Reversible dilated cardiomyopathy caused by hypothyroidism

Khochtali, I.; Hamza, N.; Harzallah, O.; Hamdi, Sonia; Saad, Jamel; Golli, M.; Mahjoub, S.

doi:10.1186/1755-7682-4-20

Cited by 31 publications

(31 citation statements)

References 7 publications

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“…Thyroid hormone has a great effect on the heart and vascular system 1). The heart is sensitive to changes in thyroid hormones, and cardiac disorders are commonly associated with both hyper- and hypothyroidism 3)4).…”

Section: Introductionmentioning

confidence: 99%

Dilated Cardiomyopathy Secondary to Hypothyroidism: Case Report with a Review of Literatures

Seol

Lee

Kim

et al. 2014

J Cardiovasc Ultrasound

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To date, it has been well documented that there is a relationship between alterations in thyroid hormones and cardiac dysfunction. We experienced a case of a 36-year-old man with dilated cardiomyopathy (DCM) accompanied by undiagnosed primary hypothyroidism. In the current case, there was a significant improvement in the cardiac function following heart failure management and thyroid hormone replacement. Our case highlights that clinicians should consider the possibility of hypothyroidism as a cause of DCM.

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Section: Introductionmentioning

confidence: 99%

Dilated Cardiomyopathy Secondary to Hypothyroidism: Case Report with a Review of Literatures

Seol

Lee

Kim

et al. 2014

J Cardiovasc Ultrasound

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“…The manifestations of myxoedema and HF improved during therapy with desiccated thyroid. More recently, cases of hypothyroidism and reversible dilated cardiomyopathy have been reported (87,88). Changes in myocardial gene expression (aMHC and phospholamban) were documented by measuring mRNA extracted from endomyocardial biopsy specimens of a hypothyroid patient with dilated cardiomyopathy before and after T 4 replacement therapy (88).…”

Section: Hf and Hypothyroidismmentioning

confidence: 99%

MECHANISMS IN ENDOCRINOLOGY: Heart failure and thyroid dysfunction

Biondi

2012

European Journal of Endocrinology

248

187

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Context: Heart failure (HF) is a major cause of morbidity and mortality in Europe and in the United States. The aim of this review article was to assess the results of the prospective studies that evaluated the risk of HF in patients with overt and subclinical thyroid disease and discuss the mechanism of this dysfunction. Evidence Acquisition: Reports published with the following search terms were searched:, thyroid, hypothyroidism, hyperthyroidism, subclinical hyperthyroidism, subclinical hypothyroidism, levothyroxine, triiodothyronine, antithyroid drugs, radioiodine, deiodinases, clinical symptoms, heart rate, HF, systolic function, diastolic function, systemic vascular resistance, endothelial function, amiodarone and atrial fibrillation. The investigation was restricted to reports published in English. Evidence Synthesis: The outcome of this analysis suggests that patients with untreated overt thyroid dysfunction are at increased risk of HF. Moreover, persistent subclinical thyroid dysfunction is associated with the development of HF in patients with serum TSH !0.1 or O10 mU/l. Conclusions: The timely recognition and effective treatment of cardiac symptoms in patients with thyroid dysfunction is mandatory because the prognosis of HF may be improved with the appropriate treatment of thyroid dysfunction.

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“…It has long been shown that appropriate thyroid hormone replacement can restore LV function and even reverse pericardial effusions caused by hypothyroidism 2 4. Although the merits of treating subclinical hypothyroidism have been debated, Razvi et al 5 recently demonstrated improvement in cardiovascular risk factors and fatigue with L-thyroxine therapy 6…”

Section: Discussionmentioning

confidence: 99%

Hypothyroid cardiomyopathy in a patient post-doxorubicin chemotherapy

2016

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Hypothyroidism may cause decreased cardiac output and heart failure-and when severe, bradycardia and pericardial effusions may develop. Chemotherapies, particularly doxorubicin, are known and often irreversible causes of cardiomyopathy. As such, when cardiomyopathy develops in patients who have been exposed to anthracycline chemotherapy, the importance of ruling out other reversible causes such as hypothyroidism cannot be overstated. We present a case of acute systolic heart failure in a patient post-doxorubicin chemotherapy and radiation therapy for alveolar rhabdomyosarcoma, found to have severe hypothyroidism as a reversible cause of cardiomyopathy.

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Reversible dilated cardiomyopathy caused by hypothyroidism

Cited by 31 publications

References 7 publications

Dilated Cardiomyopathy Secondary to Hypothyroidism: Case Report with a Review of Literatures

Dilated Cardiomyopathy Secondary to Hypothyroidism: Case Report with a Review of Literatures

MECHANISMS IN ENDOCRINOLOGY: Heart failure and thyroid dysfunction

Hypothyroid cardiomyopathy in a patient post-doxorubicin chemotherapy

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