Retroperitoneal Sarcoma (RPS) Target Volume and Organ at Risk (OAR) Contour Delineation Agreement Among RTOG Sarcoma Radiation Oncologists

Baldini, Elizabeth H.; Bosch, Walter; Abrams, Ross A.; Roberge, David; Olsen, Jeffrey R.; Haas, Rick L.; Catton, Charles; Indelicato, Daniel J.; DeLaney, Thomas F.; Wang, D.

doi:10.1016/j.ijrobp.2014.05.546

Cited by 2 publications

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“…For example, a group of 12 radiation oncology sarcoma experts were asked to contour a high-risk boost volume for 2 patients with RPS. Agreement of the contoured high-risk volumes was only moderate (66). A second study whereby seven radiation and surgical oncologist teams contoured high risk volumes showed similar moderate or substantial contour agreement (67).…”

Section: Boost Dose To Area Of High-risk Margins With Ebrt or Intraopmentioning

confidence: 91%

“…A group of 12 sarcoma experts contoured individual segments of small bowel and colon as well as a bowel bag for 2 cases of RPS. The overall delineation agreement was quite good for both approaches, although agreement for duodenum contours was only fair (66). The RPS consensus panel acknowledged that either approach to bowel contouring is acceptable.…”

Section: Delineation Of Radiation Treatment Volumes (Gtv Igtv Ctv mentioning

confidence: 96%

See 1 more Smart Citation

Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel

Baldini

Wang

Haas

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

107

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Section: Boost Dose To Area Of High-risk Margins With Ebrt or Intraopmentioning

confidence: 91%

Section: Delineation Of Radiation Treatment Volumes (Gtv Igtv Ctv mentioning

confidence: 96%

Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel

Baldini

Wang

Haas

et al. 2015

International Journal of Radiation Oncology*Biology*Physics

107

View full text Add to dashboard Cite

“…14 In our prior report, where only radiation oncologists contoured volumes, contour agreement for HR CTV Boost was only moderate. 16 This prompted the current investigation to better define the high-risk boost volume. Interestingly, in this project where radiation oncologists contoured HR GTV Boost volumes together with surgeons, contour agreement between teams was similar to our prior study.…”

Section: Discussionmentioning

confidence: 99%

“…15 In a subsequent project, 12 sarcoma radiation oncologists contoured preoperative target volumes (gross tumor volume: GTV, clinical target volume: CTV, and HR CTV) for two RPS cases to assess levels of contouring agreement and determine whether the guidelines were practical, feasible, and reproducible. 16 GTV and CTV were contoured with a high level of agreement. However, agreement for HR CTV was only moderate.…”

mentioning

confidence: 99%

Retroperitoneal Sarcoma (RPS) High Risk Gross Tumor Volume Boost (HR GTV Boost) Contour Delineation Agreement Among NRG Sarcoma Radiation and Surgical Oncologists

et al. 2015

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Purpose-Curative intent management of retroperitoneal sarcoma (RPS) requires gross total resection. Preoperative radiotherapy (RT) often is used as an adjuvant to surgery, but recurrence rates remain high. To enhance RT efficacy with acceptable tolerance, there is interest in delivering "boost doses" of RT to high-risk areas of gross tumor volume (HR GTV) judged to be at risk for Thomas F. DeLaney and Dian Wang are co-senior authors.Presented in part at the annual meeting of Connective Tissue Oncology Society (CTOS); Berlin, 2014. DISCLOSURES Dr. Bosch has grants from U.S. National Cancer Institute. HHS Public Access Author Manuscript Author ManuscriptAuthor ManuscriptAuthor Manuscript positive resection margins. We sought to evaluate variability in HR GTV boost target volume delineation among collaborating sarcoma radiation and surgical oncologist teams.Methods-Radiation planning CT scans for three cases of RPS were distributed to seven paired radiation and surgical oncologist teams at six institutions. Teams contoured HR GTV boost volumes for each case. Analysis of contour agreement was performed using the simultaneous truth and performance level estimation (STAPLE) algorithm and kappa statistics.Results-HRGTV boost volume contour agreement between the seven teams was "substantial" or "moderate" for all cases. Agreement was best on the torso wall posteriorly (abutting posterior chest abdominal wall) and medially (abutting ipsilateral para-vertebral space and great vessels). Contours varied more significantly abutting visceral organs due to differing surgical opinions regarding planned partial organ resection.Conclusions-Agreement of RPS HRGTV boost volumes between sarcoma radiation and surgical oncologist teams was substantial to moderate. Differences were most striking in regions abutting visceral organs, highlighting the importance of collaboration between the radiation and surgical oncologist for "individualized" target delineation on the basis of areas deemed at risk and planned resection.Surgery is the only potentially curative treatment for localized retroperitoneal sarcoma (RPS). However, local recurrence rates following resection alone are very high, ranging from 50 to 80 %. 1 Randomized trials have clearly demonstrated that adjuvant radiation therapy (RT) is associated with improved local control for extremity soft-tissue sarcoma (STS). [2][3][4] Extrapolating from these data, preoperative RT may be similarly beneficial for RPS. To date, retrospective studies assessing benefits of RT for RPS have shown mixed results. [5][6][7][8][9][10][11][12] The ongoing European Organization for Research and Treatment of Cancer (EORTC) randomized, controlled trial assessing surgery alone compared with preoperative RT followed by surgery will hopefully provide robust data to address this important question. 13 In the absence of conclusive data, many RPS multidisciplinary teams empirically utilize preoperative RT as part of initial treatment or at the time of resectable local recurrence. Because attaining ne...

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Retroperitoneal Sarcoma (RPS) Target Volume and Organ at Risk (OAR) Contour Delineation Agreement Among RTOG Sarcoma Radiation Oncologists

Abstract: 2016-12-23T18:47:23

Cited by 2 publications

References 0 publications

Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel

Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel

Retroperitoneal Sarcoma (RPS) High Risk Gross Tumor Volume Boost (HR GTV Boost) Contour Delineation Agreement Among NRG Sarcoma Radiation and Surgical Oncologists

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