Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China

Zheng, Yonggui; Bao, Lei; Ning, Yan; Lu, Xin; Hua, Keqin; Yi, Xiaofang

doi:10.1016/j.ijgo.2014.10.027

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Histological findings from a PSTT are specific, but it is difficult to distinguish the benign or malignant characteristics of a PSTT. A high mitotic rate of more than 5/10 high-power field and substantial hemorrhaging and necrosis within the tumor has been suggested malignancy and the essential pathologic predictor for disease recurrence [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea

et al. 2018

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ObjectivePlacental site trophoblastic tumor (PSTT) is the rarest form of gestational trophoblastic disease (GTD) and the optimum management is still controversial. In this study, we analyzed the clinical features, treatment, and outcomes of 6 consecutive patients with PSTT treated in our institution.MethodsThe electronic medical record database of Samsung Medical Center was screened to identify patients with PSTT from 1994 to 2017. Medical records for the details of each patient's clinical features and treatment were extracted and reviewed. This study was approved Institutional Review Board of our hospital.ResultsA total of 418 cases of GTD, 6 (1.4%) patients with PSTT were identified. The median age of the patients was 31 years. The antecedent pregnancy was term in all 5 cases with available antecedent pregnancy information and the median interval from pregnancy to diagnosis of PSTT was 8 months. The median titer of serum beta human chorionic gonadotropin (β-hCG) at diagnosis was 190.9 mIU/mL. Five (83.3%) patients presented with irregular vaginal bleeding and one (16.7%) had amenorrhea. All patients had disease confined to the uterus without metastasis at diagnosis and were successfully treated by hysterectomy alone. All of them were alive without disease during the follow-up period.ConclusionIn this study, we observed low level serum β-hCG titer and irregular vaginal bleeding with varying interval after antecedent term pregnancy were most common presenting features of PSTT. In addition, we demonstrated hysterectomy alone was successful for the treatment of stage I disease of PSTT.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea

et al. 2018

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Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside

Santoro

Laganà

Micali

et al. 2016

Arch Gynecol Obstet

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The lack of uniformity in data collection seen so far has limited full knowledge of PSTT. For this reason, we suggest a model (PSTT model) that collects and unifies PSTT evidence as this would be useful to identify worldwide precise prognostic factors, which are still lacking. When PSTT is diagnosed, the proper procedure seems to be total hysterectomy, with sampling of pelvic lymph nodes and ovarian conservation. For advanced-stage diseases, (stage III and IV) a combination of surgery and polychemotherapy is suggested.

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A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors

et al. 2019

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Placental site trophoblastic tumor (PSTT) is a rare type of gestational trophoblastic disease originating from the intermediate trophoblast. Compared with hydatidiform mole, invasive hydatidiform mole and choriocarcinoma, the diagnosis of PSTT is more complicated and lacks specific and sensitive tumor markers. Most PSTT patients demonstrate malignant potential, and the primary treatment of PSTT is hysterectomy. However, metastasis occasionally occurs and even causes death in a small number of PSTT patients. Most PSTT patients are young women hence fertility preservation is an important consideration. The major obstacle for PSTT patient prognosis is chemotherapy resistance. However, the current understanding of the pathogenesis of PSTT and clinical treatment remains elusive. In this review, we summarized the research progress of PSTT in recent years from three aspects: mechanism, clinical presentation, and treatment and prognosis. Well-conducted multi-center studies with sufficient sample sizes are of great importance to better examine the pathological progress and evaluate the prognosis of PSTT patients, so as to develop prevention and early detection programs, as well as novel treatment strategies, and finally improve prognosis for PSTT patients.

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Retrospective analysis of the clinicopathologic and prognostic characteristics of stage I placental site trophoblastic tumor in China

Abstract: Pretreatment β-hCG concentration and mitotic index might be predictors of recurrence among patients with PSTT. Fertility-preserving therapy might be practical in some patients.

Cited by 4 publications

References 16 publications

Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea

Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea

Historical, morphological and clinical overview of placental site trophoblastic tumors: from bench to bedside

A Review on the Pathogenesis and Clinical Management of Placental Site Trophoblastic Tumors

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