Retrospective Evaluation of 35 Pediatric Tuberculosis Cases Proven by Histopathological and/or Microbiological Analysis

Gencer, Hasim; Dalgıç, Nazan; Kafadar, İhsan; Kabakcı, Dilek; Öncül, Ümmühan

doi:10.5152/ced.2015.2096

Cited by 4 publications

(6 citation statements)

References 16 publications

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“…In our study, 27 patients (42%) had a single BCG scar, compared to 22.9% of definite TB cases in Gencer et al, and 48.8% in a study conducted in Nepal. 20,21 Furthermore, we found TST positivity as 51.5%, similar to the previous rates reported in Turkey; 53.3%. 11 Extrapulmonary TB is more frequent in children than in adults and seen in 25-35% of children with TB.…”

Section: Discussionsupporting

confidence: 89%

Clinical and Laboratory Evaluation of Pediatric Tuberculosis Cases in Light of Nutritional Indicators

Tezol¹,

Alakaya²,

Akar³

et al. 2019

Ankara Medical Journal

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Objectives: Pediatric tuberculosis is a major public health problem. Malnutrition characterized with wasting is prevalent among pediatric tuberculosis patients. We aimed to review pediatric tuberculosis cases by considering their nutrition manifestations. Materials and Methods:The study evaluated demographical, clinical, anthropometric, microbiological, histopathological and radiological characteristics of tuberculosis patients, retrospectively. Results:The study involved 77 tuberculosis cases. Sixty-three percent of the patients were male with a mean age of 9.32±4.91 years. Twenty-four patients (31%) diagnosed with definite tuberculosis, thirtynine patients (50%) with probable tuberculosis, and fourteen patients (18%) with latent tuberculosis infection. Acid resistant bacteria were observed in 33%, culture positivity was observed in 20%, both acid resistant bacteria and culture positivity was observed in 45% of definite diagnosed group. Forty percent of patients had pulmonary, 32% had extrapulmonary, 6% had miliary, 2% had both pulmonary and extrapulmonary tuberculosis. Pulmonary tuberculosis diagnosed patients were significantly older than extrapulmonary plus miliary group (p=0.003). Culture positivity rate was significantly higher in pulmonary, diagnostic histopathological sampling rate was significantly higher in extrapulmonary plus miliary group (p=0.019, p=0.012). Thirty seven percent of patients had a contact history, 23% of those had household contact, and the most common index cases were fathers. The tuberculin test was positive in 11 patients (45%) with definite and 15 patients (38%) with probable tuberculosis. No significant difference has been observed between definite and probable tuberculosis groups according to the sex, average age, symptom duration, tuberculin test positivity, Bacille Calmette-Guerin vaccine scar presence, contact history rate, hematologic tests, and anthropometric measurements (p>0.05). At the time of diagnosis mean (SD) values of height for age and weight for height medians [ 94.35 (7.50) % and 85.72 (6.92) %, respectively] refered to mild malnutrition, the same conditions were remaining at the end of treatment. When height for age taken into consideration the chronic malnutrated group was probable tuberculosis group. Weight for height (for <5 years old cases) and body mass index (for ≥5 years old cases) Z scores of sixteen patients were less than -2 SD value and these moderae malnutrated cases were remaining at the end of treatment. There was not a statistical significance between anthropometric measurements at the time of diagnosis and at the end of antituberculosis treatment (p>0.05). Conclusion: Nutrition status monitoring, correcting nutritional deficiencies and failures can be neglected in course of antituberculosis treatment. Tuberculosis management should be integrated with malnutrition monitoring in pediatric cases.

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Section: Discussionsupporting

confidence: 89%

Clinical and Laboratory Evaluation of Pediatric Tuberculosis Cases in Light of Nutritional Indicators

Tezol¹,

Alakaya²,

Akar³

et al. 2019

Ankara Medical Journal

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Section: Introductionmentioning

confidence: 99%

“…The progress and clinical findings of tuberculosis developing in children differ from those in adults since children possess fewer positive mycobacterial cultures and less specific findings and symptoms than adults. Hence, the diagnosis of tuberculosis is difficult and its presence is seldom demonstrated 6 . In childhood, there are problems in microbiological confirmation of tuberculosis diagnosis because of low bacillus load or the patients' inability to provide adequate sputum specimens 5 .…”

Section: Introductionmentioning

confidence: 99%

“…There are limited data on the incidence and clinical course of pediatric tuberculosis, which are mostly reported from low-burden countries 6 . This situation has recently sparked the researcher's interest since children represent 15 to 20% of all tuberculosis cases, which may increase up to 40% in countries where the disease is endemically seen 8 .…”

Section: Introductionmentioning

confidence: 99%

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Pediatrik pulmoner tüberküloz olgularının epidemiyolojik özellikleri ve tedavi sonuçları

Etiz

Altunsu²

2020

Cukurova Medical Journal

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ÖzPurpose: Pediatric tuberculosis constitutes a significant part of the global burden of tuberculosis. It is also important in that it shows that the burden of tuberculosis continues in society. We here aimed to examine the epidemiologic features and treatment outcomes of pediatric pulmonary tuberculosis cases who were registered to the Adana Tuberculosis Dispensaries. Material and Methods: Fifty-six pediatric patients aged 0-18 years with the diagnosis of pulmonary tuberculosis were examined retrospectively in terms of demographic data, clinical characteristics and drug susceptibility test results, as well as treatment outcomes. Data were collected through medical record review. Results: The mean age of the patients was 12.84 ± 5.62 years and 46.4% were female. Nine patients (16%) were aged 0-5 years, 4 (7.1%) were aged 5-10 years, 17 (30.3%) were aged 10-15 years and 26 patients (46.4%) were aged 15-18 years. Fourty-eight children was only pulmonary tuberculosis whereas eight possessed characteristics of both pulmonary and extrapulmonary tuberculosis. The most frequent symptoms were prolonged cough (80.3%) and weight loss (73.2%). Drug susceptibility test was performed only 22 patients. Multidrug resistance was determined in one patient. Among the 56 children for whom treatment outcome was documented, 39 (69.6%) were completed treatment, 16 (28.5%) were cured and 1 (1.7%) had treatment failure. Conclusion:It was observed that the signs and symptoms of our patients were compatible with the literature. The epidemiological characterization of pediatric patients with pulmonary tuberculosis helps to provide a better diagnostic approach in this population. Amaç: Pediatrik tüberküloz dünya çapında tüberküloz yükünün önemli bir kısmını oluşturmaktadır. Pediatrik tüberküloz toplumda tüberküloz yükünün devam ettiğini göstermesi bakımından da önemlidir. Çalışmamızda Adana ili Tüberküloz Dispanserlerine kayıtlı olan pediatrik pulmoner tüberküloz olgularının epidemiyolojik özelliklerini ve tedavi sonuçlarını incelemeyi amaçladık. Gereç ve Yöntem: Pulmoner tüberküloz tanısı konan 0-18 yaş arası 56 çocuk demografik veriler, klinik özellikler, ilaç duyarlılık testi ve tedavi sonuçları açısından geriye dönük olarak incelenmiştir. Veriler tıbbi kayıtlardan elde edilmiştir. Bulgular: Yaş ortalaması 12,84 ± 5,62 olan olguların %46,4'ü kız idi. Sıfır-5 yaş arası 9 olgu (%16), 5-10 yaş arası 4 olgu (%7,1), 10-15 yaş arası 17 olgu (%30,3), 15-18 yaş arası 26 olgu (%46,4) vardı. Kırk sekiz çocukta sadece akciğer, sekizinde hem akciğer hem de akciğer dışı tutulum vardı. En sık görülen semptomlar uzun süren öksürük (%80,3) ve kilo kaybı (%73,2) idi. Sadece 22 hastaya ilaç duyarlılık testi uygulandı. Bir hastada çoklu ilaç direnci belirlendi. Tedavi sonuçları incelenen 56 çocuktan 39'u (%69,6) tedavisini tamamladı, 16'sında (%28,5) kür ve 1'inde (%1,7) tedavi başarısızlığı olduğu kaydedildi. Sonuç: Hastalarımızın belirti ve bulgularının literatür ile uyumlu olduğu gözlendi. Pediatrik pulmoner tüberküloz olgularının

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“…Hastalığın tespit edilmesinde günlük pratikte kullanılan ek yöntemlere tüberkülin deri testi (TDT), göğüs radyografisi (GR) ve toraks bilgisayarlı tomografi (tBT) dahildir. Kontamitant bir hasta ile temas öyküsünün sorgulanması her zaman yardımcıdır (4).…”

Section: Introductionunclassified

Çocukluk Çağı Akciğer Tüberkülozu Tanısında Bilgisayarlı Tomografinin Yeri

Kaplan¹,

Akan²,

Dalgıç³

et al. 2019

J Pediatr Inf

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Bu çalışmanın amacı, çocukluk çağı akciğer tüberkülozu tanısında spesifik bilgisayarlı tomografi (BT) bulgularını tanımlamaktır. Gereç ve Yöntemler: Çalışmaya tüberküloz şüphesi olan 57 çocuk hasta dahil edildi. Toraks BT görüntüleri iki radyolog tarafından değerlendirildi. On yedi hasta kültür pozitifliği ile (mide açlık suyu, plevral sıvı, biyopsi veya bronkoalveoler lavaj örnekleri), 20 hasta ise klinik olarak tüberküloz tanısı aldı. Değerlendirilen kriterler lenf nodu büyümesi (> 1 cm), kalsifiye lenf nodları, konsolidasyon, kavitasyon, bronşiyal dallarda belirginleşme, plevral efüzyon, plevral kalınlaşma, ampiyem ve atelektazi olarak belirlendi. Tüberküloz hastaları (grup A) ve tüberküloz olmayan hastalar (grup B) arasındaki farklar Fisher exact testi kullanılarak analiz edildi. Bulgular: Lenf nodu büyümesi (> 1 cm), grup B'ye (5/20) kıyasla grup A'da (27/37) anlamlı olarak daha fazla bulundu (p< 0.01). B grubunda konsolidasyon (11/20), grup A'ya (7/37) kıyasla anlamlı olarak daha sık görüldü (p< 0.01). En büyük çapı > 1 cm olan lenf nodu büyümesinin duyarlılık ve özgüllüğü sırasıyla %73 ve %75 idi. Grup A'daki hastaların %43.2 (n= 16)'sinde plevral efüzyon, %40.5 (n= 15)'inde atelektazi, %18.9 (n= 7)'unda plevral kalınlaşma, %16.2 (n= 6)'sinde bronşiyal dallarda belirginleşme, %18.9 (n= 7)'unda konsolidasyon ve %13.5 (n= 5)'inde kalsifiye lenf nodları mevcuttu. B grubundaki hastaların ise %40 (n= 8)'ında plevral efüzyon, %35 (n= 7)'inde atelektazi, %20 (n= 4)'sinde plevral kalınlaşma, %20 (n= 4)'sinde ampiyem ve %15 (n= 3)'inde bronşiyal dallarda belirginleşme mevcuttu. Bu farklılıklar anlamlı değildi.

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Retrospective Evaluation of 35 Pediatric Tuberculosis Cases Proven by Histopathological and/or Microbiological Analysis

Cited by 4 publications

References 16 publications

Clinical and Laboratory Evaluation of Pediatric Tuberculosis Cases in Light of Nutritional Indicators

Clinical and Laboratory Evaluation of Pediatric Tuberculosis Cases in Light of Nutritional Indicators

Pediatrik pulmoner tüberküloz olgularının epidemiyolojik özellikleri ve tedavi sonuçları

Çocukluk Çağı Akciğer Tüberkülozu Tanısında Bilgisayarlı Tomografinin Yeri

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