Review: Bioavailability of trace elements in farm animals: definition and practical considerations for improved assessment of efficacy and safety

Brügger, Daniel; Wagner, Bettina; Windisch, W.; Schenkel, H.; Schulz, Kirsten; Südekum, K.-H.; Berk, Andreas; Pieper, Robert; Kowalczyk, J.; Spolders, Markus

doi:10.1016/j.animal.2022.100598

Cited by 14 publications

(10 citation statements)

References 83 publications

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“…En otras palabras, todo intento de probar la superioridad de un determinado suplemento en comparación con una fuente de referencia debe demostrar que puede promover la misma respuesta fisiológica con cantidades o concentraciones totales más bajas del elemento respectivo en la dieta. Esto significa que la fuente superior de un oligoelemento debe reducir la necesidad del suplemento (Brugger et al, 2022). La biodisponibilidad se refiere a la proporción del mineral que se absorbe y utiliza en el organismo.…”

Section: Biodisponibilidadunclassified

Nutrición animal: Texto de formación universitaria

Huanca¹

2023

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El texto que se pone a consideración del lector, en su edición digital, revisada y corregida, ha sido preparado con fines académicos, para la formación de médicos veterinarios y/o zootecnistas, en el contexto del Altiplano de Puno-Perú; sin embargo, puede servir como referencia para todo lector interesado en la nutrición animal. Incluye seis unidades temáticas: fisiología digestiva de los animales, como uno de los procesos nutricionales clave, seguida de energía (carbohidratos), lípidos, proteínas, minerales y vitaminas, y una unidad temática adicional sobre la evaluación de la composición química y calorimetría de los alimentos.

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Section: Biodisponibilidadunclassified

Nutrición animal: Texto de formación universitaria

Huanca¹

2023

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“…Although current regulations in the European Union require approval of using supplemental trace minerals as feed additive in animal feeds, the bioavailability of trace mineral sources have not been considered [ 33 ]. Bioavailability of a trace mineral source is defined as its ability to adequately support the physiological functions of animal metabolism [ 34 ], which is more accurate than trace mineral digestion, absorption, or retention that are common misrepresentations [ 33 ]. Brugger et al [ 33 ] summarized basic, complementary, and potentially beneficial Zn status measures in farm animals, and they are shown in Table 1 .…”

Section: Factors Affecting Zinc Digestion Absorption Metabolism Reten...mentioning

confidence: 99%

“…Bioavailability of a trace mineral source is defined as its ability to adequately support the physiological functions of animal metabolism [ 34 ], which is more accurate than trace mineral digestion, absorption, or retention that are common misrepresentations [ 33 ]. Brugger et al [ 33 ] summarized basic, complementary, and potentially beneficial Zn status measures in farm animals, and they are shown in Table 1 .…”

Section: Factors Affecting Zinc Digestion Absorption Metabolism Reten...mentioning

confidence: 99%

Too Much of a Good Thing: Rethinking Feed Formulation and Feeding Practices for Zinc in Swine Diets to Achieve One Health and Environmental Sustainability

Shurson

Urriola

Hung³

2022

Animals

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The objectives of this review were to summarize current knowledge of Zn in swine nutrition, environmental concerns, potential contribution to antimicrobial resistance, and explore the use of alternative feeding strategies to reduce Zn excretion in manure while capturing improvements in productivity. Zinc is a required nutrient for pigs but is commonly supplemented at concentrations that greatly exceed estimated requirements. Feeding pharmacological concentrations of Zn from ZnO to pigs for 1 to 2 weeks post-weaning reduces post-weaning diarrhea and improves growth performance. Feeding elevated dietary levels of Zn to sows during the last 30 days of gestation can reduce the incidence of low-birth-weight pigs and pre-weaning mortality. Most of the dietary Zn consumed by pigs is not retained in the body and is subsequently excreted in manure, which led several countries to impose regulations restricting dietary Zn concentrations to reduce environmental impacts. Although restricting Zn supplementation in swine diets is a reasonable approach for reducing environmental pollution, it does not allow capturing health and productivity benefits from strategic use of elevated dietary Zn concentrations. Therefore, we propose feeding strategies that allow strategic use of high dietary concentrations of Zn while also reducing Zn excretion in manure compared with current feeding practices.

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“…One of the major drawbacks of oral intake of micronutrients in cattle is reduced absorption due to interactions with other nutrients at the rumen level (24,25). For instance, Cope et al (26) highlighted that Zn deficiency in high-yielding dairy cows is indicative of certain nutritional situations that could affect Zn absorption.…”

Section: Immune Cells and Activity 1 Introductionmentioning

confidence: 99%

“…Santschi et al (27) demonstrated that extensive loss of supplemented vitamin B occurs in the rumen of the cows before reaching the small intestine, which reduces the utilization of orally supplemented vitamins. Roughage with higher molybdenum (Mo) and sulphur (S) content leads to the formation of thiomolybdates in the rumen, which bind copper (Cu) ions and form a highly insoluble complex, greatly reducing Cu absorption and utilization (25,28). In addition, excessive Fe feeding leads to Mn and Cu deficiency in ruminants (24,29).…”

Section: Immune Cells and Activity 1 Introductionmentioning

confidence: 99%

Repeated injection of multivitamins and multiminerals during the transition period enhances immune response by suppressing inflammation and oxidative stress in cows and their calves

Somagond

Alhussien²,

Dang³

2023

Front. Immunol.

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Periparturient dairy cows undergo major physiological and metabolic changes as well as immunosuppression, associated with decrease in plasma concentrations of various minerals and vitamins. The present study was conducted to investigate effects of repeated injections of vitamins and minerals on oxidative stress, innate and adaptive immune response in periparturient dairy cows and their offspring. Experiment was carried out on 24 peripartum Karan-Fries cows, randomly divided into four groups (n=6): control, Multi-mineral (MM), Multi-vitamin (MV) and Multi-minerals and Multi-vitamin (MMMV). Five ml of MM (Zinc 40 mg/ml, Manganese 10 mg/ml, Copper 15 mg/ml, Selenium 5 mg/ml) and five ml of MV (Vitamin E 5 mg/ml, Vitamin A 1000 IU/ml, B-Complex 5 mg/ml, and Vitamin D3 500 IU/ml) were injected intramuscularly (IM) to the MM and MV groups. MMMV group cows were injected with both. In all treatment groups, injections and blood sampling were carried out on 30th, 15th, 7th days before and after expected date of parturition and at calving. In calves, blood was collected at calving and on 1, 2, 3, 4, 7, 8, 15, 30 and 45 days post-calving. Colostrum/milk were collected at calving and at days 2, 4, and 8 post-calving. A lower percentage of total neutrophils and immature neutrophils, higher percentage of lymphocytes together with increased phagocytic activity of neutrophils and proliferative capacity of lymphocytes found in blood of MMMV cows/calves. Lower relative mRNA expression of TLRs and CXCRs and higher mRNA expression of GR-α, CD62L, CD11b, CD25 and CD44 found in blood neutrophils of MMMV groups. Total antioxidant capacity was higher, activity of antioxidant enzymes (SOD and CAT), TBARS levels were lower in the blood plasma of treated cows/calves. In both cows/calves, plasma pro-inflammatory cytokines (IL-1α, IL-1β, IL-6, IL-8, IL-17A, IFN-γ and TNF-α) increased, whereas anti-inflammatory cytokines (IL-4 and IL-10) decreased in MMMV groups. Total immunoglobulins increased in colostrum/milk of MMMV injected cows and plasma of their calves. Results indicate that repeated injections of multivitamins and multiminerals to peripartum dairy cows could be a major strategy to improve immune response and decrease in inflammation and oxidative stress in transition dairy cows and their calves.

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Review: Bioavailability of trace elements in farm animals: definition and practical considerations for improved assessment of efficacy and safety

Cited by 14 publications

References 83 publications

Nutrición animal: Texto de formación universitaria

Nutrición animal: Texto de formación universitaria

Too Much of a Good Thing: Rethinking Feed Formulation and Feeding Practices for Zinc in Swine Diets to Achieve One Health and Environmental Sustainability

Repeated injection of multivitamins and multiminerals during the transition period enhances immune response by suppressing inflammation and oxidative stress in cows and their calves

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