Retrograde gastric electrical stimulation suppresses calorie intake in obese subjects

Du, Shiyu; Long, Fang; Yao, Shukun; Chen, Jiande D.Z.

doi:10.1002/oby.20664

Cited by 16 publications

(8 citation statements)

References 19 publications

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“…Two studies, one from TANTALUS ® [39] and the other from gastric pacing [40] , found lower ghrelin levels after device activation. However, three studies, two from IGS [41,42] and another TANTALUS ® [43] study, found no statistically significant changes in ghrelin levels. Another interesting find was that 4 studies, including 2 RGES [41,44] studies and 2 gastric pacing [42,45] studies, demonstrated delayed gastric emptying whereas one TANTALUS ® study demonstrated the opposite effect.…”

Section: Co-morbiditiesmentioning

confidence: 95%

Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives

Cha

Marescaux

Diana

2014

WJGE

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AIM:To evaluate the current state-of-the-art of gastric electrical stimulation to treat obesity. METHODS:Systematic reviews of all studies have been conducted to evaluate the effect of different types of gastric electrical stimulation (GES) on obesity. RESULTS:Thirty-one studies consisting of a total of 33 different trials were included in the systematic review for data analysis. Weight loss was achieved in most studies, especially during the first 12 mo, but only very few studies had a follow-up period longer than 1 year. Among those that had a longer follow-up period, many were from the Transcend ® (Implantable Gastric Stimulation) device group and maintained significant weight loss. Other significant results included changes in appetite/satiety, gastric emptying rate, blood pressure and neurohormone levels or biochemical markers such as ghrelin or HbA1c respectively. CONCLUSION:GES holds great promises to be an effective obesity treatment. However, stronger evidence is required through more studies with a standardized way of carrying out trials and reporting outcomes, to determine the long-term effect of GES on obesity. Key words: Gastric electrical stimulation; TANTALUS ® system; Transcend ® implantable gastric stimulator; Retrograde gastric electrical stimulation; Gastric vagal nerve stimulation; Gastric pacing; EMPOWER trial; Dual-lead implantable gastric electrical stimulation trial; Laparoscopic obesity stimulation survey; Screened health assessment and pacer evaluation Core tip: Obesity is a major issue in many countries. Current medical treatments do not last long enough and while surgical interventions are more effective, they imply a higher risk of complications. This review contains the most up-to-date information on gastric electrical stimulation, which has shown to be a less invasive and potentially effective treatment option for the treatment of obesity.Cha R, Marescaux J, Diana M. Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives. World J Gastrointest Endosc 2014; 6(9): 419-431 Available from:

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Section: Co-morbiditiesmentioning

confidence: 95%

Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives

Cha

Marescaux

Diana

2014

WJGE

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“…65 The mechanisms of action include changes in gastric emptying or gastric accommodation and induction of satiety. 66,67 …”

Section: Novel Devices Proposed In Obesity Treatment and Their Potentmentioning

confidence: 99%

Gastrointestinal traits: individualizing therapy for obesity with drugs and devices

Camilleri

Acosta

2016

Gastrointestinal Endoscopy

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Objectives The objectives were to review the discrepancy between numbers of people requiring weight loss treatment and results, and to assess the potential effects of pharmacological treatments (recently approved for obesity) and endoscopically deployed devices on quantitative gastrointestinal traits in development for obesity treatment. Methods We conducted a review of relevant literature to achieve our objectives. Results The 2013 guidelines increased the number of adults recommended for weight loss treatment by 20.9% (116.0 million to 140.2 million). There is an imbalance between efficacy and costs of commercial weight loss programs and drug therapy (average weight loss ~5 kg). The number of bariatric procedures performed in the United States has doubled in the past decade. The efficacy of bariatric surgery is attributed to reduction in the volume of the stomach, nutrient malabsorption with some types of surgery, increased postprandial incretin responses, and activation of farnesoid X receptor mechanisms. These gastrointestinal and behavioral traits identify sub-phenotypes of obesity based on recent research. Conclusions The mechanisms or traits targeted by drug and device treatments include centrally mediated alterations of appetite or satiation, diversion of nutrients, and alteration of stomach capacity, gastric emptying, or incretin hormones. Future treatment may be individualized based on quantitative gastrointestinal and behavioral traits measured in obese patients.

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“…Acute retrograde gastric electrical stimulation is a process in which electrodes are endoscopically placed into the stomach to simulate satiety [36]. One study (n ¼ 16) found a significantly reduced caloric intake among patients with electrodes placed in their stomach, but the study did not examine weight loss as an outcome [37].…”

Section: Electrical Stimulation (Fda Status: Not Approved)mentioning

confidence: 99%

Endoscopic treatments of obesity: a comprehensive review

Neylan

Dempsey

Tewksbury

et al. 2016

Surgery for Obesity and Related Diseases

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Retrograde gastric electrical stimulation suppresses calorie intake in obese subjects

Cited by 16 publications

References 19 publications

Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives

Updates on gastric electrical stimulation to treat obesity: Systematic review and future perspectives

Gastrointestinal traits: individualizing therapy for obesity with drugs and devices

Endoscopic treatments of obesity: a comprehensive review

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