Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts

Hossain, Shakhawath; Kneiszl, Rosita; Larsson, Per

doi:10.1039/d3nr05571j

Nanoscale

2023

DOI: 10.1039/d3nr05571j

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Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts

Shakhawath Hossain,

Rosita Kneiszl,

Per Larsson

Abstract: Molecular-level insights can guide the design of improved permeability enhancer-based dosage forms, allowing for precise control of peptide release profiles near the intended absorption site.

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Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts

Abstract: Molecular-level insights can guide the design of improved permeability enhancer-based dosage forms, allowing for precise control of peptide release profiles near the intended absorption site.

Cited by 4 publications

References 45 publications

Preparation, separation and identification of novel hypocholesterolemic peptides from wheat germ: An in vitro and in silico study

Preparation, separation and identification of novel hypocholesterolemic peptides from wheat germ: An in vitro and in silico study

Interactions of oral permeation enhancers with lipid membranes in simulated intestinal environments

Characterization of macrocyclic peptide drug interactions with bile salts and biorelevant colloids via single amino acid mutations and 1H nuclear magnetic resonance (NMR) spectroscopy

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