Retroperitoneal Accessory Spleen Presented As Metastatic Suprarenal Tumour- A Diagnostic Dilemma

Porwal, Rekha; Singh, Amit; Jain, Pritesh

doi:10.7860/jcdr/2015/13229.6120

Cited by 7 publications

(13 citation statements)

References 3 publications

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“…It should also be emphasized that in humans ectopic splenic tissue also has a different architecture compared to a normal spleen, with plenty of red pulp and quite a small area of white pulp [ 13 , 14 ]. Accessory spleens may represent a differential diagnostic challenge, and several cases of an accessory spleen being mistaken for an adrenal tumor have been published [ 15 , 16 , 17 ]. The very rare accessory spleens mimicking a retroperitoneal tumor on the right side represent an even more challenging situation [ 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background

et al. 2020

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Foci of splenic tissue separated from the spleen can occur as a congenital anomaly. Isolated nodules of splenic tissue are called accessory spleens or spleniculli. However, nodules of splenic tissue can merge with other organs during embryonic development, in which case we speak of spleno-visceral fusions: most often, they merge with the tail of the pancreas (thus forming spleno-pancreatic fusion or an intrapancreatic accessory spleen), with the reproductive gland (i.e., spleno-gonadal fusion), or with the kidney (i.e., spleno-renal fusion). Our case report describes the fusion of heterotopic splenic tissue with the right adrenal gland, which was misinterpreted as a metastasis of a renal cell carcinoma. To the best of our knowledge, this is the first reported case of spleno-adrenal fusion. Spleno-visceral fusions usually represent asymptomatic conditions; their main clinical significance lies in the confusion they cause and its misinterpretation as tumors of other organs. We believe that the cause of retroperitoneal spleno-visceral fusions is the anomalous migration of splenic cells along the dorsal mesentery to the urogenital ridge, together with primitive germ cells, at the end of the fifth week and during the sixth week of embryonic age. This theory explains the possible origin of spleno-visceral fusions, their different frequency of occurrence, and the predominance of findings on the left side.

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Section: Discussionmentioning

confidence: 99%

Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background

et al. 2020

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“…They are present in 10%-30% of the population and are typically located adjacent to the spleen (common sites include the splenic hilum, adjacent to the pancreatic tail and along the splenic artery) although various ectopic locations have been reported. [3][4][5] Most patients with splenosis or accessory spleens are asymptomatic, and the splenic abnormality is found incidentally on imaging performed for another reason. When symptoms do occur, they are generally a result of the splenic tissue causing blockage of another organ (e.g., bowel obstruction or hydronephrosis) or from bleeding or infarction of the splenic tissue.…”

Section: Discussionmentioning

confidence: 99%

Benign splenic regrowth mistaken as recurrent renal cell carcinoma

McAlpine

Breau

2019

CMAJ

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“…Mihmanli et al [ 5 ] described a case of ovarian carcinoma metastatic to a mass located in the transverse mesocolon which resulted to be an accessory spleen containing metastatic ovarian carcinoma. The second case, reported by Porwal et al [ 6 ], was a retroperitoneal, suprarenal accessory spleen infiltrated by metastatic transitional cell carcinoma of the kidney.…”

Section: Discussionmentioning

confidence: 99%

“…Metastases from solid tumors to accessory spleens are extremely rare. To our knowledge only two such cases were reported previously [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

Groisman

2016

Case Reports in Pathology

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Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections.

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Retroperitoneal Accessory Spleen Presented As Metastatic Suprarenal Tumour- A Diagnostic Dilemma

Cited by 7 publications

References 3 publications

Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background

Spleno-adrenal fusion mimicking an adrenal metastasis of a renal cell carcinoma: A case report and embryological background

Benign splenic regrowth mistaken as recurrent renal cell carcinoma

Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

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