Reuse of a previously transplanted kidney: does success come with a price?

Kadambi, Pradeep V.; Chon, W. James; Josephson, Michelle A.; Desai, Amishi; Thistlethwaite, J. Richard; Harland, Robert C.; Meehan, Shane M.; Garfinkel, Marc R.

doi:10.1093/ckj/sfs086

Cited by 15 publications

(24 citation statements)

References 14 publications

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“…The most common cause of the loss of a kidney allograft is the death of a patient with a functioning graft [11, 15, 16]. In the 30 years since Al-Hasani et al first reported the reuse of a transplanted kidney [4], there have been only 10 case reports of the reuse of a kidney [4–13].…”

Section: Discussionmentioning

confidence: 99%

Successful reuse of a transplanted kidney 9 years after initial transplantation: 4-year follow-up

et al. 2018

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BackgroundKidney transplantation is the preferred renal replacement therapy for patients with end-stage renal disease, but the waiting list for kidneys continues to grow because of a shortage of donor organs. The reuse of transplanted kidneys would seem to be a good approach to expand the pool of available organs. Here, we describe the reuse of a kidney 9 years after the initial transplantation. At 4-year follow-up, the second recipient is showing good renal function.Case presentationIn 2005, a kidney was transplanted from a 40-year-old man, who suffered brain death due to an intracranial hemorrhage, into a 45-year-old man. Nine years later, the recipient suffered a ruptured cerebral aneurysm, resulting in brain death. The kidney was re-transplanted into a 40-year-old man with diabetic nephropathy who had received hemodialysis for 5 years. During 4 years of follow-up, the graft has functioned well.ConclusionsThis case demonstrates the successful regrafting of a transplanted kidney. We believe this is the longest period for reuse of kidney after initial transplantation. The outcome suggests that a well-functioning transplanted kidney can be reused years after transplantation.

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Section: Discussionmentioning

confidence: 99%

Successful reuse of a transplanted kidney 9 years after initial transplantation: 4-year follow-up

et al. 2018

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“…Donation of organs from recipients late after initial transplantation carries risks of transmission of multidrug-resistant organisms or organisms that typically occur later post transplant (eg, Cryptococcus, Nocardia), as demonstrated in a report of a suspected transmission from an organ recipient of ganciclovir-resistant CMV through kidney transplantation. 4 Our report has several limitations. First, we were unable to identify HSV-2 in the initial organ donor's clinical samples.…”

Section: Discussionmentioning

confidence: 79%

“…Our report illustrates that particular care must be taken to ensure that an infectious complication did not contribute to the potential donor's death. Donation of organs from recipients late after initial transplantation carries risks of transmission of multidrug‐resistant organisms or organisms that typically occur later post transplant (eg, Cryptococcus , Nocardia ), as demonstrated in a report of a suspected transmission from an organ recipient of ganciclovir‐resistant CMV through kidney transplantation …”

Section: Discussionmentioning

confidence: 99%

“…Solid organ transplantation is life‐saving for many patients with end‐stage organ disease but a significant disparity exists in the supply of organs for transplant and the number of patients registered on waiting lists . This imbalance has led to increasing efforts to use organs from non‐traditional sources, including considering previous organ recipients as donors . From 2000 to 2012 in the United States, 762 organs were recovered from 718 donors who had been previous organ recipients .…”

Section: Introductionmentioning

confidence: 99%

“…1 This imbalance has led to increasing efforts to use organs from non-traditional sources, including considering previous organ recipients as donors. [2][3][4] From 2000 to 2012 in the United States, 762 organs were recovered from 718 donors who had been previous organ recipients. 5 Reports on the outcomes of this practice are limited, although rare donor-derived disease transmissions have been reported to organ procurement agencies (M.G.…”

Section: Introductionmentioning

confidence: 99%

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Herpes simplex virus‐2 transmission following solid organ transplantation: Donor‐derived infection and transplantation from prior organ recipients

Macesic

Abbott

Kaye

et al. 2017

Transplant Infectious Dis

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Donor-derived HSV infection affected two clusters of recipients because of transplantation of organs from a prior organ recipient. HSV should be considered as a possible cause of illness in febrile SOT recipients in the immediate post-transplant period and may cause disseminated disease and re-infection in HSV-2-seropositive recipients. Testing of HSV serology and prophylaxis may be considered in SOT recipients not receiving cytomegalovirus prophylaxis.

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Successful Transplant of Two Kidneys Harvested from a Young Brain-Dead Liver Transplant Recipient

et al. 2016

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Efforts to increase the dismal deceased renal transplantation (DRT): live renal transplantation (LRT) ratio in our country have gathered momentum recently, with governmental and non-governmental projects focussing on building public awareness and capacity-building, and appropriate legislation. Worldwide, efforts at increasing the number of organs from the deceased pool have focussed on the use of 'expanded criteria donors', including deceased cardiac donors (DCD). 'Reuse' transplant, where an organ is transplanted after removal from the first recipient, is a rare strategy, used more commonly in liver than in kidney transplantation. Exceptional circumstances, where other organs have been harvested from transplant recipients, are rare. We describe the successful transplants of two renal grafts obtained from a 19-year-old brain-dead liver transplant recipient; this is probably the second case in English-language literature. A 19-year-old male patient with hepatitis E-induced fulminant hepatic failure underwent live-related liver transplantation. On postoperative day 2, cerebral edema set in, and the patient was declared brain-dead. Despite the economical and emotional trauma, the family opted for donation of the well-perfused kidneys. The kidneys were transported in HTK solution (histidine-tryptophan-ketoglutarate) to our centre. Recipient 1 was a 32-year-old woman (B positive) and recipient 2 was a 29-year-old man (also B positive); the kidneys were placed extraperitoneally and anastomosed end-to-side to the external iliac artery and vein. Recipient 2 experienced delayed graft function; however, both are doing well 15 months posttransplant.

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Reuse of a previously transplanted kidney: does success come with a price?

Cited by 15 publications

References 14 publications

Successful reuse of a transplanted kidney 9 years after initial transplantation: 4-year follow-up

Successful reuse of a transplanted kidney 9 years after initial transplantation: 4-year follow-up

Herpes simplex virus‐2 transmission following solid organ transplantation: Donor‐derived infection and transplantation from prior organ recipients

Successful Transplant of Two Kidneys Harvested from a Young Brain-Dead Liver Transplant Recipient

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