Review article: breath analysis in inflammatory bowel diseases

Abstract

Breath analysis in IBD is a promising approach that is not yet ready for routine clinical use, but data from other gastrointestinal diseases suggest the feasibility for use of this technology in clinical practice. Well-designed future trials, incorporating the latest breath detection techniques, need to determine the exact breath metabolome pattern linked to diagnosis and phenotype of IBD.

Luminally expressed gastrointestinal biomarkers

“…Diagnosis by breath analysis is an area of much interest as measurements are non-invasive and potentially near real time, making it ideal for screening or point of care diagnosis. However, this is not trivial as human breath is a complex mixture of gases containing at least 3000 different compounds [142], which includes more than 800 volatile organic compounds (VOCs). Changes in the relative concentration of the VOCs may correlate with pathological or physiological changes [143].…”

La méthode Bayésienne pour aider à évaluer l’efficacité des thérapies personnalisées

“…La maladie de Crohn est souvent associée àune dysbiose spécifique avecappauvrissement de la diversité bactérienne [26][27][28].…”

Letter: volatile metabolomics of exhaled breath or faecal gas?

“…1 Their report underlines the unmet need for cost-effective, reproducible, easy-to-perform and noninvasive tests for the diagnosis, differentiation and riskstratification of inflammatory bowel disease (IBD). We agree volatile organic compounds (VOCs) are promising in this respect.…”