Reversing β-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime

Eumkeb, Griangsak; Sakdarat, Santi; Siriwong, Supatcharee

doi:10.1016/j.phymed.2010.09.003

Cited by 105 publications

(106 citation statements)

References 27 publications

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“…Viable counts for each absorbance reading were determined in triplicate using an agar plate counting method [8,10].…”

Section: Bacterial Suspension Standard Curvementioning

confidence: 99%

“…MIC determinations of ceftazidime, amoxicillin, penicillin, nisin, and baicalein against the S. pyogenes and S. aureus strains were performed using previously reported methods [8,10,11]. Briefly, in addition to an antibacterial or baicalein, an inoculum of 5 x 10 6 cfu/ml bacterial suspension was added to each tube containing CAMHBHB (for S. pyogenes) or CAMBH (for S. aureus), to result in approximately 5 x 10 5 cfu/ml per tube.…”

Section: Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

“…Checkerboard assays to determine the synergistic activity of baicalein in combination with ceftazidime against all tested S. pyogenes strains were performed following Eumkeb et al [8]. The interaction between the two agents was calculated using the fractional inhibitory concentration index (FICI) [12].…”

Section: Checkerboard Assaymentioning

confidence: 99%

“…Discovery of new combination agents to treat these bacteria, overcome β-lactam failures during S. pyogenes treatment and the resurgence of BLPB infections, and reduce adverse drug effects, is urgently needed. Many flavonoids isolated from plants have shown synergistic antibacterial activity [8].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mode of Action and Synergy of Ceftazidime and Baicalein against <i>Streptococcus pyogenes</i>

Siriwong¹,

Pimchan²,

Naknarong³

et al. 2015

Trop. J. Pharm Res

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“…Viable counts for each absorbance reading were determined in triplicate using an agar plate counting method [8,10].…”

Section: Bacterial Suspension Standard Curvementioning

confidence: 99%

Section: Minimum Inhibitory Concentration (Mic)mentioning

confidence: 99%

Section: Checkerboard Assaymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mode of Action and Synergy of Ceftazidime and Baicalein against <i>Streptococcus pyogenes</i>

Siriwong¹,

Pimchan²,

Naknarong³

et al. 2015

Trop. J. Pharm Res

View full text Add to dashboard Cite

“…Ampicillin when used in combination with other growth inhibitor drugs has been shown to enhance growth inhibition and potentiate the cytotoxic effects [15] . Therefore, we examined effect of ampicillin in combination with P. betel fractions against S. aureus, P. aeruginosa and E. coli in the present study.…”

Section: Inhibition Of Bacterial Growth In Ampicillin Combination Trementioning

confidence: 99%

Anti–microbial principles of selected remedial plants from Southern India

Tirupathi

Suresh

Kumar

et al. 2011

Asian Pacific Journal of Tropical Biomedicine

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Antibacterial activity of flavonoids and their structure–activity relationship: An update review

Farhadi

Khameneh

Iranshahi

et al. 2018

Phytotherapy Research

486

305

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Based on World Health Organization reports, resistance of bacteria to well-known antibiotics is a major global health challenge now and in the future. Different strategies have been proposed to tackle this problem including inhibition of multidrug resistance pumps and biofilm formation in bacteria and development of new antibiotics with novel mechanism of action. Flavonoids are a large class of natural compounds, have been extensively studied for their antibacterial activity, and more than 150 articles have been published on this topic since 2005. Over the past decade, some promising results were obtained with the antibacterial activity of flavonoids. In some cases, flavonoids (especially chalcones) showed up to sixfold stronger antibacterial activities than standard drugs in the market. Some synthetic derivatives of flavonoids also exhibited remarkable antibacterial activities with 20-to 80-fold more potent activity than the standard drug against multidrug-resistant Gram-negative and Gram-positive bacteria (including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). This review summarizes the ever changing information on antibacterial activity of flavonoids since 2005, with a special focus on the structure-activity relationship and mechanisms of actions of this broad class of natural compounds.

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Reversing β-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime

Cited by 105 publications

References 27 publications

Mode of Action and Synergy of Ceftazidime and Baicalein against <i>Streptococcus pyogenes</i>

Mode of Action and Synergy of Ceftazidime and Baicalein against <i>Streptococcus pyogenes</i>

Anti–microbial principles of selected remedial plants from Southern India

Antibacterial activity of flavonoids and their structure–activity relationship: An update review

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