Reversion to sensitivity explains limited transmission of resistance in a hospital pathogen
Kevin C. Tracy,
Jordan McKaig,
Clare Kinnear
et al.
Abstract:Bacterial pathogens that are successful in hospital environments must survive times of intense antibiotic exposure and times of no antibiotic exposure. When these organisms are closely associated with human hosts, they must also transmit from one patient to another for the resistance to spread. The resulting evolutionary dynamics have led to rising levels of resistance in hospitals. Here, we focus on an important but understudied aspect of this dynamic: the loss of resistance when resistant organisms evolve in… Show more
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