Review: Colon Capsule Endoscopy in Inflammatory Bowel Disease

Halder, Writaja; Laskaratos, Faidon-Marios; El-Mileik, Hanan; Coda, Sergio; Fox, Stevan; Banerjee, Saswata; Epstein, Owen

doi:10.3390/diagnostics12010149

Cited by 10 publications

(4 citation statements)

References 53 publications

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“…Capsule endoscopy, which was authorized by the Food and Drug Administration (FDA) in 2001, enables a convenient and secure inspection of the gastrointestinal system. This technology has greatly revolutionized the treatment of small bowel disorders [ 44 ]. Studies have demonstrated that it can effectively display significant anatomical features of the esophagus and the entire stomach [ 39 ].…”

Section: Reviewmentioning

confidence: 99%

Emerging Technologies in Endoscopy for Gastrointestinal Neoplasms: A Comprehensive Overview

Nijjar,

Aulakh,

Singh

et al. 2024

Cureus

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Gastrointestinal neoplasms are a growing global health concern, requiring prompt identification and treatment. Endoscopic procedures have revolutionized the detection and treatment of gastrointestinal tumors by providing accurate, minimally invasive methods. Early-stage malignancies can be treated with endoscopic excision, leading to improved outcomes and increased survival rates. Precancerous lesions, like adenomatous polyps, can be prevented by removing them, reducing cancer occurrence and death rates. Advanced techniques like chromoendoscopy, narrow-band imaging, and confocal laser endomicroscopy improve the ability to see the mucosa surface and diagnose conditions. Artificial Intelligence (AI) applications in endoscopy can enhance diagnostic accuracy and predict histology outcomes. However, challenges remain in accurately defining lesions and ensuring precise diagnosis and treatment selection. Molecular imaging approaches and therapeutic modalities like photodynamic therapy and endoscopic ultrasonography-guided therapies hold potential but require further study and clinical confirmation. This study examines the future prospects and obstacles in endoscopic procedures for the timely identification and treatment of gastrointestinal cancers. The focus is on developing technology, limits, and prospective effects on clinical practice.

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Section: Reviewmentioning

confidence: 99%

Emerging Technologies in Endoscopy for Gastrointestinal Neoplasms: A Comprehensive Overview

Nijjar,

Aulakh,

Singh

et al. 2024

Cureus

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“…15 VCE has garnered attention as a minimally invasive diagnostic in various settings, particularly for evaluating and monitoring CD. [16][17][18][19][20] However, VCE's health-economic implications in CD surveillance remain understudied, 21 without evidence specific to Italian healthcare. We had previously shown VCE as a cost-effective alternative in the mid-to-long term in the United Kingdom and United States, with higher initial costs recouped through improved management over time, using a patient-level discrete-event simulation model.…”

Section: Introductionmentioning

confidence: 99%

Validation of a Model Estimating the Budget Impact of Video Capsule Endoscopy for Surveillance of Crohn’s Disease in an Italian Center

Saunders,

Calabrese,

Gelli

et al. 2024

Journal of Health Economics and Outcomes Research

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Background: Crohn’s disease is a chronic ailment affecting the gastrointestinal tract. Mucosal healing, a marker of reduced disease activity, is currently assessed in the colonic sections using ileocolonoscopy and magnetic resonance enteroscopy. Video capsule endoscopy (VCE) offers visualization of the entire GI mucosae. Objective: To validate a Crohn’s disease model estimating the budget impact of VCE compared with the standard of care (SOC) in Italy. Methods: A patient-level, discrete-event simulation was developed to estimate the budget impact of VCE compared with SOC for Crohn’s disease surveillance over 5 years in the Italian setting. Input data were sourced from a physician-initiated study from Sant’Orsola-Malpighi Hospital in Bologna, Italy, and the literature. The care pathway followed hospital clinical practice. Comparators were the current SOC (ileocolonoscopy, with or without magnetic resonance enteroscopy) and VCE. Sensitivity analysis was performed using 500-patient bootstraps. A comparative analysis regarding clinical outcomes (biologics use, surgical interventions, symptom remission) was performed to explore the validity of the model compared with real-world data. Cumulative event incidences were compared annually and semi-annually. Bayesian statistical analysis further validated the model. Results: Implementing VCE yielded an estimated €67 savings per patient per year, with savings in over 55% of patients, compared with SOC. While annual costs are higher up to the second year, VCE becomes cost saving from the third year onward. The real-world validation analysis proved a good agreement between the model and real-world patient records. The highest agreement was found for biologics, where Bayesian analysis estimated an 80.4% probability (95% CI: 72.2%-87.5%) that a decision maker would accept the result as an actual reflection of real-world data. Even where trend data diverged (eg, for surgery [43.1% likelihood of acceptance, 95% CI: 33.7%-52.8%]), the cumulative surgery count over 5 years was within the margin of error of the real-world data. Conclusions: Implementing VCE in the surveillance of patients with Crohn’s disease and small bowel involvement may be cost saving in Italy. The congruence between model predictions and real-world patient records supports using this discrete-event simulation to inform healthcare decisions.

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“…As it is non-invasive and a comparatively more comfortable procedure than colonoscopy, it is also preferred by many patients for investigation of the colon 1 . The limited capacity for patient examinations during the COVID 19 pandemic 2 further propelled its use as it is less resource and time consuming. WCE has been established as a promising alternative for the diagnosis and monitoring of various diseases, including lesions such as polyps, tumors 3 , 4 , Ulcerative Colitis (UC) 5 , Chron’s disease 6 as well as other markers related to inflammatory bowel diseases such as inflammatory grading (occurrence of bleeding, ulcers, erosions), mucosal healing (edema, changes in mucosal vascularity), etc.…”

Section: Introductionmentioning

confidence: 99%

Evaluating clinical diversity and plausibility of synthetic capsule endoscopic images

Vats¹,

Pedersen²,

Mohammed

et al. 2023

Sci Rep

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Wireless Capsule Endoscopy (WCE) is being increasingly used as an alternative imaging modality for complete and non-invasive screening of the gastrointestinal tract. Although this is advantageous in reducing unnecessary hospital admissions, it also demands that a WCE diagnostic protocol be in place so larger populations can be effectively screened. This calls for training and education protocols attuned specifically to this modality. Like training in other modalities such as traditional endoscopy, CT, MRI, etc., a WCE training protocol would require an atlas comprising of a large corpora of images that show vivid descriptions of pathologies, ideally observed over a period of time. Since such comprehensive atlases are presently lacking in WCE, in this work, we propose a deep learning method for utilizing already available studies across different institutions for the creation of a realistic WCE atlas using StyleGAN. We identify clinically relevant attributes in WCE such that synthetic images can be generated with selected attributes on cue. Beyond this, we also simulate several disease progression scenarios. The generated images are evaluated for realism and plausibility through three subjective online experiments with the participation of eight gastroenterology experts from three geographical locations and a variety of years of experience. The results from the experiments indicate that the images are highly realistic and the disease scenarios plausible. The images comprising the atlas are available publicly for use in training applications as well as supplementing real datasets for deep learning.

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Review: Colon Capsule Endoscopy in Inflammatory Bowel Disease

Cited by 10 publications

References 53 publications

Emerging Technologies in Endoscopy for Gastrointestinal Neoplasms: A Comprehensive Overview

Emerging Technologies in Endoscopy for Gastrointestinal Neoplasms: A Comprehensive Overview

Validation of a Model Estimating the Budget Impact of Video Capsule Endoscopy for Surveillance of Crohn’s Disease in an Italian Center

Evaluating clinical diversity and plausibility of synthetic capsule endoscopic images

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