Review for Analytical Methods for the Determination of Mefenamic Acid

Abstract

Mefenamic acid (MFA) is a non-steroidal anti-inflammatory drug that belongs to the anthranilic acid derivative family. It is used to relieve mild to moderate pain. The present review article includes a compilation of articles on the various properties along with an extensive literature survey on the reported analytical methods of MFA. Using a comprehensive computer assisted literature review; this article discusses the analytical methodologies for quantifying MFA both in active pharmaceutical ingredient and pharmaceutical dosage forms. This is the first review article in this series with focus on the analytical profile of MFA. Although, several methods like High Performance Liquid Chromatography (HPLC), Thin Layer Chromatography (TLC), spectrophotometry, fluorimetry, turbidimetry, Atomic Absorption Spectroscopy (AAS), Mass Spectroscopy (MS) and electro analytical methods were reported in the literature, HPLC stands out first for the quantification of MFA.

Fabrication of an Electrocatalyst Based on Rare Earth Manganites Incorporated with Carbon Nanofiber Hybrids: An Efficient Electrochemical Biosensor for the Detection of Anti-Inflammatory Drug Mefenamic Acid

“…The pathophysiological functions of MA are implemented by its ability to inhibit the biosynthesis of prostaglandin involved in pathogen diseases. MA is used to treat rheumatoid arthritis, osteoarthritis, autoimmune hemolytic anemia, sports injuries, gastrointestinal disorders, primary dysmenorrhea muscle pain, back pain, and dental pain [2][3][4][5]. As MA works on cyclooxygenase (COX) pathways and suppresses prostaglandin, the sensations of pain are momentarily lessened.…”

Método de inyección de flujo sensible a base de neocuproina para la determinación de ácido mefenámico en soluciones acuosas y formulaciones farmacéuticas

“…Because of its selectivity for copper(I) and potent visual absorbance of the Cu(DMP) 2+ adduct, 2,9-dimethyl-1,10-phenanthroline (NC) is typically the reagent chosen for the colorimetric measurement of copper(I) (14) Water-insoluble mefenamic acid is somewhat soluble in (chloroform) and (ethers), faintly soluble in ethanol (4.6 mg/mL) and water (1:9), and more soluble in dimethylformamidee (38.5 mg/mL) (4) Mefenamic acid reduces inflammation and pain by inhibiting COX and prostaglandin synthesis since it provides cerebral and peripheral analgesia. Its nonselective COX inhibitors inhibit both COX-1 and COX-2 enzymes (5) Mefenamic Acid (MFA) operates in the same way as other nonsteroidal anti-inflammatory medicines by which blocking the enzymatic prostaglandin synthase (6) There are several known and reported analytical methods for measuring MEF acid in biological and pharmacological products (7) Spectrophotometry (8) Gas Chromatography (9) Extraction method of Micro-electrodriven Membranes in 2 Phases (10) capillary electrophoresis with two channels (11) RP-HPLC (12) Fluorometric method (13) Hyphenated Tech-niques (14) Electrospray Ionization Mass Spectrometry (15) Turbidity Measurement (16) flow injection method (17) MEF is determined by different flow injection technique, it has been estimated in pharmaceuticals by flow-injection (18) and estimation of Mefenamic Acid in Aqueous Solutions Using Reverse -Continuous Flow Injection Analysis (6) determination of MEF in pharmaceuticals formulation by flow-injection Fluorometry (21). However, in recent years there has been a growing interest in the use of Neocuproine (2,9-dimethyl-1,10-phenanthroline) as a complexing agent in analytical chemistry.…”