Review Article: Solubility Enhancement by Solid Dispersion

Shinkar, D. M.; Patil, A. N.; Saudagar, R. B.

doi:10.5958/2231-5713.2017.00011.3

Cited by 6 publications

(1 citation statement)

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“…2 Different factors affecting solubility, solubility enhancement techniques, its importance and applications has been reported for poorly water soluble drugs. [3][4][5][6][7] Amorphous solid dispersions can be classified according to the molecular interaction of drug and carriers in solid solutions, solid suspensions or a mixture of both. The use of polymers in the preparation of a true solid solution creates an amorphous product in which the crystalline drug is dissolved.…”

Section: Introductionmentioning

confidence: 99%

Solubility Enhancement of BCS Classified II/IV Drug – Solid Dispersion of Apixaban by Solvent Evaporation

Asati

Salunkhe

Chavan

et al. 2020

IJPI

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Section: Introductionmentioning

confidence: 99%

Solubility Enhancement of BCS Classified II/IV Drug – Solid Dispersion of Apixaban by Solvent Evaporation

Asati

Salunkhe

Chavan

et al. 2020

IJPI

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Study on Increasing Solubility of Isolates: Methods and Enhancement Polymers

Nafis

SRIWIDODO²,

Chaerunisaa³

2022

Int J App Pharm

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Natural ingredients have been a source of medicine since ancient times. Research on the development of natural ingredients as medicinal ingredients has increased. One of these is isolating active substances from herbs in a pure state (isolate). However, some problems hinder the use of isolates as the primary treatment option, one of which is solubility. Most isolates had poor solubility, inhibiting the body's absorption process. This review investigates the method and polymer to increase the solubility of isolates and summarizes the development of drugs from isolates. This review also explains how effectively the method and polymer improve the solubility or dissolution of the isolate. We expect the results to be a reference for research on isolates with poor solubility.

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A Study on Improving Bioavailability of Paclitaxel through different Novel Drug Delivery Approaches

Bose¹,

De²,

Bhattacharya³

et al. 2022

RJPT

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Paclitaxel (PTX) obtained from the bark of Taxus brevifolia (Pacific yew tree) is a well-known potent drug used for treatment of breast, lung and ovarian cancer. PTX is stated to be a novel antimicrotubule agent. PTX acts by assembling the microtubule from tubulin dimmers and stabilizing of microtubules by prevention of polymerization. Thus it affects the cell division of the cancer cells by interrupting the spindle formation. PTX on application in cancer treatment it shows to have low aqueous solubility use of vehicles like Cremophore EL and ethanol, which on application shows hypersensitivity reaction. So to reduce the toxicity due to these vehicles three main dosage forms are seen to be developed for application of PTX in chemotherapy by researchers throughout the world. Namely; Nano-Particle Approaches, Liposomal approach, Solid Dispersion approach. Nanoparticles are utilized for purposes like decreasing toxicity and minimizing adverse effects of drug molecules and enhancing drug release. Liposomes are capable of containing more amount of PTX and are capable of long term stability, toxicity reduction when compared to other dosage form. Solid dispersions are more effective compared to other methods of particle size reduction to improve the drug solubility. So it can be stated that developing dosage forms like these for reduction of toxicity and efficacious application of PTX in chemotherapy is important.

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Review Article: Solubility Enhancement by Solid Dispersion

Cited by 6 publications

References 0 publications

Solubility Enhancement of BCS Classified II/IV Drug – Solid Dispersion of Apixaban by Solvent Evaporation

Solubility Enhancement of BCS Classified II/IV Drug – Solid Dispersion of Apixaban by Solvent Evaporation

Study on Increasing Solubility of Isolates: Methods and Enhancement Polymers

A Study on Improving Bioavailability of Paclitaxel through different Novel Drug Delivery Approaches

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