Retrospective Study on the Diagnostic Value of Full-Thickness Biopsies from the Stomach and Intestines of Dogs with Chronic Gastrointestinal Disease Symptoms

Kleinschmidt, Sven; Meneses, Felix; Nolte, Ingo; Hewicker‐Trautwein, M.

doi:10.1354/vp.43-6-1000

Cited by 57 publications

(58 citation statements)

References 10 publications

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“…A gastrointestinal mass was documented by abdominal imaging, and importantly, evidence of bowel perforation was found in 1 case. As with other gastrointestinal diseases, 23 our findings suggest that endoscopically obtained biopsies are useful to obtain a definitive diagnosis. Endoscopy is recommended as a less invasive diagnostic procedure than exploratory celiotomy, with the advantage of allowing intraluminal lesion visualization without celiotomy.…”

Section: Discussionsupporting

confidence: 64%

Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

Lyles

Panciera

Saunders

et al. 2009

Veterinary Internal Medicne

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Background: Eosinophilic inflammation of the gastrointestinal tract of dogs occurs in numerous disorders, typically resulting in diffuse intestinal thickening. Rarely, eosinophilic masses have been reported.Objective: Describe a series of dogs with 1 or more idiopathic eosinophilic gastrointestinal masses (IEGM) to better characterize the clinical features, treatment, and prognosis.Animals: Seven dogs with 1 or more gastrointestinal masses composed primarily of eosinophilic infiltrates for which no underlying cause was found.Methods: Retrospective case series.Results: Rottweilers and purebred, large breed dogs predominated. Dogs were middle-aged and typically had chronic signs of upper or lower gastrointestinal disease. Decreased appetite, vomiting, and evidence of gastrointestinal hemorrhage were present in the majority of cases. An abdominal or rectal mass was frequently noted on physical examination. Common laboratory abnormalities included peripheral eosinophilia, mature neutrophilia, hypoproteinemia, and hypocholesterolemia. The masses were histologically composed of moderate to severe eosinophilic infiltrates, which were often transmural and accompanied by fibrosis. All dogs treated with surgery alone died of complications of their disease. Treatment with corticosteroids and ivermectin improved clinical signs, caused resolution of eosinophilic infiltrates, and prolonged survival in most dogs treated medically.Conclusions and Clinical Importance: These findings suggest that the prognosis for dogs with IEGM may be good when recognized and managed appropriately. When surgery is performed, medical treatment should also be added.

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Section: Discussionsupporting

confidence: 64%

Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

Lyles

Panciera

Saunders

et al. 2009

Veterinary Internal Medicne

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“…Every effort must be made to obtain biopsy samples from as deep in the lamina propria as possible so that accurate differentiation is possible on histological examination (Tams and Webb 2011). On the other hand, full-thickness biopsy is still considered superior to endoscopic biopsy (Kleinschmidt et al 2006). In this lymphoma patient, endoscopically obtained samples were sufficient to establish the diagnosis of lymphoma in stomach, duodenum, ileum and colon, despite the presence of concomitant LPE.…”

Section: Discussionmentioning

confidence: 96%

Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report

Borska¹,

Husník²,

Fictum³

et al. 2018

Vet. Med. - Czech

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ABSTRACT:A four-year-old Bullmastiff weighing 44 kg was presented with a 14-day history of weight loss, vomiting and diarrhoea. Abdominal ultrasonography showed the presence of abdominal lymphadenopathy and thickening of the wall of the descending colon. Esophagogastroduodenoscopy and colonoscopy with biopsy were performed. Histological examination revealed a high-grade lymphoblastic lymphoma, flow cytometric analysis detected malignant cells of the immature B phenotype. PCR for antigen receptor rearrangement confirmed IgH monoclonality pointing together with immunophenotyping to B-cell lymphoma. The dog was treated using a multi-agent chemotherapy protocol. The overall survival time was 487 days. This was an unusual case of primary gastrointestinal B-lymphoblastic lymphoma in a dog with survival equivalent to that of the multicentric form.Keywords: canine; alimentary; lymphoid neoplasia; immunophenotyping; PARR; chemotherapy List of abbreviations:B-LBL = B-lymphoblastic lymphoma, FC = flow cytometry, FNAB = fine-needle aspiration biopsy, GI = gastrointestinal, LPE = lymphocytic-plasmacytic enteritis, PARR = polymerase chain reaction for antigen receptor rearrangement

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“…Specimens were fixed in 10% buffered formalin, then saturated with intermediate solutions, and finally embedded in paraffin blocks. Sections were stained with hematoxylin and eosin (Jacobs et al 1990, Kleinschmidt et al 2006. Histopathological evaluation of the colonic mucosa was performed using the NIS-Elements BR 2.30 programme (Nikon, Japan) under a Nikon Eclipse 80i optical microscope equipped with a Nikon PS -Fi1 digital camera (Eclipse 80i; Nikon, Japan) in the field of view (20 x 10).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

Can liquorice extract and herbal solution prevent colonic mucosa damage caused by robenacoxib in dogs?

Szweda¹,

Szarek²,

Lew³

et al. 2015

Polish Journal of Veterinary Sciences

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Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used in animals, especially in dogs, to manage pain due to inflammatory disease. This study investigated whether plant drugs can prevent mucosal injury induced by robenacoxib. We used fifteen healthy beagle dogs (7 male and 8 female) aged 4 months, weighing 4.2-5.1 kg at the beginning of the study. Endoscopy and biopsy of the colon were performed before and on the 21 day treatment with robenacoxib (1), robenacoxib, herbal solution with liquorice extract (2), placebo -an empty capsule (3). There were 5 animals in each group. The greatest microscopic damage in the colon was observed in animals which received robenacoxib. Plant drug administration reduced the severity of lesions in the colon when administered with robenacoxib (ARI = -0.15). Conclusion: concurrent administration of liquorice extract and plant solution with robenacoxib was associated with significant decreased severity of the robenacoxib-induced colonic mucosal lesions.

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Retrospective Study on the Diagnostic Value of Full-Thickness Biopsies from the Stomach and Intestines of Dogs with Chronic Gastrointestinal Disease Symptoms

Cited by 57 publications

References 10 publications

Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

Idiopathic Eosinophilic Masses of the Gastrointestinal Tract in Dogs

Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report

Can liquorice extract and herbal solution prevent colonic mucosa damage caused by robenacoxib in dogs?

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