

Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi

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Objective: It is aimed to review randomized controlled studies to improve sleep quality in menopause and to systematically examine the findings obtained from these studies.Method: In this study, which is a systematic review, the PRISMA protocol, which is a guide in writing the systematic review or meta-analysis research report, was used. In the study, Scopus, PubMed, Web of Science, Cochrane and Türk Medline databases were searched between December 2020 and March 2021. The keywords "menopause, sleep quality, randomized controlled trial" in Turkish and "menopause, sleep quality, randomized controlled trial" in English were used in the search. Randomized controlled studies, published in Turkish or English, published between January 2015 and December 2020, which address the effect of non-pharmacological methods on sleep quality in the menopausal period, with full text available, were included in this systematic reviewResults: A total of 365 records were reached in the study and 13 randomized controlled studies were included as a result of the analysis. From non-pharmacological studies to improve sleep quality in menopause; While acupuncture, acupressure, telephone-based cognitive behavioral therapy, pedometer walking, bitter orange or lavender flower powder, pilates-based exercises, mindfulness meditation training, jujube seed capsule, foot bath significantly improved sleep quality in menopause, the effectiveness of chamomile extract and fennel was found to be uncertain.Conclusion: It was concluded that non-pharmacological interventions are effective in increasing sleep quality in menopause, but objective sleep measurement techniques should be applied for future non-pharmacological studies explaining the medium and long-term effects.

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Effects of the Follicular Menstrual Phase on Forearm Vascular Conductance in Abdominal Obese Premenopausal Women During Graded Handgrip Exercise

2022

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Purpose Previous studies have reported a sympatholytic action of estrogen on the vasculature in response to increased sympathetic outflow, an effect most notable during exercise, providing for necessary increases in blood flow to working muscle. In contrast, elevated concentrations of progesterone can inhibit this action of estrogen, impairing increases in blood flow. We hypothesize that the peak concentration of estrogen during the proliferative portion of the follicular phase of the menstrual cycle in female humans will increase vascular conductance during exercise when the effects of progesterone are negligible. In addition, we hypothesize that overweight abdominally obese females will have an attenuated conductance response to dynamic exercise during the same menstrual phase. Methods Participants engaged in graded forearm exercise using an isotonic handgrip dynometer with sequential increases in resistance at a cadence of 30 contractions/minute until task failure. They performed exercise at time points of the menstrual cycle corresponding to low concentrations of both sex hormones and elevated estrogen, while progesterone remained low. Blood flow and vascular conductance were measured using Doppler ultrasound. Results This revealed a trend that abdominal obese women during a phase of low estrogen had a lower overall blood flow and vascular conductance response than healthy controls at matching resistance stages during rest and exercise. This group difference was attenuated during the proliferative phase with elevated circulating estrogen. There is not a statistically significant interaction between Ovarian Phase and Weight group (P = 0.778). Conclusion The results indicate that overweight women are at a disadvantage during exercise in increasing blood flow to working muscles, which can be detrimental to overall fitness improvement during the early and potentially late follicular phase of the menstrual cycle.

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Retrograde and oscillatory shear increase across the menopause transition

Cited by 6 publications

References 37 publications

The impact of hypoxaemia on vascular function in lowlanders and high altitude indigenous populations

The impact of hypoxaemia on vascular function in lowlanders and high altitude indigenous populations

The Effect of Nonpharmacological Methods on Sleep Quality in Menopausal Period: A Systematic Review of Randomized Controlled Studies Abstract

Effects of the Follicular Menstrual Phase on Forearm Vascular Conductance in Abdominal Obese Premenopausal Women During Graded Handgrip Exercise

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