Reversible Optic Disk Cupping and Visual Field Improvement in Adults With Glaucoma

Katz, L. Jay; Spaeth, George L.; Cantor, Louis B.; Poryzees, Effie; Steinmann, William C.

doi:10.1016/0002-9394(89)90492-3

Cited by 122 publications

(76 citation statements)

References 21 publications

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“…9,10 This distortion may be permanent in advanced cases, but there is mounting evidence that in less advanced disease, both the disc and visual field can improve when the IOP is lowered. 26,27 It is postulated that one of the main reasons for an apparent improvement in optic nerve appearance with IOP reduction is a reduction in the posterior bowing of the lamina cribrosa, giving relief to these compressed nerve fibre bundles. 10 Apparent improvement in the appearance of the ONH has been well documented in children.…”

Section: Discussionmentioning

confidence: 99%

Effect of trabeculectomy on RNFL thickness and optic disc parameters using optical coherence tomography

Raghu

Pandav

Kaushik

et al. 2012

Eye

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Purpose To study the change in retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters using optical coherence tomography (Stratus OCT 3) after trabeculectomy in adult patients with glaucoma. Methods A total of 17 patients with glaucoma undergoing trabeculectomy were recruited. Average and quadrant RNFL thickness measurements, vertical integrated rim area, horizontal integrated rim width, disc area, cup area, and rim area were measured using Stratus OCT within a week before surgery and at 1 week, 1 and 3 months postoperatively. Main outcome measures were change in RNFL and ONH parameters. Pre-and postoperative values were analysed using the Wilcoxon signed-rank test. Results Intraocular pressure (IOP) reduced from 30.23±9.02 mm Hg preoperatively to 9.52 ±2.42 mm Hg at 1 week, 12.35±4.59 mm Hg at 1 month, and 13.6 ±2.31 mm Hg at 3 months after trabeculectomy. A significant increase in average (P ¼ 0.019) and inferior RNFL (P ¼ 0.038) thickness was observed 1 week after surgery. At 3 months postoperatively, they had reverted to preoperative values. RNFL thickness change had no correlation with IOP change. Mean optic disc cup area decreased from 2.39±0.52 mm 2 preoperatively to 2.14 ± 0.52 mm 2 at 1 week (P ¼ 0.022), 2.22 ± 0.53 mm 2 at 1 month (P ¼ 0.038), and 2.27 ± 0.60 mm 2 at 3 months (P ¼ 0.071). No significant change was found in other ONH parameters. Conclusions Short-term fluctuations were noted in RNFL thickness and ONH postoperatively following glaucoma filtration surgery. RNFL thickness temporarily increased and cup area decreased but the values reverted to normal within 3 months.

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Section: Discussionmentioning

confidence: 99%

Effect of trabeculectomy on RNFL thickness and optic disc parameters using optical coherence tomography

Raghu

Pandav

Kaushik

et al. 2012

Eye

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“…Hem preoperatif değerle postoperatif 1. yıl arasındaki farkın (p=0,23; eşleştirilmiş t testi), hem de 1. yıldan sonra görülen değişimin istatistiksel olarak anlamlı olmadığı tespit edildi. Literatürde Katz [12] ve arkadaşları 75 gözden oluşan çalışmalarında 63 gözün görme alanını değerlendirebilmişler ve bunların %31'inde trabekülektomiden sonra görme alanı skorunda düzelme olduğunu saptamışlardır. Akafo [13] ve arkadaşları da ortalama 9,2 yıl takip süresi olan 81 gözün 36'sında görme alanını değerlendirebilmiş ve gözlerin %83'ünde görme alanında kayıp; %17'sinde düzelme olduğunu görmüşlerdir.…”

Section: Discussionunclassified

Long term results of trabeculectomy surgery

Evliyaoglu

Akpolat²,

Kurt³

2015

J Clin Exp Invest

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Objective: Evaluation of long-term results of primary trabeculectomy operation Methods: The cases that are followed up with diagnosis of glaucoma in Okmeydanı Training and Research Hospital Eye Clinic between January 2000 and December 2001 were evaluated retrospectively. All of the cases, despite maximum therapy, have high intraocular pressure (IOP), undergone primary trabeculectomy operation, are followed at least 6 months and regularly followed through 10 years were included in this study. IOP with or without medical treatment 18mmg or less than 18 mmHg accepted as successful. IOL pressure measured with applanation tonometry.Results: 89 eyes of 70 cases were included in this study. The cases included in the study, 42 male (60%), and 28 (40%) were female. th year an 10 th year (p < 0.01). The follow-up period in the study was 91.10 ± 40.15 months (6-120 months). Conclusion:Primary trabeculectomy can be considered as an alternative treatment procedure especially in patients who does not use drugs regularly and unable to attend regular medical examination. J Clin Exp Invest 2015; 6 (3): 263-268

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“…A significant difference in the SAP mean deviation index was found, but not in the pattern standard deviation. Although different studies describe an improvement of visual field after reducing IOP in glaucoma eyes, [6][7][8]18 this improvement has not been reported by other studies. 15,16 Heijl et al 15 analysed 42 glaucoma eyes after laser trabeculoplasty and found no reduction of visual field defects.…”

Section: Discussionmentioning

confidence: 99%

“…2,4,6,7,13,15,16,18 Some possible reasons for the discrepancies found among the studies could be related to sample size, baseline IOP level, disease stage, treatment modality, as well as spontaneous fluctuations of the visual field (long-term fluctuation) and the influence of learning.…”

Section: Discussionmentioning

confidence: 99%

“…4 However, several studies have reported partial recovery from visual field defects in some patients, which is related to the IOP reduction achieved in each eye. [5][6][7][8] During the natural course of glaucomatous optic neuropathy (GON), certain types of functional vision loss may occur earlier than those detected by standard automated perimetry (SAP). 4,9 Alterations in contrast sensitivity (CS) have been observed before any visible nerve fiber layer damage or SAP visual field defects.…”

Section: Introductionmentioning

confidence: 99%

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Changes in visual function after intraocular pressure reduction using antiglaucoma medications

Prata

Piassi

Melo

2008

Eye

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Purpose To evaluate the change in visual function after starting glaucoma treatment and correlate this to a decrease in intraocular pressure (IOP) Conclusions Visual quality perception, visual field mean deviation index, and CS at higher frequencies improve after starting glaucoma therapy. However, no correlation was found between IOP reduction and changes in visual function, and no differences were found in visual function when the three medications studied were compared.

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Reversible Optic Disk Cupping and Visual Field Improvement in Adults With Glaucoma

Cited by 122 publications

References 21 publications

Effect of trabeculectomy on RNFL thickness and optic disc parameters using optical coherence tomography

Effect of trabeculectomy on RNFL thickness and optic disc parameters using optical coherence tomography

Long term results of trabeculectomy surgery

Changes in visual function after intraocular pressure reduction using antiglaucoma medications

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