Review article: BK virus in systemic lupus erythematosus

Gupta, Nakul; Lawrence, Robert M.; Nguyen, Cuong Q.; Modica, Renee

doi:10.1186/s12969-015-0033-9

Cited by 18 publications

(13 citation statements)

References 74 publications

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“…In experimental animals, BKV infection induces the formation of anti-double stranded DNA antibodies[ 362 ]. This finding has led to the suggestion that BKV is implicated in the pathogenesis of SLE, as noted earlier in this report[ 171 , 172 ]. In a recent report, preemptive reduction of immunosuppression for BK viremia was found to be associated with high incidence of formation of HLA-specific antibodies (dnDSA)[ 420 ].…”

Section: Pathogenesis Of Bkv Infection[ 10 supporting

confidence: 67%

“…However, in a series of patients with vasculitis associated with ANCA, only those who had received a kidney transplant exhibited BK viremia[ 170 ]. Manifestations of BKV infection in patients with systemic lupus erythematosus (SLE) include viruria and viremia, and the presence of decoy cells in the urine of a patient with BK viruria, hemorrhagic cystitis and hemophagocytic syndrome[ 171 , 172 ]. The tendency of experimental animals with BKV infection to form anti-double stranded antibodies (anti-dsDNAs) has led to the hypothesis that BKV infection triggers SLE[ 171 ].…”

Section: Bkv Infections In Other Populationsmentioning

confidence: 99%

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BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

Vigil

Konstantinov

Barry

et al. 2016

WJT

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Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy (BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research.

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Section: Pathogenesis Of Bkv Infection[ 10 supporting

confidence: 67%

Section: Bkv Infections In Other Populationsmentioning

confidence: 99%

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

Vigil

Konstantinov

Barry

et al. 2016

WJT

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“…118,123 Other viruses that have been associated with SLE are listed in Table 1. 13,[112][113][114]124 Of interest, some microbes and viruses were reported to be protective against the development of SLE. This may be related to the 'hygiene hypothesis' and is thought to explain the higher incidence of SLE in developed countries where there is an improvement in hygiene and an absence of certain microbes.…”

Section: Genetic and Environmental Factorsmentioning

confidence: 99%

Preventing the development of SLE: identifying risk factors and proposing pathways for clinical care

Choi

Barber

et al. 2016

Lupus

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Although challenging, developing evidence-based approaches to an early and accurate diagnosis of systemic lupus erythematosus is a key approach to preventing disease and lupus-associated morbidity and mortality. Advances in our understanding of preclinical and incomplete lupus erythematosus have enabled the identification of risk factors that may predict disease and the development of potential strategies aimed at primary prevention. Emerging data support the notion that there is a temporal disease progression from initial asymptomatic autoimmunity (preclinical lupus) through early clinical features of the disease (incomplete lupus erythematosus) to finally becoming fully classifiable systemic lupus erythematosus (complete lupus erythematosus). Here, we review the demographic, clinical, biomarker as well as genetic and environmental features that are reported to increase the risk of disease progression. Based on these risk factors, we propose a clinical care pathway for patients with early disease. We envisage that such a pathway, through early identification of disease, may improve patient outcomes, while reducing health care costs.

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“…Nevertheless, other conditions associated with immunosuppression can result in BKV inflammatory damage, such as human immunodeficiency virus (HIV) infection 3 and systemic lupus erythematosus (SLE). 4…”

Section: Introductionmentioning

confidence: 99%

Systemic BK Virus Infection in a Pediatric Patient With Severe Combined Immunodeficiency

et al. 2020

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Human BK virus (BKV) infection is known to occur mostly during childhood with the establishment of latent infection with no tissue damage or clinical manifestations. However, conditions causing immunosuppression can lead to increased virus replication and tissue damage. Although the tissues most commonly involved are the kidneys, bladder, ureters and, to some extent, brain tissue, there are some reports that suggest that BKV may cause multisystemic infections. In this case, a 12-month-old child was seen to suffer from multiple gastrointestinal infections. This prompted a search for immunodeficiencies, which revealed the presence of severe combined immunodeficiency. The child was eventually hospitalized and continued showing recurrent bouts of gastroenteritis as well as lower respiratory infection. After multiple antibiotic courses, he developed acute kidney injury, a hemophagocytic syndrome, and eventually respiratory failure, which led to his death a year later. Autopsy findings revealed the presence of a disseminated BKV infection involving the kidneys, ureters, leptomeninges, and pancreas. Analysis of the literature failed to show any previous case of BKV pancreatitis. The present case suggests that BKV can damage more tissues than previously reported and may be responsible for systemic infections in immunosuppressed patients.

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Review article: BK virus in systemic lupus erythematosus

Cited by 18 publications

References 74 publications

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

Preventing the development of SLE: identifying risk factors and proposing pathways for clinical care

Systemic BK Virus Infection in a Pediatric Patient With Severe Combined Immunodeficiency

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