Reverse End-to-Side Neurotization

Isaacs, Jonathan; Allen, Diane M.; Chen, Long En; Nunley, James A.

doi:10.1055/s-2005-862780

Cited by 60 publications

(61 citation statements)

References 10 publications

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“…However, the origin of the regenerative fibers could not be determined. These findings reaffirm those reported by Isaacs et al 20,21 In a study on reverse end-to-side neurotization, Isaacs et al 20 reported findings from groups similar to G3 and G4 of our study.…”

Section: Group Wctm (G) Mdmf (µM)supporting

confidence: 79%

“…Isaacs et al 20 reported that no contractions of the long digital extensor muscle were observed when the peroneal nerve was sectioned proximally to the end-to-side neurorrhaphy, although histological analyses revealed immature axons in the epineural spaces of the peroneal nerve. This shows that if the regenerative fibers had originally been from the tibial nerve, they would not have made contact with the motor terminals.…”

Section: Group Wctm (G) Mdmf (µM)mentioning

confidence: 99%

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Double muscle innervation using end-to-side neurorrhaphy in rats

et al. 2012

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CONTEXT AND OBJECTIVE: One of the techniques used for treating facial paralysis is double muscle innervation using end-to-end neurorrhaphy with sectioning of healthy nerves. The aim of this study was to evaluate whether double muscle innervation by means of end-to-side neurorrhaphy could occur, with maintenance of muscle innervation. DESIGN AND SETTING: Experimental study developed at the Experimental Research Center, Faculdade de Medicina de Botucatu, Unesp. METHODS: One hundred rats were allocated to five groups as follows: G1, control group; G2, the peroneal nerve was sectioned; G3, the tibial nerve was transected and the proximal stump was end-to-side sutured to the intact peroneal nerve; G4, 120 days after the G3 surgery, the peroneal nerve was sectioned proximally to the neurorrhaphy; G5, 120 days after the G3 surgery, the peroneal and tibial nerves were sectioned proximally to the neurorrhaphy. RESULTS: One hundred and fifty days after the surgery, G3 did not show any change in tibial muscle weight or muscle fiber diameter, but the axonal fiber diameter in the peroneal nerve distal to the neurorrhaphy had decreased. Although G4 showed atrophy of the cranial tibial muscle 30 days after sectioning the peroneal nerve, the electrophysiological test results and axonal diameter measurement confirmed that muscle reinnervation had occurred. CONCLUSION: These findings suggest that double muscle innervation did not occur through end-to-side neurorrhaphy; the tibial nerve was not able to maintain muscle innervation after the peroneal nerve had been sectioned, although muscle reinnervation was found to have occurred, 30 days after the peroneal nerve had been sectioned. RESUMO CONTEXTO E OBJETIVO:Uma das técnicas utilizadas para tratamento da paralisia facial é a dupla inervação muscular com neurorrafia término-terminal, seccionando-se nervos sadios. O objetivo deste trabalho foi avaliar a ocorrência de dupla inervação muscular através de neurorrafia término-lateral e a manutenção da inervação. TIPO DE ESTUDO E LOCAL: Estudo experimental desenvolvido no Centro de Pesquisa Experimental da Faculdade de Medicina de Botucatu, Unesp. MÉTODOS: Cem ratos foram distribuídos em cinco grupos: G1, controle; G2, secção do nervo fibular; G3, o nervo tibial foi seccionado e o coto proximal suturado na lateral do nervo fibular íntegro; G4, 120 dias após a cirurgia do G3, o nervo fibular foi seccionado proximal à neurorrafia; G5, 120 dias após a cirurgia do G3, os nervos fibular e tibial foram seccionados proximal à neurorrafia. RESULTADOS: Após 150 dias da cirurgia, não foi observada variação na massa do músculo tibial ou no diâmetro das fibras musculares no G3, porém, houve redução do diâmetro da fibra axonal do nervo fibular distal à neurorrafia. Embora, no G4, tenha ocorrido atrofia do músculo tibial cranial 30 dias após a secção do nervo fibular, os resultados do teste eletrofisiológico e da medida do diâmetro axonal confirmaram a ocorrência de reinervação muscular. CONCLUSÃO: Estes resultados sugerem que a dupla inervaç...

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Section: Group Wctm (G) Mdmf (µM)supporting

confidence: 79%

Section: Group Wctm (G) Mdmf (µM)mentioning

confidence: 99%

Double muscle innervation using end-to-side neurorrhaphy in rats

et al. 2012

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“…In 2005, Isaacs et al demonstrated that donor motor axons could grow through an RETS nerve transfer and successfully reinnervate target muscle, as long as the recipient nerve had been injured and the muscle had experienced denervation. 38 Fujiwara et al then performed a series of experiments attempting to augment a primary nerve repair with the addition of an RETS nerve transfer. In their model of an RETS transfer of the left sciatic nerve to the right sciatic nerve, they saw better sensory and motor functional recovery than with transection and repair of the right sciatic nerve without augmentation.…”

Section: Discussionmentioning

confidence: 99%

Reverse End-to-Side Nerve Transfer: From Animal Model to Clinical Use

Kale¹,

Glaus²,

Yee³

et al. 2011

The Journal of Hand Surgery

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“…ESN allows the passage of nerve impulses through the reinnervated region 29,30 , however, the functional demand of a patient goes beyond the passage of the stimulus by the junction between the donor and the recipient nerve. A healthy muscle must have the innate ability to produce tension during contraction to produce movement.…”

Section: Introductionmentioning

confidence: 99%

Effect of electrical stimulation of the cranial tibial muscle after end-to-side neurorrhaphy of the peroneal nerve in rats

Maciel

Viterbo

Chinaque³

et al. 2013

Acta Cir. Bras.

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PURPOSE:To investigate the efficiency of electrical stimulation in the muscle maintenance and nerve regeneration after end-to-side neurorrhaphy (ESN). METHODS:Sixty male Wistar rats (Rattus norvegicus) were divided into four experimental groups. Control group (Control), Denervated Group (Denervated); Group with End-to-side neurorrhaphy (ESN); Group with End-to-side neurorrhaphy and electrical stimulation (ESN + ES). We perform electrical stimulation in rats after they had undergone muscle reinnervation by ESN. We collected morphometric and functional data. RESULTS:When comparing the mass of the treated side of cranial tibial muscle (CTM) and that of normal side of CTM, the group ESN + ES (26.12%) exhibited lower mass loss than that of group ESN (37.23%). The peroneal functional index showed that group ESN + ES equaled that of the Control group and showed an evolution of 60.5% while group ESN showed an evolution of 9.5%. In measuring maximum strength of CTM, the group ES + ESN outperformed group ESN. The muscle and nerve morphometry showed superiority of group ES+ESN over ESN group in all parameters. CONCLUSION:Electrical stimulation is an effective means of maintaining functional muscle and nerve regeneration after end-to-side neurorrhaphy.

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Reverse End-to-Side Neurotization

Cited by 60 publications

References 10 publications

Double muscle innervation using end-to-side neurorrhaphy in rats

Double muscle innervation using end-to-side neurorrhaphy in rats

Reverse End-to-Side Nerve Transfer: From Animal Model to Clinical Use

Effect of electrical stimulation of the cranial tibial muscle after end-to-side neurorrhaphy of the peroneal nerve in rats

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