[Retracted] Revealing the Longevity Code of Humans with up to Extreme Longevity in Guangxi Based on Physical Examination Indicators and Personalized Biomarkers of Aging

Abstract

Background. The pursuit of health and longevity is the eternal theme of humanity. Guangxi has a remarkable phenomenon of longevity in long-lived regions and ranks with the highest number of longevity villages in China, thus providing a natural advantage for health longevity research. Methods. In this study, we selected 117 natives of a longevity area in Guangxi, covering a large age range (38-118 years old) as subjects to measure peripheral leukocyte telomere length (LTL). Nineteen physical examination indicators and two inflammatory factor levels were measured. Results. Pearson’s analysis revealed a significant negative correlation between age and LTL ( r = − 0.3694 , p = 0.003 ), as well as alanine aminotransferase, albumin, total bilirubin, direct bilirubin, γ-glutamyltransferase, triglycerides, Interleukin-10, and tumor necrosis factor type-α. Systolic blood pressure and blood urea nitrogen were positively correlated with age. In addition, LTL decreased in people aged 38–89 years, and an upward trend was observed in people aged older than 90 years. Conclusions. Longevity individuals have characteristics, such as longer LTL, good hepatic function, and lower triglycerides and inflammation levels.

Protection effect of gut microbiota composition and acetate absorption against hypertension-induced damages on the longevity population in Guangxi, China

“…Bama, Donglan, and Fengshan are the three most famous longevity populations in Guangxi, and which prevalence of the three counties was 35.6, 31.4, and 28.5 centenarians/100,000 citizens in 2019, respectively ( 13 ). In our previous study, 66.7% of the population aged >60 in this longevity area had SBP≥140 mmHg ( 22 ). This co-existence of longevity and hypertension is well worth investigating.…”

Exploring the effects of the dietary fiber compound mediated by a longevity dietary pattern on antioxidation, characteristic bacterial genera, and metabolites based on fecal metabolomics

“…Bama County in Guangxi is a world-renowned longevity town, where the phenomenon of longevity is highlighted [ 1 ]. Our research team conducted a lot of research on the dietary characteristics of the longevity population in the early stage, and found that the traditional diet in the Bama area is mainly based on the food intake of plant foods, such as coarse grains (Taro, hemp, corn, cassava, etc.…”

1H NMR-Based Metabolomics Reveals the Intrinsic Interaction of Age, Plasma Signature Metabolites, and Nutrient Intake in the Longevity Population in Guangxi, China

“…In addition, an examination of physical health indicators in subjects of the longevity regions of Hechi by our research team revealed that long-lived older adults, especially centenarians, had a good hepatic function, lower lipid levels, and lower levels of inflammation. This makes it more meaningful to explore the health and longevity phenomenon in Guangxi from the perspective of metabolomics in combination with dietary characteristics [16]. In the present study, diet-related signature metabolites of longevity were evaluated through the analysis of plasma metabolites and dietary characteristics of the longevity population in the Hechi region.…”