2007
DOI: 10.2741/2355
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Retromer and sorting nexins in development

Abstract: Trafficking and signaling processes involve common molecular components. The machinery that controls intracellular trafficking is vital in ensuring that signaling mechanisms take place correctly. An illustrative example of this relationship is the sustained signaling of endocytosed membrane receptors, such as receptor Tyr kinases and G-protein coupled receptors, after ligand-induced activation. An intriguing role in controlling the fate of these and other receptors at the endosome has been attributed to member… Show more

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Cited by 30 publications
(31 citation statements)
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“…The mammalian sorting nexin family currently includes 31 members [50]. In general, sorting nexins are believed to play a role in subcellular membrane and protein trafficking [52,53]. Several sorting nexins, including SNX1 and SNX2, have been defined as components of a mammalian retromer complex functioning in the retrieval of cargos from the endosomal system to the Golgi.…”
Section: Discussionmentioning
confidence: 99%
“…The mammalian sorting nexin family currently includes 31 members [50]. In general, sorting nexins are believed to play a role in subcellular membrane and protein trafficking [52,53]. Several sorting nexins, including SNX1 and SNX2, have been defined as components of a mammalian retromer complex functioning in the retrieval of cargos from the endosomal system to the Golgi.…”
Section: Discussionmentioning
confidence: 99%
“…The equivalent proteins are required in mammalian cells for endosome to Golgi retrograde recycling of the mannose 6-phosphate receptor, another type of hydrolase receptor that carries newly produced lysosomal enzymes from the Golgi to endosomes and that must then recycle back to the Golgi. The C. elegans retromer consists of the VPS-35, VPS-26 and VPS-29 cargo recognition trimer, and the SNX-1/SNX-6 (Vps5/Vps17) obligate heterodimer (Verges, 2007; PMID 17485342). Recent work also links sorting nexin SNX-3 to this pathway in worms (Harterink et al, 2011; PMID 21725319).…”
Section: Endocytosis: Screens and Assaysmentioning
confidence: 99%
“…SNX-1, SNX-6, and their human homologs are components of the retromer complex that mediates endosome-to-Golgi retrieval of transmembrane receptors and other trafficking-related proteins in worms and humans (Coudreuse et al 2006;Verges 2007;Pan et al 2008;Yang et al 2008;Shi et al 2009). The engulfment receptor CED-1 has been reported to be recycled from the phagosome back to the plasma membrane by the retromer complex.…”
Section: Formation and Maturation Of Phagosomesmentioning
confidence: 99%