Reversible post-pregabalin peripheral edema in a spinal cord injury patient

Abstract

Study design: Case report. Objectives: To report a case of paraplegia with limb edema caused by pregabalin. Setting: Turkish Armed Forces Rehabilitation Center, Ankara, Turkey. Case report: A 40-year-old male patient with T11 paraplegia had the complaint of swelling in both the lower limbs. He had been given pregabalin because of the neuropathic pain in both the lower limbs. At 10 months, the patient has experienced edema in lower limbs. There was severe edema in both legs, ankles and feet, more evident on the left. Venous Doppler ultrasound was normal on both sides. Blood tests for possible etiologies were normal. No other etiology could be found. The edema was considered to be caused by pregabalin and the medicine was ceased gradually. The edema resolved completely in 2 weeks. Conclusion: Pregabalin, which is one of medications used for neuropathic pain, might cause limb edema, that is, a condition needs differential diagnosis. This is particularly important for patients with spinal cord injuries (SCIs). Such adverse effect of pregabalin should be kept in mind as an etiology of limb edema in SCI management.

Evidence of a gabapentinoid and diuretic prescribing cascade among older adults with lower back pain

“…Previous evidence relating to the incidence of this prescribing cascade is limited to case reports, meaning the true population‐based incidence of this potentially problematic practice was unknown 14–16 . By conducting a comprehensive cohort study using population‐level data, we addressed this gap and established temporality.…”

Pregabalin-Associated Heart Failure Decompensation in a Patient With a History of Stage I Heart Failure

“…It has been reported that pregabalin is associated with a 10% to 15% prevalence of peripheral edema and weight gain, with cases reported both in patients without a previous history of cardiac failure 1,4-6 and with HF. 1,7-10 The mechanism of the development of HF symptoms is unknown.…”

Construção de diagnósticos de enfermagem para pessoas com lesão medular em reabilitação

“…O processo complexo Fluidos e Eletrólitos envolve a manutenção do equilíbrio entre os fluidos e os eletrólitos do organismo (4) . Devido à imobilidade e/ou à permanência prolongada na posição sentada, é comum a ocorrência de edema periférico em pessoas com LM, caracterizado pelo acúmulo de líquido no espaço intersticial, acometendo, principalmente, os membros inferiores (26) . Diante do exposto, é necessário prevenir e controlar o edema periférico nesses pacientes.…”