Retrospective LC‐QTOF‐MS analysis searching for pharmaceutical metabolites in urban wastewater

Abstract

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LC-QTOF MS screening of more than 1,000 licit and illicit drugs and their metabolites in wastewater and surface waters from the area of Bogotá, Colombia

“…From our previous experience, the subsequent acquisition of reference standards has allowed confirmation of nearly all tentative identifications. This supports the high degree of reliability of tentative identification by using this technique [19].…”

Current use of high-resolution mass spectrometry in the environmental sciences

“…Thus, pharmaceutical metabolites have been retrospectively investigated in effluent wastewater samples previously analyzed only for parent pharmaceuticals. Several metabolites were tentatively identified without the need for additional analysis, illustrating the potential of QTOF MS in this field [70]. After tentative identification, subsequent acquisition of reference standards, when available, enabled ultimate confirmation of TPs detected in the samples.…”

Analysis, occurrence, fate and risks of proton pump inhibitors, their metabolites and transformation products in aquatic environment: A review

“…Although, PPIs are not regularly detected, considering their high use (Godman et al, 2009(Godman et al, , 2011Woldegiorgis et al, 2009) its analytical monitoring becomes relevant. In addition, in view of the recent reports dealing with the detection of many metabolites and environmental Transformation Products (TPs) in aqueous samples (Boix et al, 2013(Boix et al, , 2014Boleda et al, 2013;Hernández et al, 2011;Gracia-Lor et al, 2014;Ibáñez et al, 2016;López et al, 2014;Ibáñez et al, 2016), environmental contamination by PPIs should be checked and evaluated more thoroughly.…”