Review: Medication Delivery in the Short‐Bowel Syndrome

Abstract

Technologic advances such as total parenteral nutrition have prolonged the lives of individuals with short-bowel syndrome who previously would not have survived. However, the day-to-day management of these patients presents a significant challenge to those who take care of them. Providing medications on either an acute or chronic basis without the use of their central catheters is a difficult clinical problem. This article reviews the approach and methods of treating short-bowel patients on the basis of their individual circumstances and physiology.

Short‐Bowel Syndrome: Epidemiology, Hospitalization Trends, In‐Hospital Mortality, and Healthcare Utilization

“…[70][71][72] The spectrum of care provided to these patients has further expanded and now encompasses many other aspects of their care, including quality of life and psychosocial support via multidisciplinary approaches. 54,63,[73][74][75][76] Several professional organizations from North America and Europe, such as the American Society for Parenteral and Enteral Nutrition and the European Society for Clinical Nutrition and Metabolism, and nonprofit organizations, such as the Oley Foundation, Crohn's and Colitis Foundation, Short Bowel Syndrome Foundation, and National Organization of Rare Diseases, have also dedicated a significant amount of their resources to improve the outcomes in patients with SBS. 77,78 Formations of online communities of medical professionals specializing in IF management have also streamlined various aspects of the medical and surgical care of these patients by bringing together several experts of the field on 1 platform.…”

“…Patients are closely monitored for some of these major complications, which include catheter‐related infection and IF‐associated liver disease (IFALD), and measures are taken to limit the consequences of them 70–72 . The spectrum of care provided to these patients has further expanded and now encompasses many other aspects of their care, including quality of life and psychosocial support via multidisciplinary approaches 54,63,73–76 . Several professional organizations from North America and Europe, such as the American Society for Parenteral and Enteral Nutrition and the European Society for Clinical Nutrition and Metabolism, and nonprofit organizations, such as the Oley Foundation, Crohn's and Colitis Foundation, Short Bowel Syndrome Foundation, and National Organization of Rare Diseases, have also dedicated a significant amount of their resources to improve the outcomes in patients with SBS 77,78 .…”

The Impact of Intestinal Failure on Oral Drug Absorption: A Review

“…Some efforts have been made in the literature to make some suggestions regarding alternative routes of administration in short bowel syndrome. 3 However, this strategy of total avoidance of the oral route is not always practical.…”