The high-tech equipment industry brings complex industrial products to the market with high speed, enhanced functionality, a better cost-performance ratio, and greater integration into customer workflows. Driven by digitalization, the complexity of these systems continues to grow steeply. To manage this complexity, continuous innovation in systems engineering methodologies is needed. TNO-ESI targets to 1) create impactful and industrially applicable systems engineering methodologies and 2) provide innovation support to the industry to get these applied in an industrial context. The ESI research program is defined through a roadmapping process that follows two tracks: a roadmap that maps industry needs and related research and development requirements and a roadmap that describes the developments in the expertise areas necessary for addressing these industry needs. In this paper, we describe the ESI mission, our way of working and activities, and explain the roadmapping process and the roadmaps.