Retrospective study of preoperative CA199 combined control nutritional status score to predict the prognosis of distal cholangiocarcinoma

Abstract

Distal cholangiocarcinoma (dCCA) can be independently predicted by the Control of Nutritional Status (CONUT) score and CA199 levels. The purpose of this study was to evaluate the ability of the CONUT score and CA199 to predict surgical outcomes in patients with dCCA in combination with CA199. An examination of preoperative CONUT scores and serum CA199 levels was conducted retrospectively. The patients were categorized into four groups according to their preoperative CONUT scores and serum CA199 concentrations. The examination of the differences between overall survival (OS) and recurrence-free survival (RFS) was also conducted among different groups of patients.The preoperative CONUT-CA199 score is a prognostic factor that can independently forecast the results for surgical distal bile duct carcinoma patients. In the Cox multivariate regression analysis, lymph node metastasis positivity, decreased serum albumin (ALB), elevated CA199, elevated CONUT, and elevated significant unfavorable prognostic markers for distal bile duct carcinoma were discovered to be CA199-CONUT scores. Meanwhile, in the ROC curve analysis, compared to preoperative CA199 and preoperative CONUT scores separately, the combined preoperative CONUT-CA199 score exhibited a higher Area Under the Curve (AUC) value.Compared to any single factor, it provided more accurate prognostic information for postoperative distal bile duct cancer patients.Moreover, patients' OS and RFS are negatively correlated with their preoperative CONUT-CA199 score.Patients with postoperative distal bile duct carcinoma can be independently predicted by their preoperative CONUT-CA199 score, and patients with distal bile duct carcinoma may have a better postoperative outcome when their CONUT-CA199 scores are classified.