2010
DOI: 10.1111/j.1423-0410.2010.01387.x
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Revalidation and update of the TASH‐Score: a scoring system to predict the probability for massive transfusion as a surrogate for life‐threatening haemorrhage after severe injury

Abstract: When the original TASH-Score was applied onto the 2004-2007 TR-DGU database, a slight increase in discrimination was observed while precision was considerably lower. The predicted rate for MT within the development dataset was 13·9% while the observed incidence was 14·1%. In contrast, the predicted rate for MT within the revalidation dataset was 11·7%, while the observed rate was 8·4%. The logistic function to calculate MT probability was modified, and the TASH-Score was again evaluated against the most recent… Show more

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Cited by 140 publications
(111 citation statements)
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“…Therefore, the pathophysiologic mechanism of ATC has been emphasized as being different from that of DIC [13,27,41,54]. However, thrombin generation with marked decrease in fibrinogen and D-dimer elevation was observed [13,27,41,54], suggested to be consistent with the pathophysiology of DIC.…”
Section: Atc As Disseminated Intravascular Coagulation With a Fibrinomentioning
confidence: 97%
“…Therefore, the pathophysiologic mechanism of ATC has been emphasized as being different from that of DIC [13,27,41,54]. However, thrombin generation with marked decrease in fibrinogen and D-dimer elevation was observed [13,27,41,54], suggested to be consistent with the pathophysiology of DIC.…”
Section: Atc As Disseminated Intravascular Coagulation With a Fibrinomentioning
confidence: 97%
“…Acute traumatic coagulopathy is the key pathophysiological derangement, driven by tissue damage, which results in TF exposure, shock and hypoxia, and must be mitigated to successfully resuscitate the patient [66,67].…”
Section: The Importance Of Rapidly Identifying Coagulopathymentioning
confidence: 99%
“…Algorithms based on these scores shift clinical management from a reactive to a proactive stance [66][67][68][69][70][71]. Unfortunately, none of these scoring systems identify all patients at risk of ATC and death due to bleeding.…”
Section: Predicting Coagulopathymentioning
confidence: 99%
“…by using coagulation factor concentrates instead of allogeneic blood products - might change transfusion requirements in patients undergoing liver transplantation [4,23,41,42,43,44,45,46]. Therefore, this predictive model has to be re-validated in other liver transplant patient populations using the same and different thromboelastometry-guided bleeding management algorithms [90]. …”
Section: Discussionmentioning
confidence: 99%